| Identification |
|---|
| HMDB Protein ID
| HMDBP11510 |
| Secondary Accession Numbers
| |
| Name
| Guanine nucleotide-binding protein G(olf) subunit alpha |
| Synonyms
|
- Adenylate cyclase-stimulating G alpha protein, olfactory type
|
| Gene Name
| GNAL |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in signal transducer activity |
| Specific Function
| Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| molecular transducer activity |
| signal transducer activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18p11.22-p11.21 |
| SNPs
| GNAL |
| Gene Sequence
|
>1146 bp
ATGGGGTGTTTGGGCGGCAACAGCAAGACGACGGAAGACCAGGGCGTCGATGAAAAAGAA
CGACGCGAGGCCAACAAAAAGATCGAGAAGCAGTTGCAGAAAGAGCGCCTGGCTTACAAG
GCTACCCACCGCCTGCTGCTCCTGGGGGCTGGTGAGTCTGGGAAAAGCACTATCGTCAAA
CAGATGAGGATCCTGCACGTCAATGGGTTTAATCCCGAGGAAAAGAAACAGAAAATTCTG
GACATCCGGAAAAATGTTAAAGATGCTATCGTGACAATTGTTTCAGCAATGAGTACTATA
ATACCTCCAGTTCCGCTGGCCAACCCTGAAAACCAATTTCGATCAGACTACATCAAGAGC
ATAGCCCCTATCACTGACTTTGAATATTCCCAGGAATTCTTTGACCATGTGAAAAAACTT
TGGGACGATGAAGGCGTGAAGGCATGCTTTGAGAGATCCAACGAATACCAGCTGATTGAC
TGTGCACAATACTTCCTGGAAAGAATCGACAGCGTCAGCTTGGTTGACTACACACCCACA
GACCAGGACCTCCTCAGATGCAGAGTTCTGACATCTGGGATTTTTGAGACACGATTCCAA
GTGGACAAAGTAAACTTCCACATGTTTGATGTTGGTGGCCAGAGGGATGAGAGGAGAAAA
TGGATCCAGTGCTTTAACGATGTCACAGCTATCATTTACGTCGCAGCCTGCAGTAGCTAC
AACATGGTGATTCGAGAAGATAACAACACCAACAGGCTGAGAGAGTCCCTGGATCTTTTT
GAAAGCATCTGGAACAACAGGTGGTTACGGACCATTTCTATCATCTTGTTCTTGAACAAA
CAAGATATGCTGGCAGAAAAAGTCTTGGCAGGGAAATCAAAAATTGAAGACTATTTCCCA
GAATATGCAAATTATACTGTTCCTGAAGACGCAACACCAGATGCAGGAGAAGATCCCAAA
GTTACAAGAGCCAAGTTCTTTATCCGGGACCTGTTTTTGAGGATCAGCACGGCCACCGGT
GACGGCAAACATTACTGCTACCCGCACTTCACCTGCGCCGTGGACACAGAGAACATCCGC
AGGGTGTTCAACGACTGCCGCGACATCATCCAGCGGATGCACCTCAAGCAGTATGAGCTC
TTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 381 |
| Molecular Weight
| 44308.1 |
| Theoretical pI
| 6.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Guanine nucleotide-binding protein G(olf) subunit alpha
MGCLGGNSKTTEDQGVDEKERREANKKIEKQLQKERLAYKATHRLLLLGAGESGKSTIVK
QMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKS
IAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPT
DQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSY
NMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFP
EYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIR
RVFNDCRDIIQRMHLKQYELL
|
| External Links |
|---|
| GenBank ID Protein
| 20147679 |
| UniProtKB/Swiss-Prot ID
| P38405 |
| UniProtKB/Swiss-Prot Entry Name
| GNAL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF493893 |
| GeneCard ID
| GNAL |
| GenAtlas ID
| GNAL |
| HGNC ID
| HGNC:4388 |
| References |
|---|
| General References
| - Zigman JM, Westermark GT, LaMendola J, Boel E, Steiner DF: Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system. Endocrinology. 1993 Dec;133(6):2508-14. [PubMed:8243272 ]
|
