| Identification |
|---|
| HMDB Protein ID
| HMDBP12297 |
| Secondary Accession Numbers
| None |
| Name
| Vitamin K-dependent gamma-carboxylase |
| Synonyms
|
- Gamma-glutamyl carboxylase
- Peptidyl-glutamate 4-carboxylase
- Vitamin K gamma glutamyl carboxylase
|
| Gene Name
| GGCX |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. |
| Pathways
|
- Biosynthesis of cofactors
- Ubiquinone and other terpenoid-quinone biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| peptidyl-glutamic acid carboxylation |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Molecular Function |
| gamma-glutamyl carboxylase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 758 |
| Molecular Weight
| 87556.395 |
| Theoretical pI
| 8.318 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 61-81;114-134;137-157;293-313;364-384;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q07175 |
| UniProtKB/Swiss-Prot Entry Name
| VKGC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Wu SM, Cheung WF, Frazier D, Stafford DW: Cloning and expression of the cDNA for human gamma-glutamyl carboxylase. Science. 1991 Dec 13;254(5038):1634-6. [PubMed:1749935 ]
- Rehemtulla A, Roth DA, Wasley LC, Kuliopulos A, Walsh CT, Furie B, Furie BC, Kaufman RJ: In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4611-5. doi: 10.1073/pnas.90.10.4611. [PubMed:8506307 ]
|
