Hmdb loader

HMDBP00525 (Cholinesterase) Metabolite Associations

Displaying metabolite protein links 1 - 25 of 58 in total
HMDB ID Name CAS NumberStructureFormula Average Mass
Monoisotopic Mass 		References
HMDB0000039Butyric acid107-92-6ThumbC4H8O288.1051
88.0524295		Not Available
HMDB0000097Choline62-49-7ThumbC5H14NO104.1708
104.107539075		Not Available
HMDB0000169D-Mannose3458-28-4ThumbC6H12O6180.1559
180.063388116
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
HMDB0000220Palmitic acid57-10-3ThumbC16H32O2256.4241
256.240230268		Not Available
HMDB0000806Myristic acid544-63-8ThumbC14H28O2228.3709
228.20893014		Not Available
HMDB0000826Pentadecanoic acid1002-84-2ThumbC15H30O2242.3975
242.224580204		Not Available
HMDB0000827Stearic acid57-11-4ThumbC18H36O2284.4772
284.271530396		Not Available
HMDB0000895Acetylcholine51-84-3ThumbC7H16NO2146.2074
146.118103761		Not Available
HMDB0000910Tridecanoic acid638-53-9ThumbC13H26O2214.3443
214.193280076		Not Available
HMDB0001043Arachidonic acid506-32-1ThumbC20H32O2304.4669
304.240230268		Not Available
HMDB0001897Substance P33507-63-0ThumbC63H98N18O13S1347.63
1346.728146002
  1. Lockridge O: Substance P hydrolysis by human serum cholinesterase. J Neurochem. 1982 Jul;39(1):106-10. [PubMed:6177830 ]
HMDB0002111Water7732-18-5ThumbH2O18.0153
18.010564686		Not Available
HMDB0002212Arachidic acid506-30-9ThumbC20H40O2312.5304
312.302830524		Not Available
HMDB0002259Heptadecanoic acid506-12-7ThumbC17H34O2270.4507
270.255880332		Not Available
HMDB0005041Donepezil120014-06-4ThumbC24H29NO3379.492
379.214743799		Not Available
HMDB0006497Heptadecanoyl CoA3546-17-6ThumbC38H68N7O17P3S1019.97
1019.360524011		Not Available
HMDB0013930R-95913ThumbC18H18FNO2S331.404
331.10422772
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
HMDB0014324Ramipril87333-19-5ThumbC23H32N2O5416.5106
416.231122144
  1. Shah GB, Sharma S, Mehta AA, Goyal RK: Oculohypotensive effect of angiotensin-converting enzyme inhibitors in acute and chronic models of glaucoma. J Cardiovasc Pharmacol. 2000 Aug;36(2):169-75. [PubMed:10942157 ]
HMDB0014329Pentagastrin5534-95-2ThumbC37H49N7O9S767.891
767.331246891
  1. Chernysheva SV, Iaremko EE: [Cholinergic and hormonal correlations in the regulation of the secretory function of the small intestine]. Fiziol Zh SSSR Im I M Sechenova. 1983 Jun;69(6):827-31. [PubMed:6873393 ]
HMDB0014347Succinylcholine306-40-1ThumbC14H30N2O4290.399
290.220557458
  1. Ostergaard D, Engbaek J, Viby-Mogensen J: Adverse reactions and interactions of the neuromuscular blocking drugs. Med Toxicol Adverse Drug Exp. 1989 Sep-Oct;4(5):351-68. [PubMed:2682131 ]
HMDB0014502Mefloquine53230-10-7ThumbC17H16F6N2O378.3122
378.116682374
  1. Lim LY, Go ML: The anticholinesterase activity of mefloquine. Clin Exp Pharmacol Physiol. 1985 Sep-Oct;12(5):527-31. [PubMed:3878759 ]
  2. Zhou C, Xiao C, McArdle JJ, Ye JH: Mefloquine enhances nigral gamma-aminobutyric acid release via inhibition of cholinesterase. J Pharmacol Exp Ther. 2006 Jun;317(3):1155-60. Epub 2006 Feb 24. [PubMed:16501066 ]
  3. McArdle JJ, Sellin LC, Coakley KM, Potian JG, Quinones-Lopez MC, Rosenfeld CA, Sultatos LG, Hognason K: Mefloquine inhibits cholinesterases at the mouse neuromuscular junction. Neuropharmacology. 2005 Dec;49(8):1132-9. Epub 2005 Aug 2. [PubMed:16081111 ]
HMDB0014526Tacrine321-64-2ThumbC13H14N2198.2637
198.115698458
  1. Wang H, Tang XC: Anticholinesterase effects of huperzine A, E2020, and tacrine in rats. Zhongguo Yao Li Xue Bao. 1998 Jan;19(1):27-30. [PubMed:10375753 ]
  2. Krustev AD, Argirova MD, Getova DP, Turiiski VI, Prissadova NA: Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles. Can J Physiol Pharmacol. 2006 Nov;84(11):1133-8. [PubMed:17218977 ]
  3. Marco JL, Carreiras MC: Recent developments in the synthesis of acetylcholinesterase inhibitors. Mini Rev Med Chem. 2003 Sep;3(6):518-24. [PubMed:12871155 ]
  4. Ahmed M, Rocha JB, Correa M, Mazzanti CM, Zanin RF, Morsch AL, Morsch VM, Schetinger MR: Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25;162(2):165-71. Epub 2006 Jun 17. [PubMed:16860785 ]
HMDB0014535Sulpiride15676-16-1ThumbC15H23N3O4S341.426
341.140926929
  1. Vacca C, Maione S, Tozzi A, Marmo E: Benzamides and cholinesterases. Res Commun Chem Pathol Pharmacol. 1987 Feb;55(2):193-201. [PubMed:3823608 ]
  2. Dross K: [The relevance of anticholinesterase properties to toxicity and neuromuscular effects of sulpiride (author's transl)]. Arzneimittelforschung. 1977 Feb;27(2):404-6. [PubMed:577162 ]
HMDB0014536Ethopropazine1094-08-2ThumbC19H24N2S312.472
312.166019468
  1. Reiner E, Bosak A, Simeon-Rudolf V: Activity of cholinesterases in human whole blood measured with acetylthiocholine as substrate and ethopropazine as selective inhibitor of plasma butyrylcholinesterase. Arh Hig Rada Toksikol. 2004 Apr;55(1):1-4. [PubMed:15137175 ]
  2. Sinko G, Kovarik Z, Reiner E, Simeon-Rudolf V, Stojan J: Mechanism of stereoselective interaction between butyrylcholinesterase and ethopropazine enantiomers. Biochimie. 2011 Oct;93(10):1797-807. doi: 10.1016/j.biochi.2011.06.023. Epub 2011 Jun 29. [PubMed:21740955 ]
HMDB0014592Dipivefrin52365-63-6ThumbC19H29NO5351.4373
351.204573043
  1. Nakamura M, Shirasawa E, Hikida M: Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride. Ophthalmic Res. 1993;25(1):46-51. [PubMed:8446367 ]
Displaying metabolite protein links 1 - 25 of 58 in total