Hmdb loader
Identification
HMDB Protein ID HMDBP08240
Secondary Accession Numbers
  • 13952
Name High affinity copper uptake protein 1
Synonyms
  1. Copper transporter 1
  2. Solute carrier family 31 member 1
  3. hCTR1
Gene Name SLC31A1
Protein Type Transporter
Biological Properties
General Function Involved in copper ion transmembrane transporter activity
Specific Function Involved in high-affinity copper uptake
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
di-, tri-valent inorganic cation transmembrane transporter activity
copper ion transmembrane transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
transporter activity
Process
copper ion transport
establishment of localization
transport
ion transport
cation transport
metal ion transport
transition metal ion transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Probable)
Gene Properties
Chromosome Location Chromosome:9
Locus 9q31-q32
SNPs SLC31A1
Gene Sequence
>573 bp
ATGGATCATTCCCACCATATGGGGATGAGCTATATGGACTCCAACAGTACCATGCAACCT
TCTCACCATCACCCAACCACTTCAGCCTCACACTCCCATGGTGGAGGAGACAGCAGCATG
ATGATGATGCCTATGACCTTCTACTTTGGCTTTAAGAATGTGGAACTACTGTTTTCCGGT
TTGGTGATCAATACAGCTGGAGAAATGGCTGGAGCTTTTGTGGCAGTGTTTTTACTAGCA
ATGTTCTATGAAGGACTCAAGATAGCCCGAGAGAGCCTGCTGCGTAAGTCACAAGTCAGC
ATTCGCTACAATTCCATGCCTGTCCCAGGACCAAATGGAACCATCCTTATGGAGACACAC
AAAACTGTTGGGCAACAGATGCTGAGCTTTCCTCACCTCCTGCAAACAGTGCTGCACATC
ATCCAGGTGGTCATAAGCTACTTCCTCATGCTCATCTTCATGACCTACAACGGGTACCTC
TGCATTGCAGTAGCAGCAGGGGCCGGTACAGGATACTTCCTCTTCAGCTGGAAGAAGGCA
GTGGTAGTGGATATCACAGAGCATTGCCATTGA
Protein Properties
Number of Residues 190
Molecular Weight 21090.5
Theoretical pI 7.47
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 62-82
  • 133-153
  • 157-177
Protein Sequence
>High affinity copper uptake protein 1
MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSG
LVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETH
KTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKA
VVVDITEHCH
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O15431
UniProtKB/Swiss-Prot Entry Name COPT1_HUMAN
PDB IDs Not Available
GenBank Gene ID U83460
GeneCard ID SLC31A1
GenAtlas ID SLC31A1
HGNC ID HGNC:11016
References
General References
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  5. Zhou B, Gitschier J: hCTR1: a human gene for copper uptake identified by complementation in yeast. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7481-6. [PubMed:9207117 ]
  6. Maryon EB, Molloy SA, Kaplan JH: O-linked glycosylation at threonine 27 protects the copper transporter hCTR1 from proteolytic cleavage in mammalian cells. J Biol Chem. 2007 Jul 13;282(28):20376-87. Epub 2007 May 24. [PubMed:17525160 ]
  7. Aller SG, Unger VM: Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3627-32. Epub 2006 Feb 24. [PubMed:16501047 ]