| Identification |
|---|
| HMDB Protein ID
| HMDBP12092 |
| Secondary Accession Numbers
| None |
| Name
| Phosphatidylcholine:ceramide cholinephosphotransferase 3 |
| Synonyms
|
- TbSLS3
- Ethanolamine-phosphorylceramide synthase
- Sphingolipid synthase
- Sphingomyelin synthase
- EPC synthase
- SM synthase
|
| Gene Name
| SLS3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| sphingolipid metabolic process |
| Cellular Component |
| integral to membrane |
| Molecular Function |
| sphingomyelin synthase activity |
| kinase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 37083.4 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 27-47;75-95;148-168;212-232;234-254;258-278;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| B3A0M1 |
| UniProtKB/Swiss-Prot Entry Name
| SLS3_TRYBB |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sevova ES, Goren MA, Schwartz KJ, Hsu FF, Turk J, Fox BG, Bangs JD: Cell-free synthesis and functional characterization of sphingolipid synthases from parasitic trypanosomatid protozoa. J Biol Chem. 2010 Jul 2;285(27):20580-7. doi: 10.1074/jbc.M110.127662. Epub 2010 May 10. [PubMed:20457606 ]
- Sutterwala SS, Hsu FF, Sevova ES, Schwartz KJ, Zhang K, Key P, Turk J, Beverley SM, Bangs JD: Developmentally regulated sphingolipid synthesis in African trypanosomes. Mol Microbiol. 2008 Oct;70(2):281-96. doi: 10.1111/j.1365-2958.2008.06393.x. Epub 2008 Aug 11. [PubMed:18699867 ]
|
