Hmdb loader
Identification
HMDB Protein ID HMDBP10976
Secondary Accession Numbers
  • 17290
Name Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Synonyms
  1. Centaurin-beta-2
  2. Cnt-b2
Gene Name ACAP2
Protein Type Unknown
Biological Properties
General Function Involved in ARF GTPase activator activity
Specific Function GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6)
Pathways Not Available
Reactions Not Available
GO Classification
Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
enzyme regulator activity
arf gtpase activator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of cellular metabolic process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
regulation of nucleotide metabolic process
regulation of nucleotide catabolic process
regulation of purine nucleotide catabolic process
regulation of gtp catabolic process
regulation of gtpase activity
regulation of ras gtpase activity
regulation of arf gtpase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:3
Locus 3q29
SNPs ACAP2
Gene Sequence
>2337 bp
ATGAAGATGACTGGGGATTTCGAGGAGTGTCTGAAGGACTCGCCCCGCTTCAGGGCAGCT
TTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAA
CTTGGGATTGCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATG
AATGGGATTCGAGACCTGGCCCAGTATTCTAGTAATGATGCTGTCGTTGAGACAAGTTTG
ACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATCCTGTTGCCAAAC
TCAGAGATCAATTTAAGGCACAGCTTCAGTAACTTTGTTAAAGAAGATCTTAGAAAATTC
AAAGATGCCAAGAAGCAATTTGAAAAAGTCAGTGAAGAAAAAGAAAATGCGTTAGTAAAA
AATGCCCAAGTACAAAGAAACAAACAACATGAAGTTGAAGAAGCCACCAACATTCTGACA
GCAACAAGAAAATGTTTCCGACACATAGCCCTCGATTATGTGCTTCAGATTAATGTTCTT
CAATCAAAAAGGAGATCAGAAATCCTAAAATCAATGTTGTCATTTATGTATGCCCATTTG
GCCTTCTTTCATCAAGGATATGATCTGTTTAGTGAACTTGGACCCTACATGAAGGATCTT
GGTGCACAGTTGGATCGACTGGTTGGGGATGCAGCAAAGGAGAAAAGAGAAATGGAGCAA
AAACATTCCACCATTCAACAAAAGGATTTCTCCAGGGATGATTCTAAATTAAAATATAAC
GTAGATGCTGCAAATGGCATAGTTATGGAAGGATATCTGTTCAAACGAGCCAGCAATGCC
TTCAAAACTTGGAACAGGCGCTGGTTTTCAATACAAAATAATCAGGTGGTTTACCAGAAA
AAATTTAAGGATAATCCGACTGTGGTAGTTGAAGACCTCAGGCTTTGCACAGTGAAACAT
TGTGAAGACATAGAGCGACGATTCTGCTTTGAGGTGGTCTCGCCAACAAAAAGTTGTATG
CTCCAGGCAGATTCCGAAAAGCTGCGCCAGGCATGGATTAAGGCTGTTCAGACCAGTATT
GCTACTGCTTATAGAGAGAAGGGTGATGAATCAGAGAAGCTGGATAAGAAATCATCTCCA
TCCACAGGAAGCCTAGATTCTGGAAATGAGTCCAAAGAGAAATTATTGAAAGGAGAAAGT
GCGCTTCAGCGGGTCCAGTGTATCCCTGGCAATGCCAGCTGTTGTGACTGTGGCCTGGCA
GATCCACGGTGGGCCAGCATCAACCTGGGCATCACCTTGTGTATCGAGTGCTCCGGAATT
CACCGGAGCCTTGGGGTTCATTTTTCAAAAGTACGATCTTTAACTTTAGACACCTGGGAG
CCAGAACTTTTAAAGCTTATGTGTGAGTTGGGGAATGATGTTATAAATCGAGTTTATGAA
GCTAATGTGGAAAAAATGGGAATAAAGAAACCCCAACCAGGACAAAGACAGGAGAAGGAG
GCATATATCAGAGCAAAATATGTGGAGAGGAAATTTGTGGATAAATATTCTATATCATTA
TCACCTCCTGAGCAGCAAAAAAAGTTTGTCTCTAAAAGTTCTGAAGAAAAGAGGCTGAGC
ATTTCTAAATTTGGGCCAGGGGACCAAGTCAGAGCATCTGCCCAAAGTTCAGTCAGAAGT
AATGACAGTGGAATTCAGCAGAGCTCTGATGATGGAAGAGAATCTTTACCCTCCACGGTG
TCAGCCAATAGTTTATATGAGCCTGAAGGAGAAAGGCAAGATTCTTCTATGTTTCTTGAC
TCGAAACATCTTAATCCAGGACTTCAGCTTTATAGGGCGTCATATGAAAAAAACCTTCCT
AAAATGGCTGAGGCTTTGGCTCATGGTGCAGACGTGAACTGGGCCAATTCAGAGGAAAAC
AAAGCGACACCACTTATTCAGGCTGTATTAGGGGGCTCTTTGGTGACGTGTGAGTTCCTC
CTACAGAATGGTGCTAATGTCAACCAAAGAGATGTCCAAGGGCGGGGACCATTGCACCAT
GCCACCGTCTTAGGGCACACAGGGCAGGTATGTTTATTCCTAAAACGAGGTGCCAATCAA
CATGCCACTGATGAAGAAGGGAAAGACCCTTTGAGCATAGCTGTGGAAGCAGCCAATGCT
GATATAGTCACCTTGTTACGTTTAGCAAGAATGAATGAAGAGATGCGGGAATCAGAAGGA
CTTTATGGACAGCCAGGTGATGAAACTTATCAGGACATATTTCGTGATTTTTCCCAAATG
GCATCCAATAATCCAGAGAAACTAAATCGTTTCCAGCAAGATTCACAGAAATTCTGA
Protein Properties
Number of Residues 778
Molecular Weight 88027.9
Theoretical pI 6.78
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFM
NGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKF
KDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVL
QSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQ
KHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQK
KFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSI
ATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLA
DPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYE
ANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLS
ISKFGPGDQVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLD
SKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFL
LQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANA
DIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF
GenBank ID Protein 4688902
UniProtKB/Swiss-Prot ID Q15057
UniProtKB/Swiss-Prot Entry Name ACAP2_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ238248
GeneCard ID ACAP2
GenAtlas ID ACAP2
HGNC ID HGNC:16469
References
General References
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  3. Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol. 2005 Jan;23(1):94-101. Epub 2004 Dec 12. [PubMed:15592455 ]
  4. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  5. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
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