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Showing Protein Lysophosphatidylcholine acyltransferase 1 (HMDBP12169)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP12169
Secondary Accession Numbers None
Name Lysophosphatidylcholine acyltransferase 1
Synonyms
  1. LPC acyltransferase 1
  2. LPCAT-1
  3. LysoPC acyltransferase 1
  4. 1-acylglycerol-3-phosphate O-acyltransferase
  5. 1-acylglycerophosphocholine O-acyltransferase
  6. 1-alkenylglycerophosphocholine O-acyltransferase
  7. 1-alkylglycerophosphocholine O-acetyltransferase
  8. Acetyl-CoA:lyso-platelet-activating factor acetyltransferase
  9. Acyltransferase-like 2
  10. Acetyl-CoA:lyso-PAF acetyltransferase
  11. Lyso-PAF acetyltransferase
  12. LysoPAFAT
Gene Name LPCAT1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Exhibits both acyltransferase and acetyltransferase activities (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).
Pathways
  • Ether lipid metabolism
  • Glycerophospholipid metabolism
  • phospholipid metabolism
Reactions Not Available
GO Classification
Biological Process
phospholipid biosynthetic process
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum
plasma membrane
Golgi apparatus
lipid particle
integral to membrane
Golgi membrane
Molecular Function
1-acylglycerol-3-phosphate O-acyltransferase activity
1-acylglycerophosphocholine O-acyltransferase activity
calcium ion binding
1-alkylglycerophosphocholine O-acetyltransferase activity
1-alkenylglycerophosphocholine O-acyltransferase activity
plasmalogen synthase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 517
Molecular Weight 58726.71
Theoretical pI 7.628
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 53-73;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q1LWG4
UniProtKB/Swiss-Prot Entry Name PCAT1_DANRE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett JC, Koch R, Rauch GJ, White S, Chow W, Kilian B, Quintais LT, Guerra-Assuncao JA, Zhou Y, Gu Y, Yen J, Vogel JH, Eyre T, Redmond S, Banerjee R, Chi J, Fu B, Langley E, Maguire SF, Laird GK, Lloyd D, Kenyon E, Donaldson S, Sehra H, Almeida-King J, Loveland J, Trevanion S, Jones M, Quail M, Willey D, Hunt A, Burton J, Sims S, McLay K, Plumb B, Davis J, Clee C, Oliver K, Clark R, Riddle C, Elliot D, Threadgold G, Harden G, Ware D, Begum S, Mortimore B, Kerry G, Heath P, Phillimore B, Tracey A, Corby N, Dunn M, Johnson C, Wood J, Clark S, Pelan S, Griffiths G, Smith M, Glithero R, Howden P, Barker N, Lloyd C, Stevens C, Harley J, Holt K, Panagiotidis G, Lovell J, Beasley H, Henderson C, Gordon D, Auger K, Wright D, Collins J, Raisen C, Dyer L, Leung K, Robertson L, Ambridge K, Leongamornlert D, McGuire S, Gilderthorp R, Griffiths C, Manthravadi D, Nichol S, Barker G, Whitehead S, Kay M, Brown J, Murnane C, Gray E, Humphries M, Sycamore N, Barker D, Saunders D, Wallis J, Babbage A, Hammond S, Mashreghi-Mohammadi M, Barr L, Martin S, Wray P, Ellington A, Matthews N, Ellwood M, Woodmansey R, Clark G, Cooper J, Tromans A, Grafham D, Skuce C, Pandian R, Andrews R, Harrison E, Kimberley A, Garnett J, Fosker N, Hall R, Garner P, Kelly D, Bird C, Palmer S, Gehring I, Berger A, Dooley CM, Ersan-Urun Z, Eser C, Geiger H, Geisler M, Karotki L, Kirn A, Konantz J, Konantz M, Oberlander M, Rudolph-Geiger S, Teucke M, Lanz C, Raddatz G, Osoegawa K, Zhu B, Rapp A, Widaa S, Langford C, Yang F, Schuster SC, Carter NP, Harrow J, Ning Z, Herrero J, Searle SM, Enright A, Geisler R, Plasterk RH, Lee C, Westerfield M, de Jong PJ, Zon LI, Postlethwait JH, Nusslein-Volhard C, Hubbard TJ, Roest Crollius H, Rogers J, Stemple DL: The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013 Apr 25;496(7446):498-503. doi: 10.1038/nature12111. Epub 2013 Apr 17. [PubMed:23594743 ]