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Showing Protein Protein arginine N-methyltransferase 7 (HMDBP13354)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13354
Secondary Accession Numbers None
Name Protein arginine N-methyltransferase 7
Synonyms
  1. Histone-arginine N-methyltransferase PRMT7
  2. [Myelin basic protein]-arginine N-methyltransferase PRMT7
Gene Name PRMT7
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
peptidyl-arginine methylation
epiboly involved in gastrulation with mouth forming second
histone arginine methylation
cytoskeleton organization
spliceosomal snRNP assembly
cell differentiation
DNA methylation involved in gamete generation
regulation of gene expression by genetic imprinting
Cellular Component
cytosol
nucleus
Molecular Function
S-adenosylmethionine-dependent methyltransferase activity
histone methyltransferase activity (H4-R3 specific)
protein-arginine omega-N symmetric methyltransferase activity
protein-arginine omega-N monomethyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 683
Molecular Weight 76546.02
Theoretical pI 5.054
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A2AV36
UniProtKB/Swiss-Prot Entry Name ANM7_DANRE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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