Hmdb loader
Identification
HMDB Protein ID HMDBP10756
Secondary Accession Numbers
  • 17023
Name Nucleolar and coiled-body phosphoprotein 1
Synonyms
  1. 140 kDa nucleolar phosphoprotein
  2. HCV NS5A-transactivated protein 13
  3. Hepatitis C virus NS5A-transactivated protein 13
  4. Nopp140
  5. Nucleolar 130 kDa protein
  6. Nucleolar phosphoprotein p130
Gene Name NOLC1
Protein Type Unknown
Biological Properties
General Function Translation, ribosomal structure and biogenesis
Specific Function Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. nucleolus
Gene Properties
Chromosome Location Chromosome:1
Locus 10q24.32
SNPs NOLC1
Gene Sequence
>2100 bp
ATGGCGGACGCCGGCATTCGCCGCGTGGTTCCCAGCGACCTGTATCCCCTCGTGCTCGGC
TTCCTGCGCGATAACCAACTCTCAGAGGTGGCCAATAAGTTCGCCAAAGCGACAGGAGCT
ACACAGCAGGATGCCAATGCCTCTTCCCTCTTAGACATCTATAGCTTCTGGCTCAAGTCT
GCCAAGGTCCCAGAGCGAAAGTTACAGGCAAATGGACCAGTGGCTAAGAAAGCTAAGAAG
AAGGCCTCATCCAGTGACAGTGAGGACAGCAGCGAGGAGGAGGAGGAAGTTCAAGGGCCT
CCAGCAAAGAAGGCTGCTGTACCTGCCAAGCGAGTCGGTCTGCCTCCTGGGAAGGCTGCA
GCCAAAGCATCAGAGAGTAGCAGCAGTGAAGAGTCCAGTGATGATGATGATGAGGAGGAC
CAAAAGAAACAGCCTGTCCAGAAGGGAGTTAAGCCCCAAGCCAAGGCAGCCAAAGCTCCT
CCTAAGAAGGCCAAGAGCTCTGATTCTGATTCTGACTCAAGCTCCGAGGATGAGCCACCA
AAGAACCAGAAGCCAAAGATAACACCTGTGACAGTTAAAGCTCAGACTAAAGCCCCTCCC
AAACCAGCTCGAGCAGCACCTAAAATAGCCAATGGTAAAGCAGCCAGTAGCAGCAGTAGC
AGCAGCAGCAGCAGTAGCAGTGATGACTCAGAGGAGGAGAAGGCAGCAGCCACCCCCAAG
AAGACTGTACCTAAAAAGCAAGTTGTGGCCAAGGCCCCAGTGAAAGCAGCTACCACCCCT
ACCCGGAAGAGTTCTAGCAGTGAGGATTCCTCCAGTGACGAGGAAGAGGAGCAAAAAAAA
CCCATGAAAAATAAACCAGGTCCCTACAGTTCAGTCCCCCCGCCTTCTGCTCCCCCACCA
AAGAAGTCTCTGGGAACCCAGCCTCCCAAGAAGGCTGTGGAGAAGCAGCAGCCTGTGGAA
AGCAGTGAAGACAGCAGTGATGAGTCTGATTCAAGTTCTGAAGAAGAGAAGAAACCCCCA
ACTAAGGCAGTAGTCTCTAAAGCAACCACTAAACCACCTCCAGCAAAGAAAGCAGCAGAG
AGCTCTTCAGACAGCTCAGACTCTGACAGCTCTGAGGATGATGAAGCTCCTTCTAAGCCA
GCTGGTACCACCAAGAATTCTTCAAATAAGCCAGCTGTCACCACCAAGTCACCTGCAGTG
AAGCCAGCTGCAGCCCCCAAGCAACCTGTGGGCGGTGGCCAGAAGCTTCTGACGAGAAAG
GCTGACAGCAGCTCCAGTGAGGAAGAGAGCAGCTCCAGTGAGGAGGAGAAGACAAAGAAG
ATGGTGGCCACCACTAAGCCCAAGGCGACTGCCAAAGCAGCTCTATCTCTGCCTGCCAAG
CAGGCTCCTCAGGGTAGTAGGGACAGCAGCTCTGATTCAGACAGCTCCAGCAGTGAGGAG
GAGGAAGAGAAGACATCTAAGTCTGCAGTTAAGAAGAAGCCACAGAAGGTAGCAGGAGGT
GCAGCCCCTTCCAAGCCAGCCTCTGCAAAGAAAGGAAAGGCTGAGAGCAGCAACAGTTCT
TCTTCTGATGACTCCAGTGAGGAAGAGGAAGAGAAGCTCAAGGGCAAGGGCTCTCCAAGA
CCACAAGCCCCCAAGGCCAATGGCACCTCTGCACTGACTGCCCAGAATGGAAAAGCAGCT
AAGAACAGTGAGGAGGAGGAAGAAGAAAAGAAAAAGGCGGCAGTGGTAGTTTCCAAATCA
GGTTCATTAAAGAAGCGGAAGCAGAATGAGGCTGCCAAGGAGGCAGAGACTCCTCAGGCC
AAGAAGATAAAGCTTCAGACCCCTAACACATTTCCAAAAAGGAAGAAAGGAGAAAAAAGG
GCATCATCCCCATTCCGAAGGGTCAGGGAGGAGGAAATTGAGGTGGATTCACGAGTTGCG
GACAACTCCTTTGATGCCAAGCGAGGTGCAGCCGGAGACTGGGGAGAGCGAGCCAATCAG
GTTTTGAAGTTCACCAAAGGCAAGTCCTTTCGGCATGAGAAAACCAAGAAGAAGCGGGGC
AGCTACCGGGGAGGCTCAATCTCTGTCCAGGTCAATTCTATTAAGTTTGACAGCGAGTGA
Protein Properties
Number of Residues 699
Molecular Weight 73602.5
Theoretical pI 10.23
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Nucleolar and coiled-body phosphoprotein 1
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS
AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA
AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP
KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK
KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP
KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE
SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK
ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE
EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR
PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA
KKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQ
VLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKFDSE
GenBank ID Protein 55665422
UniProtKB/Swiss-Prot ID Q14978
UniProtKB/Swiss-Prot Entry Name NOLC1_HUMAN
PDB IDs Not Available
GenBank Gene ID AL500527
GeneCard ID NOLC1
GenAtlas ID NOLC1
HGNC ID HGNC:15608
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP: Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9. [PubMed:15302935 ]
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  7. Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
  8. Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6. [PubMed:18187866 ]
  9. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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  12. Molina H, Horn DM, Tang N, Mathivanan S, Pandey A: Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2199-204. Epub 2007 Feb 7. [PubMed:17287340 ]
  13. Tang LY, Deng N, Wang LS, Dai J, Wang ZL, Jiang XS, Li SJ, Li L, Sheng QH, Wu DQ, Li L, Zeng R: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. Mol Cell Proteomics. 2007 Nov;6(11):1952-67. Epub 2007 Aug 12. [PubMed:17693683 ]
  14. Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. Proteomics. 2008 Apr;8(7):1346-61. doi: 10.1002/pmic.200700884. [PubMed:18318008 ]
  15. Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. Anal Chem. 2004 May 15;76(10):2763-72. [PubMed:15144186 ]
  16. Wang B, Malik R, Nigg EA, Korner R: Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. Anal Chem. 2008 Dec 15;80(24):9526-33. doi: 10.1021/ac801708p. [PubMed:19007248 ]
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  18. Pai CY, Chen HK, Sheu HL, Yeh NH: Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. J Cell Sci. 1995 May;108 ( Pt 5):1911-20. [PubMed:7657714 ]
  19. Pai CY, Yeh NH: Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130. Biochem Biophys Res Commun. 1996 Apr 25;221(3):581-7. [PubMed:8630004 ]
  20. Chen HK, Yeh NH: The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. Biochem Biophys Res Commun. 1997 Jan 13;230(2):370-5. [PubMed:9016786 ]
  21. Chen HK, Pai CY, Huang JY, Yeh NH: Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization. Mol Cell Biol. 1999 Dec;19(12):8536-46. [PubMed:10567578 ]