| Identification |
|---|
| HMDB Protein ID
| HMDBP13612 |
| Secondary Accession Numbers
| None |
| Name
| Hydroxymethylglutaryl-CoA synthase |
| Synonyms
|
- HMG-CoA synthase
- 3-hydroxy-3-methylglutaryl coenzyme A synthase
|
| Gene Name
| HMGS-1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. |
| Pathways
|
- (R)-mevalonate biosynthesis
- Butanoate metabolism
- Terpenoid backbone biosynthesis
- Valine, leucine and isoleucine degradation
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| sterol biosynthetic process |
| farnesyl diphosphate biosynthetic process, mevalonate pathway |
| acetyl-CoA metabolic process |
| Molecular Function |
| hydroxymethylglutaryl-CoA synthase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 462 |
| Molecular Weight
| 51415.085 |
| Theoretical pI
| 6.261 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P54871 |
| UniProtKB/Swiss-Prot Entry Name
| HMCS_CAEEL |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Boukaftane Y, Duncan A, Wang S, Labuda D, Robert MF, Sarrazin J, Schappert K, Mitchell GA: Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution. Genomics. 1994 Oct;23(3):552-9. [PubMed:7851882 ]
- Authors unspecified: Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998 Dec 11;282(5396):2012-8. doi: 10.1126/science.282.5396.2012. [PubMed:9851916 ]
- Sapir A, Tsur A, Koorman T, Ching K, Mishra P, Bardenheier A, Podolsky L, Bening-Abu-Shach U, Boxem M, Chou TF, Broday L, Sternberg PW: Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3880-9. doi: 10.1073/pnas.1414748111. Epub 2014 Sep 3. [PubMed:25187565 ]
|
