| Identification |
|---|
| HMDB Protein ID
| HMDBP12110 |
| Secondary Accession Numbers
| None |
| Name
| Phosphatidylinositol:ceramide inositolphosphotransferase |
| Synonyms
|
- TbSLS1
- Inositol-phosphorylceramide synthase
- Sphingolipid synthase
- IPC synthase
|
| Gene Name
| SLS1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Bidirectional lipid inositolphosphotransferase capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoinositol acceptors. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| sphingolipid metabolic process |
| Cellular Component |
| integral to membrane |
| Molecular Function |
| kinase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 39853.57 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 45-65;90-110;166-186;206-226;230-250;276-296;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| B3A0L9 |
| UniProtKB/Swiss-Prot Entry Name
| SLS1_TRYBB |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sevova ES, Goren MA, Schwartz KJ, Hsu FF, Turk J, Fox BG, Bangs JD: Cell-free synthesis and functional characterization of sphingolipid synthases from parasitic trypanosomatid protozoa. J Biol Chem. 2010 Jul 2;285(27):20580-7. doi: 10.1074/jbc.M110.127662. Epub 2010 May 10. [PubMed:20457606 ]
- Sutterwala SS, Hsu FF, Sevova ES, Schwartz KJ, Zhang K, Key P, Turk J, Beverley SM, Bangs JD: Developmentally regulated sphingolipid synthesis in African trypanosomes. Mol Microbiol. 2008 Oct;70(2):281-96. doi: 10.1111/j.1365-2958.2008.06393.x. Epub 2008 Aug 11. [PubMed:18699867 ]
|
