| Identification |
|---|
| HMDB Protein ID
| HMDBP13452 |
| Secondary Accession Numbers
| None |
| Name
| Phosphoribosylformylglycinamidine synthase subunit PurQ |
| Synonyms
|
- FGAM synthase
- Formylglycinamide ribonucleotide amidotransferase subunit I
- Glutaminase PurQ
- Phosphoribosylformylglycinamidine synthase subunit I
- FGAR amidotransferase I
- FGAR-AT I
|
| Gene Name
| PURQ |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. |
| Pathways
|
- Alanine, aspartate and glutamate metabolism
- Arginine biosynthesis
- Biosynthesis of secondary metabolites
- D-Amino acid metabolism
- IMP biosynthesis via de novo pathway
- Purine metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| glutamine metabolic process |
| 'de novo' IMP biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| ATP binding |
| phosphoribosylformylglycinamidine synthase activity |
| glutaminase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 223 |
| Molecular Weight
| 23726.61 |
| Theoretical pI
| 5.043 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q4JXF1 |
| UniProtKB/Swiss-Prot Entry Name
| PURQ_CORJK |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tauch A, Kaiser O, Hain T, Goesmann A, Weisshaar B, Albersmeier A, Bekel T, Bischoff N, Brune I, Chakraborty T, Kalinowski J, Meyer F, Rupp O, Schneiker S, Viehoever P, Puhler A: Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. J Bacteriol. 2005 Jul;187(13):4671-82. doi: 10.1128/JB.187.13.4671-4682.2005. [PubMed:15968079 ]
|
