| Identification |
|---|
| HMDB Protein ID
| HMDBP12096 |
| Secondary Accession Numbers
| None |
| Name
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
| Synonyms
|
- PLC-85
- Phosphoinositide phospholipase C-delta-4
- Phospholipase C-delta-2
- Phospholipase C-delta-4
- PLC-delta-2
- PLC-delta-4
|
| Gene Name
| PLCD4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity). |
| Pathways
|
- AGE-RAGE signaling pathway in diabetic complications
- Calcium signaling pathway
- Inositol phosphate metabolism
- Phosphatidylinositol signaling system
- Thyroid hormone signaling pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| lipid catabolic process |
| phosphatidylinositol metabolic process |
| acrosome reaction |
| intracellular signal transduction |
| Cellular Component |
| endoplasmic reticulum |
| nucleus |
| membrane |
| Molecular Function |
| G-protein alpha-subunit binding |
| phosphatidylinositol phospholipase C activity |
| calcium ion binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 791 |
| Molecular Weight
| 90580.0 |
| Theoretical pI
| 5.241 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P21671 |
| UniProtKB/Swiss-Prot Entry Name
| PLCD4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Meldrum E, Katan M, Parker P: A novel inositol-phospholipid-specific phospholipase C. Rapid purification and characterization. Eur J Biochem. 1989 Jul 1;182(3):673-7. doi: 10.1111/j.1432-1033.1989.tb14878.x. [PubMed:2753038 ]
- Irino Y, Cho H, Nakamura Y, Nakahara M, Furutani M, Suh PG, Takenawa T, Fukami K: Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdelta4. Biochem Biophys Res Commun. 2004 Jul 23;320(2):537-43. doi: 10.1016/j.bbrc.2004.05.206. [PubMed:15219862 ]
|
