| Identification |
|---|
| HMDB Protein ID
| HMDBP12562 |
| Secondary Accession Numbers
| None |
| Name
| Arginine deiminase |
| Synonyms
|
- ADI
- Arginine dihydrolase
- Streptococcal acid glycoprotein
- AD
|
| Gene Name
| ARCA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Antitumor protein. Has a powerful and dose-dependent inhibitory effect on antigen, superantigen, or mitogen-stimulated human peripheral blood mononuclear cell (PBMC) proliferation. It may inhibit cell proliferation by arresting cell cycle and inducing apoptosis. |
| Pathways
|
- Arginine biosynthesis
- Biosynthesis of secondary metabolites
- L-arginine degradation via ADI pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| arginine catabolic process to ornithine |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| arginine deiminase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 411 |
| Molecular Weight
| 46310.43 |
| Theoretical pI
| 5.09 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P58827 |
| UniProtKB/Swiss-Prot Entry Name
| ARCA_STRPG |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Holden MT, Scott A, Cherevach I, Chillingworth T, Churcher C, Cronin A, Dowd L, Feltwell T, Hamlin N, Holroyd S, Jagels K, Moule S, Mungall K, Quail MA, Price C, Rabbinowitsch E, Sharp S, Skelton J, Whitehead S, Barrell BG, Kehoe M, Parkhill J: Complete genome of acute rheumatic fever-associated serotype M5 Streptococcus pyogenes strain manfredo. J Bacteriol. 2007 Feb;189(4):1473-7. doi: 10.1128/JB.01227-06. Epub 2006 Sep 29. [PubMed:17012393 ]
- Degnan BA, Palmer JM, Robson T, Jones CE, Fischer M, Glanville M, Mellor GD, Diamond AG, Kehoe MA, Goodacre JA: Inhibition of human peripheral blood mononuclear cell proliferation by Streptococcus pyogenes cell extract is associated with arginine deiminase activity. Infect Immun. 1998 Jul;66(7):3050-8. doi: 10.1128/IAI.66.7.3050-3058.1998. [PubMed:9632565 ]
|
