Hmdb loader
Identification
HMDB Protein ID HMDBP11005
Secondary Accession Numbers
  • 17329
Name Long-chain-fatty-acid--CoA ligase ACSBG1
Synonyms
  1. Acyl-CoA synthetase bubblegum family member 1
  2. Lipodisin
  3. hBG1
  4. hsBG
  5. hsBGM
  6. Lipidosin
Gene Name ACSBG1
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
Pathways
  • Adipocytokine signaling pathway
  • fatty acid metabolism
  • PPAR signaling pathway
Reactions
Adenosine triphosphate + a long-chain fatty acid + Coenzyme A → Adenosine monophosphate + Pyrophosphate + an acyl-CoA details
Adenosine triphosphate + Palmitic acid + Coenzyme A → Adenosine monophosphate + Palmityl-CoA + Pyrophosphate details
GO Classification
Biological Process
myelination
ovarian follicle atresia
very long-chain fatty acid metabolic process
response to glucocorticoid stimulus
Cellular Component
cytoplasm
endoplasmic reticulum
cytoplasmic membrane-bounded vesicle
Function
catalytic activity
Molecular Function
ATP binding
long-chain fatty acid-CoA ligase activity
very long-chain fatty acid-CoA ligase activity
Process
metabolic process
Cellular Location
  1. Cytoplasm
  2. Cytoplasmic vesicle
  3. Microsome
  4. Endoplasmic reticulum
Gene Properties
Chromosome Location 15
Locus 15q23-q24
SNPs ACSBG1
Gene Sequence
>2175 bp
ATGCCACGCAATTCTGGAGCTGGATACGGCTGCCCACACGGGGACCCCAGCATGCTGGAC
AGCAGAGAGACCCCACAGGAGAGCCGGCAGGACATGATTGTGAGGACCACCCAAGAAAAA
TTGAAAACCAGCTCACTGACTGACAGGCAGCCACTCTCCAAAGAGTCCCTGAACCATGCT
CTCGAGCTCTCAGTGCCAGAGAAGGTGAATAATGCCCAGTGGGATGCTCCAGAGGAGGCG
CTGTGGACGACTCGGGCCGATGGGCGGGTGCGCCTGCGCATAGACCCCAGCTGCCCACAG
CTTCCCTACACTGTGCATCGGATGTTCTACGAGGCCCTGGATAAGTATGGGGACCTCATC
GCTTTGGGCTTCAAGCGCCAGGACAAGTGGGAACACATCTCCTACTCCCAATACTACCTG
CTCGCCCGCAGAGCCGCCAAGGGCTTCCTGAAGCTCGGCCTGAAGCAGGCCCACAGTGTG
GCCATCCTCGGCTTCAACTCCCCGGAGTGGTTCTTCTCGGCAGTGGGCACAGTATTTGCA
GGTGGCATCGTCACTGGCATCTACACCACCAGCTCCCCAGAGGCCTGCCAGTACATCGCT
TATGACTGCTGCGCCAATGTCATCATGGTCGACACGCAGAAGCAGCTGGAAAAGATCCTG
AAGATCTGGAAACAGTTGCCACATCTAAAGGCAGTCGTGATATATAAAGAACCTCCTCCA
AACAAGATGGCCAATGTGTACACGATGGAGGAATTCATGGAGCTGGGGAATGAAGTGCCT
GAGGAAGCCCTGGACGCCATCATTGACACCCAGCAGCCCAACCAGTGCTGTGTGCTAGTC
TACACTTCCGGCACCACTGGGAACCCCAAGGGCGTGATGCTGAGTCAAGACAATATCACG
TGGACGGCACGGTACGGCAGCCAGGCCGGTGACATCCGGCCGGCAGAAGTCCAGCAGGAG
GTGGTAGTCAGCTACCTGCCCCTCAGCCATATTGCCGCCCAGATCTACGACCTGTGGACA
GGCATCCAGTGGGGGGCCCAGGTTTGCTTTGCCGAACCCGACGCCCTGAAGGGGAGCCTG
GTGAACACGCTGCGGGAGGTGGAGCCCACATCACACATGGGGGTGCCCCGGGTATGGGAG
AAGATCATGGAGCGCATCCAGGAGGTGGCGGCTCAGTCTGGCTTCATCCGGCGAAAGATG
CTGCTGTGGGCCATGTCGGTGACCTTGGAGCAGAACCTCACCTGCCCCGGCAGCGACCTG
AAGCCCTTCACAACCAGACTGGCAGATTACCTGGTGCTAGCCAAGGTTCGCCAGGCACTG
GGATTTGCCAAGTGTCAAAAGAACTTCTATGGAGCGGCCCCCATGATGGCAGAGACACAG
CACTTCTTCCTGGGTCTCAACATCCGCTTGTATGCGGGCTACGGCCTCAGTGAGACCTCA
GGCCCCCACTTCATGTCCAGTCCCTACAACTACCGGCTGTACAGCTCAGGCAAGTTGGTG
CCCGGCTGTCGGGTGAAGCTGGTGAACCAGGACGCAGAGGGCATTGGCGAGATCTGCCTG
TGGGGCCGCACCATATTCATGGGCTACCTGAACATGGAGGACAAGACTTGTGAGGCCATC
GACGAGGAAGGCTGGCTGCACACGGGTGATGCTGGCCGCCTGGACGCCGATGGCTTCCTC
TACATCACTGGGCGCCTCAAAGAATTAATCATCACAGCTGGTGGGGAGAATGTGCCCCCT
GTGCCCATCGAGGAGGCCGTGAAGATGGAGCTGCCCATCATCAGCAACGCCATGCTCATT
GGGGACCAGAGGAAGTTCCTGTCCATGCTGCTCACCTTGAAGTGCACTCTGGACCCAGAC
ACCTCTGACCAGACTGATAATCTGACTGAACAAGCTATGGAGTTCTGCCAGAGGGTGGGC
AGCAGAGCCACCACAGTGTCCGAGATCATAGAGAAGAAGGATGAGGCCGTGTACCAGGCC
ATCGAAGAGGGGATCCGGAGGGTCAACATGAACGCGGCGGCCCGGCCCTACCACATCCAG
AAGTGGGCCATTCTCGAGAGAGACTTCTCCATTTCGGGTGGAGAGTTGGGTCCCACGATG
AAACTGAAACGGCTCACAGTTTTGGAGAAGTACAAAGGTATCATTGACTCCTTTTACCAA
GAGCAAAAAATGTAA
Protein Properties
Number of Residues 724
Molecular Weight 80878.065
Theoretical pI 5.92
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Long-chain-fatty-acid--CoA ligase ACSBG1
MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHA
LELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLI
ALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFA
GGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPP
NKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNIT
WTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSL
VNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDL
KPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETS
GPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAI
DEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLI
GDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQA
IEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQ
EQKM
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96GR2
UniProtKB/Swiss-Prot Entry Name ACBG1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF179481
GeneCard ID ACSBG1
GenAtlas ID ACSBG1
HGNC ID HGNC:29567
References
General References
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