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Showing Protein DNA polymerase eta (HMDBP12798)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP12798
Secondary Accession Numbers None
Name DNA polymerase eta
Synonyms
  1. Radiation-sensitive protein 30
  2. Y-family DNA polymerase H
  3. AtRAD30
  4. AtPOLH
Gene Name POLH
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Exhibits cyclobutane dimer nonmutagenic bypass activity in vitro.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
DNA replication
response to UV-B
error-prone translesion synthesis
response to radiation
UV protection
Cellular Component
site of double-strand break
nucleus
replication fork
Molecular Function
metal ion binding
DNA-directed DNA polymerase activity
damaged DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 672
Molecular Weight 73984.555
Theoretical pI 6.571
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8H2D5
UniProtKB/Swiss-Prot Entry Name POLH_ARATH
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Santiago MJ, Alejandre-Duran E, Ruiz-Rubio M: Analysis of UV-induced mutation spectra in Escherichia coli by DNA polymerase eta from Arabidopsis thaliana. Mutat Res. 2006 Oct 10;601(1-2):51-60. doi: 10.1016/j.mrfmmm.2006.05.036. Epub 2006 Jul 20. [PubMed:16857217 ]
  2. Anderson HJ, Vonarx EJ, Pastushok L, Nakagawa M, Katafuchi A, Gruz P, Di Rubbo A, Grice DM, Osmond MJ, Sakamoto AN, Nohmi T, Xiao W, Kunz BA: Arabidopsis thaliana Y-family DNA polymerase eta catalyses translesion synthesis and interacts functionally with PCNA2. Plant J. 2008 Sep;55(6):895-908. doi: 10.1111/j.1365-313X.2008.03562.x. Epub 2008 May 20. [PubMed:18494853 ]
  3. Asamizu E, Sato S, Kaneko T, Nakamura Y, Kotani H, Miyajima N, Tabata S: Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones. DNA Res. 1998 Dec 31;5(6):379-91. doi: 10.1093/dnares/5.6.379. [PubMed:10048488 ]
  4. Tabata S, Kaneko T, Nakamura Y, Kotani H, Kato T, Asamizu E, Miyajima N, Sasamoto S, Kimura T, Hosouchi T, Kawashima K, Kohara M, Matsumoto M, Matsuno A, Muraki A, Nakayama S, Nakazaki N, Naruo K, Okumura S, Shinpo S, Takeuchi C, Wada T, Watanabe A, Yamada M, Yasuda M, Sato S, de la Bastide M, Huang E, Spiegel L, Gnoj L, O'Shaughnessy A, Preston R, Habermann K, Murray J, Johnson D, Rohlfing T, Nelson J, Stoneking T, Pepin K, Spieth J, Sekhon M, Armstrong J, Becker M, Belter E, Cordum H, Cordes M, Courtney L, Courtney W, Dante M, Du H, Edwards J, Fryman J, Haakensen B, Lamar E, Latreille P, Leonard S, Meyer R, Mulvaney E, Ozersky P, Riley A, Strowmatt C, Wagner-McPherson C, Wollam A, Yoakum M, Bell M, Dedhia N, Parnell L, Shah R, Rodriguez M, See LH, Vil D, Baker J, Kirchoff K, Toth K, King L, Bahret A, Miller B, Marra M, Martienssen R, McCombie WR, Wilson RK, Murphy G, Bancroft I, Volckaert G, Wambutt R, Dusterhoft A, Stiekema W, Pohl T, Entian KD, Terryn N, Hartley N, Bent E, Johnson S, Langham SA, McCullagh B, Robben J, Grymonprez B, Zimmermann W, Ramsperger U, Wedler H, Balke K, Wedler E, Peters S, van Staveren M, Dirkse W, Mooijman P, Lankhorst RK, Weitzenegger T, Bothe G, Rose M, Hauf J, Berneiser S, Hempel S, Feldpausch M, Lamberth S, Villarroel R, Gielen J, Ardiles W, Bents O, Lemcke K, Kolesov G, Mayer K, Rudd S, Schoof H, Schueller C, Zaccaria P, Mewes HW, Bevan M, Fransz P: Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature. 2000 Dec 14;408(6814):823-6. doi: 10.1038/35048507. [PubMed:11130714 ]
  5. Cheng CY, Krishnakumar V, Chan AP, Thibaud-Nissen F, Schobel S, Town CD: Araport11: a complete reannotation of the Arabidopsis thaliana reference genome. Plant J. 2017 Feb;89(4):789-804. doi: 10.1111/tpj.13415. Epub 2017 Feb 10. [PubMed:27862469 ]
  6. Yamada K, Lim J, Dale JM, Chen H, Shinn P, Palm CJ, Southwick AM, Wu HC, Kim C, Nguyen M, Pham P, Cheuk R, Karlin-Newmann G, Liu SX, Lam B, Sakano H, Wu T, Yu G, Miranda M, Quach HL, Tripp M, Chang CH, Lee JM, Toriumi M, Chan MM, Tang CC, Onodera CS, Deng JM, Akiyama K, Ansari Y, Arakawa T, Banh J, Banno F, Bowser L, Brooks S, Carninci P, Chao Q, Choy N, Enju A, Goldsmith AD, Gurjal M, Hansen NF, Hayashizaki Y, Johnson-Hopson C, Hsuan VW, Iida K, Karnes M, Khan S, Koesema E, Ishida J, Jiang PX, Jones T, Kawai J, Kamiya A, Meyers C, Nakajima M, Narusaka M, Seki M, Sakurai T, Satou M, Tamse R, Vaysberg M, Wallender EK, Wong C, Yamamura Y, Yuan S, Shinozaki K, Davis RW, Theologis A, Ecker JR: Empirical analysis of transcriptional activity in the Arabidopsis genome. Science. 2003 Oct 31;302(5646):842-6. doi: 10.1126/science.1088305. [PubMed:14593172 ]
  7. Kunz BA, Anderson HJ, Osmond MJ, Vonarx EJ: Components of nucleotide excision repair and DNA damage tolerance in Arabidopsis thaliana. Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):115-27. doi: 10.1002/em.20094. [PubMed:15645454 ]
  8. Hoffman PD, Curtis MJ, Iwai S, Hays JB: Biochemical evolution of DNA polymerase eta: properties of plant, human, and yeast proteins. Biochemistry. 2008 Apr 22;47(16):4583-96. doi: 10.1021/bi701781p. Epub 2008 Mar 27. [PubMed:18366182 ]
  9. Jesus Santiago M, Alejandre-Duran E, Munoz-Serrano A, Ruiz-Rubio M: Two translesion synthesis DNA polymerase genes, AtPOLH and AtREV1, are involved in development and UV light resistance in Arabidopsis. J Plant Physiol. 2008 Oct 9;165(15):1582-91. doi: 10.1016/j.jplph.2007.11.012. Epub 2008 Mar 14. [PubMed:18339443 ]
  10. Nakagawa M, Takahashi S, Tanaka A, Narumi I, Sakamoto AN: Role of AtPolzeta, AtRev1, and AtPoleta in UV light-induced mutagenesis in Arabidopsis. Plant Physiol. 2011 Jan;155(1):414-20. doi: 10.1104/pp.110.166082. Epub 2010 Oct 28. [PubMed:21030509 ]
  11. Nakagawa M, Takahashi S, Narumi I, Sakamoto AN: Role of AtPolzeta, AtRev1 and AtPoleta in gamma ray-induced mutagenesis. Plant Signal Behav. 2011 May;6(5):728-31. doi: 10.4161/psb.6.5.15124. Epub 2011 May 1. [PubMed:21455019 ]