Hmdb loader

HMDB0001256 (Spermine) Protein Associations

Displaying metabolite protein links 1 - 25 of 26 in total
HMDBP ID Name UniProt ID Gene Name Locus Type References
HMDBP00015Diamine acetyltransferase 2Q96F10 SAT217p13.1Enzyme
  1. Chen Y, Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW: Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. Biochem J. 2003 Aug 1;373(Pt 3):661-7. [PubMed:12803540 ]
  2. Limsuwun K, Jones PG: Spermidine acetyltransferase is required to prevent spermidine toxicity at low temperatures in Escherichia coli. J Bacteriol. 2000 Oct;182(19):5373-80. [PubMed:10986239 ]
  3. Coleman CS, Stanley BA, Jones AD, Pegg AE: Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. Biochem J. 2004 Nov 15;384(Pt 1):139-48. [PubMed:15283699 ]
  4. Vogel NL, Boeke M, Ashburner BP: Spermidine/Spermine N1-Acetyltransferase 2 (SSAT2) functions as a coactivator for NF-kappaB and cooperates with CBP and P/CAF to enhance NF-kappaB-dependent transcription. Biochim Biophys Acta. 2006 Oct;1759(10):470-7. Epub 2006 Aug 30. [PubMed:17011643 ]
HMDBP00029Diamine acetyltransferase 1P21673 SAT1Xp22.1Enzyme
  1. Vujcic S, Halmekyto M, Diegelman P, Gan G, Kramer DL, Janne J, Porter CW: Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs. J Biol Chem. 2000 Dec 8;275(49):38319-28. [PubMed:10978316 ]
  2. Hegardt C, Andersson G, Oredsson SM: Changes in polyamine metabolism during glucocorticoid-induced programmed cell death in mouse thymus. Cell Biol Int. 2000;24(12):871-80. [PubMed:11114236 ]
  3. Marverti G, Bettuzzi S, Astancolle S, Pinna C, Monti MG, Moruzzi MS: Differential induction of spermidine/spermine N1-acetyltransferase activity in cisplatin-sensitive and -resistant ovarian cancer cells in response to N1,N12-bis(ethyl)spermine involves transcriptional and post-transcriptional regulation. Eur J Cancer. 2001 Jan;37(2):281-9. [PubMed:11166157 ]
  4. Scorcioni F, Corti A, Davalli P, Astancolle S, Bettuzzi S: Manipulation of the expression of regulatory genes of polyamine metabolism results in specific alterations of the cell-cycle progression. Biochem J. 2001 Feb 15;354(Pt 1):217-23. [PubMed:11171097 ]
  5. Min SH, Simmen RC, Alhonen L, Halmekyto M, Porter CW, Janne J, Simmen FA: Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT). J Biol Chem. 2002 Feb 1;277(5):3647-57. Epub 2001 Nov 14. [PubMed:11709547 ]
  6. Limsuwun K, Jones PG: Spermidine acetyltransferase is required to prevent spermidine toxicity at low temperatures in Escherichia coli. J Bacteriol. 2000 Oct;182(19):5373-80. [PubMed:10986239 ]
HMDBP00181Xanthine dehydrogenase/oxidaseP47989 XDH2p23.1Unknown
  1. Lovaas E, Carlin G: Spermine: an anti-oxidant and anti-inflammatory agent. Free Radic Biol Med. 1991;11(5):455-61. [PubMed:1663062 ]
HMDBP00201Choline dehydrogenase, mitochondrialQ8NE62 CHDH3p21.1UnknownNot Available
HMDBP00203Dimethylglycine dehydrogenase, mitochondrialQ9UI17 DMGDH5q14.1UnknownNot Available
HMDBP00217Spermine synthaseP52788 SMSXp22.1Enzyme
  1. Cason AL, Ikeguchi Y, Skinner C, Wood TC, Holden KR, Lubs HA, Martinez F, Simensen RJ, Stevenson RE, Pegg AE, Schwartz CE: X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet. 2003 Dec;11(12):937-44. [PubMed:14508504 ]
  2. Korhonen VP, Niiranen K, Halmekyto M, Pietila M, Diegelman P, Parkkinen JJ, Eloranta T, Porter CW, Alhonen L, Janne J: Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8. [PubMed:11160858 ]
  3. Lopatin AN, Shantz LM, Mackintosh CA, Nichols CG, Pegg AE: Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. J Mol Cell Cardiol. 2000 Nov;32(11):2007-24. [PubMed:11040105 ]
  4. Wang X, Ikeguchi Y, McCloskey DE, Nelson P, Pegg AE: Spermine synthesis is required for normal viability, growth, and fertility in the mouse. J Biol Chem. 2004 Dec 3;279(49):51370-5. Epub 2004 Sep 30. [PubMed:15459188 ]
  5. Schwartz CE, Wang X, Stevenson RE, Pegg AE: Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome). Methods Mol Biol. 2011;720:437-45. doi: 10.1007/978-1-61779-034-8_28. [PubMed:21318891 ]
  6. Wang X, Pegg AE: Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine. Methods Mol Biol. 2011;720:159-70. doi: 10.1007/978-1-61779-034-8_9. [PubMed:21318872 ]
  7. Theiss C, Bohley P, Voigt J: Regulation by polyamines of ornithine decarboxylase activity and cell division in the unicellular green alga Chlamydomonas reinhardtii. Plant Physiol. 2002 Apr;128(4):1470-9. [PubMed:11950995 ]
  8. Krauss M, Langnaese K, Richter K, Brunk I, Wieske M, Ahnert-Hilger G, Veh RW, Laube G: Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment. J Neurochem. 2006 Apr;97(1):174-89. Epub 2006 Mar 3. [PubMed:16515550 ]
  9. Kobayashi M, Takao K, Shiota Y, Sugita Y, Takahashi M, Nakae D, Samejima K: Inhibition of putrescine aminopropyltransferase influences rat liver regeneration. Biol Pharm Bull. 2006 May;29(5):863-7. [PubMed:16651710 ]
HMDBP00218Spermidine synthaseP19623 SRM1p36-p22EnzymeNot Available
HMDBP002914-trimethylaminobutyraldehyde dehydrogenaseP49189 ALDH9A11q23.1UnknownNot Available
HMDBP00382Gamma-butyrobetaine dioxygenaseO75936 BBOX111p14.2UnknownNot Available
HMDBP00390Amiloride-sensitive amine oxidase [copper-containing]P19801 ABP17q36.1UnknownNot Available
HMDBP00397S-methyl-5'-thioadenosine phosphorylaseQ13126 MTAP9p21EnzymeNot Available
HMDBP00420S-adenosylmethionine decarboxylase proenzymeP17707 AMD16q21UnknownNot Available
HMDBP00463Glycine amidinotransferase, mitochondrialP50440 GATM15q21.1EnzymeNot Available
HMDBP00559Betaine--homocysteine S-methyltransferase 1Q93088 BHMT5q14.1UnknownNot Available
HMDBP00793Sarcosine dehydrogenase, mitochondrialQ9UL12 SARDH9q33-q34UnknownNot Available
HMDBP00885Histidine decarboxylaseP19113 HDC15q21-q22EnzymeNot Available
HMDBP01034Ornithine decarboxylaseP11926 ODC12p25Enzyme
  1. Nilsson J, Grahn B, Heby O: Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression. Biochem J. 2000 Mar 15;346 Pt 3:699-704. [PubMed:10698696 ]
  2. Ray RM, Viar MJ, Yuan Q, Johnson LR: Polyamine depletion delays apoptosis of rat intestinal epithelial cells. Am J Physiol Cell Physiol. 2000 Mar;278(3):C480-9. [PubMed:10712236 ]
  3. Korhonen VP, Niiranen K, Halmekyto M, Pietila M, Diegelman P, Parkkinen JJ, Eloranta T, Porter CW, Alhonen L, Janne J: Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8. [PubMed:11160858 ]
  4. Rohn G, Els T, Hell K, Ernestus RI: Regional distribution of ornithine decarboxylase activity and polyamine levels in experimental cat brain tumors. Neurochem Int. 2001 Aug;39(2):135-40. [PubMed:11408092 ]
  5. Ernestus RI, Rohn G, Schroder R, Els T, Klekner A, Paschen W, Klug N: Polyamine metabolism in brain tumours: diagnostic relevance of quantitative biochemistry. J Neurol Neurosurg Psychiatry. 2001 Jul;71(1):88-92. [PubMed:11413269 ]
  6. [No authors listed] [PubMed:21140446 ]
HMDBP02439Solute carrier family 22 member 4Q9H015 SLC22A45q31.1Transporter
  1. Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. [PubMed:10215651 ]
HMDBP02574Solute carrier family 22 member 1O15245 SLC22A16q26Transporter
  1. Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem. 1996 Dec 20;271(51):32599-604. [PubMed:8955087 ]
HMDBP02634Spermine oxidaseQ9NWM0 SMOX20p13Unknown
  1. Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW: Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem J. 2003 Feb 15;370(Pt 1):19-28. [PubMed:12477380 ]
  2. Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA Jr: Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. Biochem Biophys Res Commun. 2003 May 16;304(4):605-11. [PubMed:12727196 ]
  3. Vujcic S, Diegelman P, Bacchi CJ, Kramer DL, Porter CW: Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J. 2002 Nov 1;367(Pt 3):665-75. [PubMed:12141946 ]
  4. Binda C, Angelini R, Federico R, Ascenzi P, Mattevi A: Structural bases for inhibitor binding and catalysis in polyamine oxidase. Biochemistry. 2001 Mar 6;40(9):2766-76. [PubMed:11258887 ]
  5. Bacchi CJ, Rattendi D, Faciane E, Yarlett N, Weiss LM, Frydman B, Woster P, Wei B, Marton LJ, Wittner M: Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues. Microbiology. 2004 May;150(Pt 5):1215-24. [PubMed:15133083 ]
HMDBP02696Agmatinase, mitochondrialQ9BSE5 AGMAT1p36.21UnknownNot Available
HMDBP03654Trimethyllysine dioxygenase, mitochondrialQ9NVH6 TMLHEXq28UnknownNot Available
HMDBP04296S-methylmethionine--homocysteine S-methyltransferase BHMT2Q9H2M3 BHMT25q13UnknownNot Available
HMDBP08787Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrialQ8NCN5 PDPR16q22.1UnknownNot Available
HMDBP10709Ornithine decarboxylase antizyme 1P54368 OAZ119p13.3EnzymeNot Available
Displaying metabolite protein links 1 - 25 of 26 in total