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Showing Protein Dual specificity protein phosphatase 22 (HMDBP11721)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP11721
Secondary Accession Numbers None
Name Dual specificity protein phosphatase 22
Synonyms
  1. JNK-stimulatory phosphatase-1
  2. Low molecular weight dual specificity phosphatase 2
  3. Mitogen-activated protein kinase phosphatase x
  4. JSP-1
  5. LMW-DSP2
  6. MAP kinase phosphatase x
  7. MKP-x
Gene Name DUSP22
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).
Pathways
  • MAPK signaling pathway
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
A phosphoprotein + Water → a protein + Phosphate details
GO Classification
Biological Process
multicellular organismal development
regulation of cell proliferation
apoptotic process
cell proliferation
negative regulation of transcription from RNA polymerase II promoter
inactivation of MAPK activity
positive regulation of JNK cascade
transforming growth factor beta receptor signaling pathway
peptidyl-tyrosine dephosphorylation
Cellular Component
cytoplasm
nucleus
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 6
Locus 6p25.3
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 20909.845
Theoretical pI 8.105
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>>gi|9910432|ref|NP_064570.1| dual specificity protein phosphatase 22 [Homo sapiens]
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPS
QNLTRHFKES
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NRW4
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:16077
References
General References Not Available