| Identification |
|---|
| HMDB Protein ID
| HMDBP12816 |
| Secondary Accession Numbers
| None |
| Name
| Sulfite efflux pump SSU1 |
| Synonyms
|
Not Available
|
| Gene Name
| SSU1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump represents also an detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| transmembrane transport |
| Cellular Component |
| plasma membrane |
| integral to membrane |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 220 |
| Molecular Weight
| 41843.58 |
| Theoretical pI
| 9.18 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 26-46;60-80;102-122;136-156;168-188;201-221;235-255;278-298;310-330;344-364;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A3R044 |
| UniProtKB/Swiss-Prot Entry Name
| SSU1_ARTBC |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Burmester A, Shelest E, Glockner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wostemeyer J, Zipfel PF, Monod M, Brakhage AA: Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol. 2011;12(1):R7. doi: 10.1186/gb-2011-12-1-r7. Epub 2011 Jan 19. [PubMed:21247460 ]
- Lechenne B, Reichard U, Zaugg C, Fratti M, Kunert J, Boulat O, Monod M: Sulphite efflux pumps in Aspergillus fumigatus and dermatophytes. Microbiology (Reading). 2007 Mar;153(Pt 3):905-913. doi: 10.1099/mic.0.2006/003335-0. [PubMed:17322211 ]
- Grumbt M, Monod M, Yamada T, Hertweck C, Kunert J, Staib P: Keratin degradation by dermatophytes relies on cysteine dioxygenase and a sulfite efflux pump. J Invest Dermatol. 2013 Jun;133(6):1550-5. doi: 10.1038/jid.2013.41. Epub 2013 Jan 25. [PubMed:23353986 ]
|
