Hmdb loader
Identification
HMDB Protein ID HMDBP12176
Secondary Accession Numbers None
Name Lysophospholipase D GDPD3
Synonyms
  1. Glycerophosphodiester phosphodiesterase 7
  2. Glycerophosphodiester phosphodiesterase domain-containing protein 3
Gene Name GDPD3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.
Pathways
  • Ether lipid metabolism
Reactions Not Available
GO Classification
Biological Process
N-acylethanolamine metabolic process
phosphatidylcholine catabolic process
glycerophospholipid catabolic process
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum
extracellular vesicular exosome
perinuclear region of cytoplasm
integral to membrane
Molecular Function
phosphoric diester hydrolase activity
metal ion binding
lysophospholipase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 318
Molecular Weight 36595.955
Theoretical pI 7.975
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 3-23;199-221;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q7L5L3
UniProtKB/Swiss-Prot Entry Name GDPD3_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Rahman IA, Tsuboi K, Hussain Z, Yamashita R, Okamoto Y, Uyama T, Yamazaki N, Tanaka T, Tokumura A, Ueda N: Calcium-dependent generation of N-acylethanolamines and lysophosphatidic acids by glycerophosphodiesterase GDE7. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1881-1892. doi: 10.1016/j.bbalip.2016.09.008. Epub 2016 Sep 13. [PubMed:27637550 ]