HMDB0014608 | Ketorolac | 66635-83-4 |  | C15H13NO3 | 255.2686 255.089543287 | - Bosch-Marce M, Claria J, Titos E, Masferrer JL, Altuna R, Poo JL, Jimenez W, Arroyo V, Rivera F, Rodes J: Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites. Gastroenterology. 1999 May;116(5):1167-75. [PubMed:10220509 ]
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HMDB0014643 | Tolmetin | 26171-23-3 |  | C15H15NO3 | 257.2845 257.105193351 | - Capasso A, Sorrentino L: Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum. Eur J Pharmacol. 1997 Jul 9;330(2-3):199-204. [PubMed:9253954 ]
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HMDB0015471 | Salsalate | 552-94-3 |  | C14H10O5 | 258.2262 258.05282343 | - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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HMDB0015008 | Suprofen | 40828-46-4 |  | C14H12O3S | 260.308 260.05071494 | - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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HMDB0015538 | Tiaprofenic acid | 33005-95-7 |  | C14H12O3S | 260.308 260.05071494 | - Martic M, Tatic I, Markovic S, Kujundzic N, Kostrun S: Synthesis, biological activity and molecular modeling studies of novel COX-1 inhibitors. Eur J Med Chem. 2004 Feb;39(2):141-51. [PubMed:14987823 ]
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HMDB0014680 | Nortriptyline | 72-69-5 |  | C19H21N | 263.3767 263.167399677 | - Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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HMDB0014959 | Carprofen | 53716-49-7 |  | C15H12ClNO2 | 273.714 273.05565634 | - Beretta C, Garavaglia G, Cavalli M: COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6. [PubMed:15939622 ]
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HMDB0013870 | cis,trans-5'-Hydroxythalidomide | |  | C13H10N2O5 | 274.2289 274.05897144 | - Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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HMDB0015573 | Niflumic Acid | 4394-00-7 |  | C13H9F3N2O2 | 282.218 282.061612157 | - Talbot S, Lin JC, Lahjouji K, Roy JP, Senecal J, Morin A, Couture R: Cigarette smoke-induced kinin B1 receptor promotes NADPH oxidase activity in cultured human alveolar epithelial cells. Peptides. 2011 Jul;32(7):1447-56. doi: 10.1016/j.peptides.2011.05.005. Epub 2011 May 11. [PubMed:21600945 ]
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HMDB0014995 | Terbinafine | 91161-71-6 |  | C21H25N | 291.4299 291.198699805 | - Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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HMDB0014024 | 2-Hydroxychlorpropamide | 36892-36-1 |  | C10H13ClN2O4S | 292.739 292.028455311 | - Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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HMDB0015126 | Oxaprozin | 21256-18-8 |  | C18H15NO3 | 293.3166 293.105193351 | - Kawai S: Cyclooxygenase selectivity and the risk of gastro-intestinal complications of various non-steroidal anti-inflammatory drugs: a clinical consideration. Inflamm Res. 1998 Oct;47 Suppl 2:S102-6. [PubMed:9831331 ]
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HMDB0015403 | Lumiracoxib | 220991-20-8 |  | C15H13ClFNO2 | 293.721 293.061884577 | - Capone ML, Tacconelli S, Sciulli MG, Patrignani P: Clinical pharmacology of selective COX-2 inhibitors. Int J Immunopathol Pharmacol. 2003 May-Aug;16(2 Suppl):49-58. [PubMed:14552704 ]
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HMDB0015074 | Meclofenamic acid | 644-62-2 |  | C14H11Cl2NO2 | 296.149 295.016684015 | - Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL: Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res. 2004 Jun;65(6):810-8. [PubMed:15198222 ]
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HMDB0001999 | Eicosapentaenoic acid | 10417-94-4 |  | C20H30O2 | 302.451 302.224580204 | - Das UN: Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids? J Assoc Physicians India. 2005 Jul;53:623-7. [PubMed:16190133 ]
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HMDB0001043 | Arachidonic acid | 506-32-1 |  | C20H32O2 | 304.4669 304.240230268 | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
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HMDB0014950 | Phenylbutazone | 50-33-9 |  | C19H20N2O2 | 308.3743 308.152477894 | - Zitova A, Hynes J, Kollar J, Borisov SM, Klimant I, Papkovsky DB: Analysis of activity and inhibition of oxygen-dependent enzymes by optical respirometry on the LightCycler system. Anal Biochem. 2010 Feb 15;397(2):144-51. doi: 10.1016/j.ab.2009.10.029. Epub 2009 Oct 20. [PubMed:19849999 ]
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HMDB0013974 | 4'-Hydroxydiclofenac | 64118-84-9 |  | C14H11Cl2NO3 | 312.148 311.011598637 | - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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HMDB0014613 | Tetrahydrocannabinol | 1972-08-3 |  | C21H30O2 | 314.4617 314.224580204 | - Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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HMDB0014869 | Nateglinide | 105816-04-4 |  | C19H27NO3 | 317.4226 317.199093735 | - Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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HMDB0015098 | Bromfenac | 91714-94-2 |  | C15H12BrNO3 | 334.165 333.000055902 | - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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HMDB0014096 | 5'-Hydroxypiroxicam | 77459-78-0 |  | C15H13N3O5S | 347.346 347.057591231 | - Fackovcova D, Kristova V, Kriska M: Renal damage induced by the treatment with non-opioid analgesics--theoretical assumption or clinical significance. Bratisl Lek Listy. 2000;101(8):417-22. [PubMed:11153163 ]
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HMDB0014359 | Torasemide | 56211-40-6 |  | C16H20N4O3S | 348.42 348.125611216 | - Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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HMDB0014720 | Voriconazole | 137234-62-9 |  | C16H14F3N5O | 349.3105 349.11504471 | - Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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HMDB0014952 | Meloxicam | 71125-38-7 |  | C14H13N3O4S2 | 351.401 351.034747299 | - Blanco FJ, Guitian R, Moreno J, de Toro FJ, Galdo F: Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73. [PubMed:10381057 ]
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