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Showing Protein Activated CDC42 kinase 1 (HMDBP13422)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13422
Secondary Accession Numbers None
Name Activated CDC42 kinase 1
Synonyms
  1. ACK-1
  2. Non-receptor protein tyrosine kinase Ack
  3. Tyrosine kinase non-receptor protein 2
Gene Name TNK2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
spermatid development
positive regulation of peptidyl-tyrosine phosphorylation
innate immune response
transmembrane receptor protein tyrosine kinase signaling pathway
cell differentiation
regulation of clathrin-dependent endocytosis
endocytosis
phosphorylation
Cellular Component
cytosol
growth cone
cytoplasm
plasma membrane
dendrite
nucleus
cytoplasmic vesicle membrane
clathrin-coated vesicle
coated pit
adherens junction
neuronal cell body
cytoophidium
Grb2-EGFR complex
axon
extrinsic to internal side of plasma membrane
endosome
Molecular Function
transmembrane receptor protein tyrosine kinase activity
metal ion binding
epidermal growth factor receptor binding
protein tyrosine kinase activity
WW domain binding
ATP binding
ubiquitin protein ligase binding
receptor binding
protein serine/threonine/tyrosine kinase activity
protein serine kinase activity
protein threonine kinase activity
non-membrane spanning protein tyrosine kinase activity
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 1055
Molecular Weight 116974.41
Theoretical pI 7.436
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O54967
UniProtKB/Swiss-Prot Entry Name ACK1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Shen F, Lin Q, Gu Y, Childress C, Yang W: Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol Biol Cell. 2007 Mar;18(3):732-42. Epub 2006 Dec 20. [PubMed:17182860 ]
  4. Eley L, Moochhala SH, Simms R, Hildebrandt F, Sayer JA: Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct. Biochem Biophys Res Commun. 2008 Jul 11;371(4):877-82. doi: 10.1016/j.bbrc.2008.05.016. Epub 2008 May 12. [PubMed:18477472 ]
  5. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  6. Ballif BA, Carey GR, Sunyaev SR, Gygi SP: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. J Proteome Res. 2008 Jan;7(1):311-8. doi: 10.1021/pr0701254. Epub 2007 Nov 23. [PubMed:18034455 ]
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  9. Galisteo ML, Yang Y, Urena J, Schlessinger J: Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9796-801. doi: 10.1073/pnas.0603714103. Epub 2006 Jun 15. [PubMed:16777958 ]
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  14. Strochlic TI, Stavrides KP, Thomas SV, Nicolas E, O'Reilly AM, Peterson JR: Ack kinase regulates CTP synthase filaments during Drosophila oogenesis. EMBO Rep. 2014 Nov;15(11):1184-91. doi: 10.15252/embr.201438688. Epub 2014 Sep 15. [PubMed:25223282 ]