Hmdb loader
Identification
HMDB Protein ID HMDBP11498
Secondary Accession Numbers
  • 17852
Name Engulfment and cell motility protein 3
Synonyms Not Available
Gene Name ELMO3
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1
Pathways Not Available
Reactions Not Available
GO Classification
Component
cytoskeleton
organelle
non-membrane-bounded organelle
intracellular non-membrane-bounded organelle
Process
cellular process
cellular membrane organization
membrane invagination
endocytosis
phagocytosis
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 16q22.1
SNPs ELMO3
Gene Sequence
>2322 bp
ATGGCCAGGAGCAGCAGTCTGGGCCGCGAGTGCGGGACACCGAGGTCAGGTCTCGGAAAG
GGAGGACCTCCTCGTCCCCAGGGGCCCCAGGCCAGGTGCACCCTTGGCCGCAGGTGCACG
GTCTCCGGAAAGTGCAGGCGCCCACGTCCCAGCTGGACCATGGCGCCTCCGCGGAACGTG
GTGAAGATTGCCATCAAGATGCGTGACGCCATCCCGCAGCTCATCCAGCTGGACCAGGCG
AAGCCCCTGGCCGCTGTGCTGAAGGAGGTGTGCGACGCGTGGAGCCTGACGCACTCTGAG
CGTTACGCCCTGCAGTTTGCGGATGGGCACCGGAGATACATCACCGAGAATAACCGCGCG
GAGATCAAGAATGGCAGCATCCTGTGCCTCAGCACGGCCCCAGACCTTGAGGCTGAGCAG
CTCTTGGGTGGGCTGCAGAGTAACAGTCCTGAAGGGCGCCGGGAAGCCCTGAGGCGCCTT
GTTCCGCTGGCCTCGGACATGATCTTTGCCAGGGAGGTCATCAGCCGTAATGGGCTCCAG
ATACTAGGCACCATCATTGAAGATGGGGACGACCTAGGAGAGGTGCTGGCCCTCAGCCTG
AGGGCCTTCTCAGAGCTCATGGAGCACGGCGTGGTGTCCTGGGAGACTCTGAGCATCCCC
TTTGTGAGGAAGGTGGTGTGCTACGTGAACATGAACCTCATGGATGCCTCCGTGCCTCCC
CTGGCCCTTGGGCTGCTGGAGAGTGTGACCTTGAGCAGCCCAGCCCTGGGCCAGCTGGTC
AAGAGCGAGGTGCCCCTGGATAGGCTGCTGGTGCACCTACAGGTGATGAACCAGCAGCTG
CAAACCAAGGCCATGGCCCTGCTGACAGCCTTGCTGCAGGGGGCCAGCCCTGTGGAACGC
AAGCACATGCTTGACTATCTTTGGCAGAGGAACCTTCGCCAGTTCATCTATAAGAACATC
ATCCACAGTGCAGCACCAATGGGCGACGAGATGGCTCATCACCTGTACGTACTGCAGGCT
CTCATGCTGGGGCTGCTGGAGCCGCGCATGCGGACGCCCCTGGACCCCTACAGCCAGGAG
CAGCGGGAGCAGCTGCAGGTCCTACGCCAGGCTGCCTTCGAGGTGGAGGGGGAGTCCTCG
GGTGCCGGGCTAAGTGCTGACCGTCGCCGTTCCCTCTGTGCCCGAGAGTTCCGCAAACTG
GGCTTTTCTAACAGCAACCCAGCACAGGACCTGGAGCGCGTGCCCCCCGGTCTGCTGGCC
CTGGACAACATGTTGTACTTCTCCAGAAACGCGCCCAGCGCGTACAGCCGGTTTGTGTTG
GAGAACAGCAGCCGCGAGGACAAGCACGAGTGCCCCTTTGCCCGGGGCAGCATCCAGCTG
ACGGTGCTGCTGTGTGAGCTGCTCCGTGTTGGGGAGCCCTGCTCTGAGACAGCCCAGGAC
TTCTCACCCATGTTCTTCGGCCAAGACCAGAGCTTCCACGAGCTCTTCTGTGTGGGCATC
CAGCTGTTGAATAAGACCTGGAAGGAGATGCGGGCTACACAGGAGGACTTCGACAAGGTC
ATGCAGGTGGTGCGGGAGCAGCTGGCCCGCACTCTGGCCCTGAAGCCCACTTCCCTGGAG
CTCTTCCGAACCAAGGTGAATGCGCTCACTTATGGGGAGGTGCTGCGGCTGCGGCAGACT
GAACGGCTGCACCAGGAGGGCACACTGGCTCCCCCTATACTGGAGCTGCGGGAGAAGCTG
AAGCCAGAGCTCATGGGCCTGATCCGCCAGCAGCGCTTGCTCCGCCTCTGTGAGGGGACG
CTCTTCCGCAAGATCAGCAGCCGGCGGCGCCAGGATAAGCTGTGGTTCTGCTGCCTGTCC
CCCAACCACAAGCTGCTGCAGTACGGAGACATGGAGGAGGGCGCCAGCCCGCCTACCCTG
GAGAGTCTGCCCGAGCAACTCCCTGTGGCCGACATGAGGGCACTCCTGACAGGCAAGGAC
TGCCCCCATGTCCGGGAGAAGGGCTCCGGGAAGCAGAACAAGGACCTCTATGAGTTGGCC
TTCTCAATCAGCTATGACCGTGGGGAGGAGGAAGCGTACCTCAACTTCATTGCCCCCTCC
AAGCGGGAGTTCTACCTGTGGACAGATGGGCTCAGTGCCTTGCTGGGCAGTCCCATGGGC
AGCGAGCAGACACGGCTGGACCTGGAGCAGCTGCTGACCATGGAGACCAAGCTGCGTCTG
CTGGAGCTGGAGAACGTGCCCATCCCCGAGCGGCCACCCCCTGTGCCCCCACCCCCCACC
AACTTCAACTTCTGCTATGACTGCAGCATCGCTGAACCTTGA
Protein Properties
Number of Residues 720
Molecular Weight 81466.2
Theoretical pI 6.23
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Engulfment and cell motility protein 3
MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRY
ITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREV
ISRNGLQILGTIIEDGDDLGEVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNL
MDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQ
GASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTP
LDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFSNSNPAQDLER
VPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEP
CSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLA
LKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRL
LRLCEGTLFRKISSRRRQDKLWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMR
ALLTGKDCPHVREKGSGKQNKDLYELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSA
LLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP
GenBank ID Protein 87298935
UniProtKB/Swiss-Prot ID Q96BJ8
UniProtKB/Swiss-Prot Entry Name ELMO3_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID ELMO3
GenAtlas ID ELMO3
HGNC ID HGNC:17289
References
General References
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