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Showing Protein Minor histocompatibility protein HA-1 (HMDBP10953)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 9288 metabolites
Identification
HMDB Protein ID HMDBP10953
Secondary Accession Numbers
  • 17266
Name Minor histocompatibility protein HA-1
Synonyms
  1. Minor histocompatibility antigen HA-1
  2. mHag HA-1
Gene Name HMHA1
Protein Type Unknown
Biological Properties
General Function Involved in intracellular signaling pathway
Specific Function Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA- identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor- cytotoxic T lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signaling pathway
signaling
signaling pathway
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.3
SNPs HMHA1
Gene Sequence 
>3411 bp
ATGTTCTCCAGGAAGAAACGAGAGCTCATGAAAACCCCTTCCATCTCGAAAAAGAACCGC
GCGGGAAGCCCCAGCCCGCAGCCCTCGGGGGAGCTGCCCAGGAAGGATGGGGCTGACGCG
GTGTTCCCCGGACCAAGCCTGGAGCCGCCCGCTGGGTCCTCCGGCGTCAAGGCCACAGGG
ACCCTCAAGCGGCCCACCAGCCTGAGCCGCCACGCCAGCGCGGCTGGCTTCCCCCTGTCG
GGTGCTGCCTCCTGGACACTGGGCCGGAGCCACCGGAGCCCACTGACAGCCGCCAGCCCG
GGCGAGCTGCCCACCGAGGGTGCCGGCCCGGACGTCGTCGAGGACATCTCCCATCTGCTG
GCGGACGTGGCCCGCTTCGCTGAGGGCCTTGAGAAACTTAAGGAGTGTGTGTTGCGTGAC
GACCTCCTTGAGGCCCGCCGCCCGCGGGCCCACGAGTGCCTGGGTGAGGCTCTGCGTGTC
ATGCATCAGATCATCTCCAAGTACCCGCTGCTGAACACCGTGGAGACGCTCACCGCAGCC
GGCACCCTCATTGCCAAGGTCAAAGCCTTCCATTATGAGAGCAACAATGATCTGGAGAAA
CAGGAGTTCGAGAAGGCCCTGGAGACGATTGCTGTGGCCTTCAGTAGCACAGTGTCCGAG
TTCCTCATGGGTGAAGTGGACAGCAGCACCCTCCTAGCAGTGCCTCCTGGGGACTCGAGC
CAGTCCATGGAAAGCCTGTATGGACCGGGCAGTGAGGGCACGCCTCCCAGCCTGGAAGAC
TGTGACGCCGGCTGCCTGCCCGCCGAGGAGGTGGACGTGCTGCTACAGCGCTGTGAGGGG
GGCGTGGATGCCGCACTGCTGTATGCCAAGAACATGGCCAAGTACATGAAGGACCTCATC
AGCTACCTGGAGAAGCGGACGACGCTGGAGATGGAGTTTGCCAAGGGCCTGCAGAAGATC
GCTCACAACTGCAGACAGAGCGTCATGCAGGAGCCCCACATGCCGCTCCTGTCCATCTAC
TCGCTGGCCCTGGAGCAGGACCTGGAGTTCGGCCACAGCATGGTGCAGGCGGTGGGCACC
TTGCAGACCCAGACCTTCATGCAGCCCCTGACCCTGCGGCGGCTTGAACACGAGAAGCGC
AGGAAGGAGATCAAGGAGGCCTGGCACCGTGCCCAGAGGAAGCTGCAAGAGGCGGAGTCC
AACCTGCGCAAGGCCAAGCAGGGTTACGTGCAGCGCTGCGAGGACCACGACAAGGCTCGC
TTCCTCGTGGCCAAGGCGGAGGAGGAGCAGGCTGGCAGCGCGCCGGGAGCAGGCAGCACG
GCCACCAAGACCCTGGACAAGCGGCGGCGGCTGGAGGAGGAGGCCAAGAACAAGGCGGAG
GAAGCTATGGCCACCTACCGCACCTGCGTGGCCGACGCGAAGACGCAGAAGCAGGAGCTG
GAGGATACCAAGGTGACGGCGCTGCGGCAGATCCAGGAGGTCATCCGGCAGAGCGACCAA
ACCATCAAGTCGGCCACGATCTCCTACTACCAGATGATGCATATGCAGACGGCGCCGCTG
CCCGTGCACTTCCAGATGCTGTGTGAGAGCAGCAAGCTGTATGACCCAGGCCAGCAGTAC
GCCTCCCACGTGCGCCAGCTGCAGCGGGACCAGGAGCCCGATGTGCACTACGACTTTGAG
CCCCACGTCTCCGCCAACGCCTGGTCCCCCGTCATGCGTGCCCGGAAGAGCAGCTTCAAC
GTGAGTGATGTGGCGCGGCCGGAGGCTGCCGGGAGCCCCCCAGAAGAAGGCGGGTGCACT
GAGGGCACACCTGCCAAGGACCACAGGGCCGGGCGAGGACACCAGGTTCACAAGTCATGG
CCGCTCTCGATCTCAGACTCGGACAGTGGGCTGGACCCCGGCCCTGGCGCAGGGGACTTT
AAGAAGTTCGAGCGGACGTCATCCAGTGGTACCATGTCGTCCACGGAGGAGCTGGTGGAC
CCAGACGGTGGAGCCGGGGCTTCAGCCTTTGAGCAGGCTGACCTCAACGGCATGACCCCC
GAGCTGCCGGTGGCCGTGCCCAGTGGACCGTTCCGCCACGAGGGGCTGTCCAAGGCGGCC
CGTACTCACCGGCTCCGGAAGCTCCGCACGCCCGCCAAGTGCCGCGAGTGCAACAGCTAC
GTCTACTTCCAGGGTGCTGAGTGTGAAGAGTGCTGCCTGGCCTGCCACAAGAAATGTCTG
GAGACGCTGGCCATACAGTGCGGGCACAAGAAGCTGCAAGGCCGCCTGCAGCTGTTCGGC
CAGGACTTCAGCCACGCGGCCCGCAGCGCCCCCGACGGCGTGCCCTTCATCGTCAAGAAG
TGCGTCTGCGAGATCGAGCGGCGGGCGCTGCGCACCAAGGGCATCTACCGGGTCAATGGG
GTAAAGACACGCGTGGAGAAGCTGTGCCAGGCCTTCGAGAACGGCAAGGAGCTGGTCGAG
CTGTCGCAGGCCTCGCCCCACGACATCAGCAACGTCCTCAAGCTCTACCTGCGTCAGCTT
CCCGAGCCGCTCATCTCCTTCCGCCTCTACCACGAGCTCGTAGGGCTGGCCAAGGACAGC
CTGAAGGCAGAGGCCGAGGCCAAGGCGGCGTCCCGGGGCCGGCAGGACGGCTCGGAGAGC
GAGGCAGTGGCGGTGGCCCTGGCAGGTCGGCTGCGGGAGCTCCTGCGGGACCTGCCGCCT
GAGAACCGGGCCTCGCTGCAGTACCTGCTGCGTCACCTACGCAGGATCGTGGAGGTGGAG
CAGGACAACAAGATGACCCCCGGGAACCTGGGCATCGTGTTCGGGCCCACGCTGCTTCGG
CCACGGCCCACCGAGGCCACCGTGTCCCTCTCCTCCCTGGTGGATTATCCCCATCAGGCC
CGCGTCATCGAGACTCTCATCGTCCACTACGGCCTGGTCTTCGAGGAGGAGCCGGAGGAG
ACCCCCGGGGGCCAGGACGAGTCATCCAACCAGCGAGCTGAGGTAGTCGTCCAGGTGCCG
TACCTGGAGGCGGGCGAGGCGGTGGTCTACCCGCTGCAGGAGGCGGCGGCGGACGGGTGC
AGAGAATCCCGAGTTGTGTCCAACGATTCGGACTCGGACCTAGAGGAGGCCTCCGAGCTG
CTGTCCTCATCGGAGGCCAGTGCCCTGGGCCACCTCAGCTTCCTGGAGCAGCAGCAGAGC
GAGGCCAGCCTAGAGGTGGCTTCTGGCAGCCACAGCGGCAGTGAGGAGCAGCTGGAGGCC
ACAGCCCGGGAGGACGGGGACGGGGACGAGGACGGCCCGGCCCAGCAGCTCTCAGGATTC
AACACCAACCAGTCCAACAACGTGCTGCAGGCCCCACTGCCCCCCATGAGGCTCCGTGGC
GGGCGGATGACACTGGGCTCCTGCAGGGAAAGGCAGCCGGAATTCGTGTGA
Protein Properties
Number of Residues 1136
Molecular Weight 124613.1
Theoretical pI 6.0
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Minor histocompatibility protein HA-1
MFSRKKRELMKTPSISKKNRAGSPSPQPSGELPRKDGADAVFPGPSLEPPAGSSGVKATG
TLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGELPTEGAGPDVVEDISHLL
ADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVETLTAA
GTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSSTLLAVPPGDSS
QSMESLYGPGSEGTPPSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLI
SYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQDLEFGHSMVQAVGT
LQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAKQGYVQRCEDHDKAR
FLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQEL
EDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQY
ASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCT
EGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEELVD
PDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSY
VYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKK
CVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQL
PEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPP
ENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQA
RVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGC
RESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEA
TAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPPMRLRGGRMTLGSCRERQPEFV
GenBank ID Protein 47834348
UniProtKB/Swiss-Prot ID Q92619
UniProtKB/Swiss-Prot Entry Name HMHA1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_012292.2
GeneCard ID HMHA1
GenAtlas ID HMHA1
HGNC ID HGNC:17102
References
General References
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