| HMDB0000121 | Folic acid | 59-30-3 |  | C19H19N7O6 | 441.3975
441.139681375 | - West AA, Caudill MA: Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29. doi: 10.1024/0300-9831/a000040. [PubMed:21462116 ]
- Kim YI: Role of the MTHFR polymorphisms in cancer risk modification and treatment. Future Oncol. 2009 May;5(4):523-42. doi: 10.2217/fon.09.26. [PubMed:19450180 ]
|
| HMDB0000217 | NADP | 53-59-8 |  | C21H28N7O17P3 | 743.405
743.075452041 | Not Available |
| HMDB0000221 | NADPH | 53-57-6 |  | C21H30N7O17P3 | 745.4209
745.091102105 | Not Available |
| HMDB0000239 | Pyridoxine | 65-23-6 |  | C8H11NO3 | 169.1778
169.073893223 | Not Available |
| HMDB0000244 | Riboflavin | 83-88-5 |  | C17H20N4O6 | 376.3639
376.138284392 | - Bates CJ, Fuller NJ: The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.20) and folate metabolism in the rat. Br J Nutr. 1986 Mar;55(2):455-64. [PubMed:3676170 ]
- Macdonald HM, McGuigan FE, Fraser WD, New SA, Ralston SH, Reid DM: Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density. Bone. 2004 Oct;35(4):957-64. [PubMed:15454103 ]
|
| HMDB0000607 | Cyanocobalamin | 68-19-9 |  | C63H89CoN14O14P | 1356.3731
1355.575230332 | - Nakamura T, Saionji K, Hiejima Y, Hirayama H, Tago K, Takano H, Tajiri M, Hayashi K, Kawabata M, Funamizu M, Makita Y, Hata A: Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients. Am J Kidney Dis. 2002 May;39(5):1032-9. [PubMed:11979347 ]
- Erdogan MO, Yildiz SH, Solak M, Eser O, Cosar E, Eser B, Koken R, Buyukbas S: C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects. Genet Mol Res. 2010 Jun 22;9(2):1197-203. doi: 10.4238/vol9-2gmr816. [PubMed:20589617 ]
|
| HMDB0000696 | Methionine | 63-68-3 |  | C5H11NO2S | 149.211
149.051049291 | - Lor KL, Cossins EA: Regulation of C metabolism by L-methionine in Saccharomyces cerevisiae. Biochem J. 1972 Dec;130(3):773-83. [PubMed:4198357 ]
|
| HMDB0000902 | NAD | 53-84-9 |  | C21H27N7O14P2 | 663.4251
663.109121631 | Not Available |
| HMDB0001248 | FAD | 146-14-5 |  | C27H33N9O15P2 | 785.5497
785.157134455 | Not Available |
| HMDB0001396 | 5-Methyltetrahydrofolic acid | 134-35-0 |  | C20H25N7O6 | 459.4558
459.186631567 | Not Available |
| HMDB0001487 | NADH | 58-68-4 |  | C21H29N7O14P2 | 665.441
665.124771695 | Not Available |
| HMDB0001491 | Pyridoxal 5'-phosphate | 54-47-7 |  | C8H10NO6P | 247.1419
247.024573569 | Not Available |
| HMDB0001533 | 5,10-Methylene-THF | 31690-11-6 |  | C20H23N7O6 | 457.4399
457.170981503 | Not Available |
| HMDB0001846 | Tetrahydrofolic acid | 135-16-0 |  | C19H23N7O6 | 445.4292
445.170981503 | Not Available |
| HMDB0001892 | Menadione | 58-27-5 |  | C11H8O2 | 172.18
172.0524295 | - Vanoni MA, Ballou DP, Matthews RG: Methylenetetrahydrofolate reductase. Steady state and rapid reaction studies on the NADPH-methylenetetrahydrofolate, NADPH-menadione, and methyltetrahydrofolate-menadione oxidoreductase activities of the enzyme. J Biol Chem. 1983 Oct 10;258(19):11510-4. [PubMed:6352699 ]
- Clark JE, Ljungdahl LG: Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum. J Biol Chem. 1984 Sep 10;259(17):10845-9. [PubMed:6381490 ]
|
| HMDB0014682 | Benazepril | 86541-75-5 |  | C24H28N2O5 | 424.4895
424.199822016 | - Jiang S, Yu Y, Venners SA, Zhang Y, Xing H, Wang X, Xu X: Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients. J Hum Hypertens. 2011 Mar;25(3):172-7. doi: 10.1038/jhh.2010.50. Epub 2010 May 6. [PubMed:20445573 ]
- Jiang S, Hsu YH, Niu T, Xu X, Xing H, Chen C, Wang X, Zhang Y, Peng S, Xu X: A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study. Clin Exp Hypertens. 2005 Aug;27(6):509-21. [PubMed:16081343 ]
- Jiang S, Hsu YH, Xu X, Xing H, Chen C, Niu T, Zhang Y, Peng S, Xu X: The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor. Thromb Res. 2004;113(6):361-9. [PubMed:15226090 ]
|
| HMDB0014684 | Fluorouracil | 51-21-8 |  | C4H3FN2O2 | 130.0772
130.017855555 | - Scartozzi M, Maccaroni E, Giampieri R, Pistelli M, Bittoni A, Del Prete M, Berardi R, Cascinu S: 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65. doi: 10.2217/pgs.10.167. [PubMed:21332317 ]
|
| HMDB0014703 | Methotrexate | 59-05-2 |  | C20H22N8O5 | 454.4393
454.171315854 | - Hider SL, Bruce IN, Thomson W: The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. Epub 2007 Jun 24. [PubMed:17586865 ]
- Kremer JM: Methotrexate pharmacogenomics. Ann Rheum Dis. 2006 Sep;65(9):1121-3. [PubMed:16905578 ]
|
| HMDB0059597 | Hydrogen Ion | |  | H | 1.0079
1.007825032 | Not Available |
