| HMDB0000027 | Tetrahydrobiopterin | 62989-33-7 |  | C9H15N5O3 | 241.2471
241.117489371 | - Madsen JT, Jansen P, Hesslinger C, Meyer M, Zimmer J, Gramsbergen JB: Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures. J Neurochem. 2003 Apr;85(1):214-23. [PubMed:12641743 ]
|
| HMDB0000038 | Dihydrobiopterin | 6779-87-9 |  | C9H13N5O3 | 239.2312
239.101839307 | - Goodwill KE, Sabatier C, Stevens RC: Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site. Biochemistry. 1998 Sep 29;37(39):13437-45. [PubMed:9753429 ]
|
| HMDB0000158 | L-Tyrosine | 60-18-4 |  | C9H11NO3 | 181.1885
181.073893223 | - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
- Olsovska J, Novotna J, Flieger M, Spizek J: Assay of tyrosine hydroxylase based on high-performance liquid chromatography separation and quantification of L-dopa and L-tyrosine. Biomed Chromatogr. 2007 Dec;21(12):1252-8. [PubMed:17604359 ]
- Bodnar I, Hechtl D, Szekacs D, Olah M, Nagy GM: Effect of local (intracerebral and intracerebroventricular) administration of tyrosine hydroxylase inhibitor on the neuroendocrine dopaminergic neurons and prolactin release. Ideggyogy Sz. 2007 Mar 30;60(3-4):177-81. [PubMed:17451064 ]
- Rostrup M, Fossbakk A, Hauge A, Kleppe R, Gnaiger E, Haavik J: Oxygen dependence of tyrosine hydroxylase. Amino Acids. 2008 Apr;34(3):455-64. Epub 2007 May 23. [PubMed:17520326 ]
- Richards AB, Scheel TA, Wang K, Henkemeyer M, Kromer LF: EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity. Eur J Neurosci. 2007 May;25(9):2619-28. [PubMed:17561836 ]
- Ugriumov MV: [Brain neurons partly expressing monoaminergic phenotype: distribution, development, and functional significance]. Usp Fiziol Nauk. 2007 Apr-Jun;38(2):3-25. [PubMed:17578016 ]
|
| HMDB0000159 | Phenylalanine | 63-91-2 |  | C9H11NO2 | 165.1891
165.078978601 | - Fusetti F, Erlandsen H, Flatmark T, Stevens RC: Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria. J Biol Chem. 1998 Jul 3;273(27):16962-7. [PubMed:9642259 ]
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
- Fukami MH, Haavik J, Flatmark T: Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells. Biochem J. 1990 Jun 1;268(2):525-8. [PubMed:1973034 ]
- Ogawa S, Ichinose H: Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5. Epub 2006 Apr 11. [PubMed:16581181 ]
- Schallreuter KU, Kothari S, Hasse S, Kauser S, Lindsey NJ, Gibbons NC, Hibberts N, Wood JM: In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes. Biochem Biophys Res Commun. 2003 Feb 7;301(2):610-6. [PubMed:12565907 ]
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|
| HMDB0000181 | DOPA | 59-92-7 |  | C9H11NO4 | 197.1879
197.068807845 | Not Available |
| HMDB0000609 | DL-Dopa | 63-84-3 |  | C9H11NO4 | 197.1879
197.068807845 | Not Available |
| HMDB0000692 | Fe2+ | 15438-31-0 |  | Fe | 55.845
55.934942133 | Not Available |
| HMDB0001377 | Oxygen | 7782-44-7 |  | O2 | 31.9988
31.989829244 | Not Available |
| HMDB0002111 | Water | 7732-18-5 |  | H2O | 18.0153
18.010564686 | Not Available |
| HMDB0002215 | 4a-Carbinolamine tetrahydrobiopterin | 79647-29-3 |  | C9H13N5O3 | 239.2312
239.101839307 | Not Available |
| HMDB0002281 | 4a-Hydroxytetrahydrobiopterin | 1379003-93-6 |  | C9H15N5O4 | 257.25
257.112403983 | Not Available |
| HMDB0014903 | Metyrosine | 672-87-7 |  | C10H13NO3 | 195.2151
195.089543287 | - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
- Nasrallah HA, Donnelly EF, Bigelow LB, Rivera-Calimlim L, Rogol A, Potkin S, Rauscher FP, Wyatt RJ: Inhibition of dopamine synthesis in chronic schizophrenia. Clinical ineffectiveness of metyrosine. Arch Gen Psychiatry. 1977 Jun;34(6):649-55. [PubMed:17374 ]
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