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Showing Protein Ubiquitin carboxyl-terminal hydrolase 17 (HMDBP10670)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP10670
Secondary Accession Numbers
  • 16928
Name Ubiquitin carboxyl-terminal hydrolase 17
Synonyms
  1. Deubiquitinating enzyme 17
  2. Ubiquitin thiolesterase 17
  3. Ubiquitin-specific-processing protease 17
Gene Name USP17A
Protein Type Enzyme
Biological Properties
General Function Involved in ubiquitin thiolesterase activity
Specific Function Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates. May also bind hyaluronan and RNA
Pathways Not Available
Reactions Not Available
GO Classification
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process
Cellular Location
  1. Nucleus
  2. nucleolus
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs USP17A
Gene Sequence 
>1593 bp
ATGGAGGACGACTCACTCTACTTGGGAGGTGAGTGGCAGTTCAACCACTTTTCAAAACTC
ACATCTTCTCGGCCAGATGCAGCTTTTGCTGAAATCCAGCGGACTTCTCTCCCTGAGAAG
TCACCACTTTCATGTGAGACCCGTGTCGACCTCTGTGACGATTTGGCTCCTGTGGCAAGA
CAGCTTGCTCCCAGGGAGAAGCTTCCTCTGAGTAGCAGGAGACCTGCTGCGGTGGGGGCT
GGGCTCCAGAATATGGGAAATACCTGCTACGTGAACGCTTCCTTGCAGTGCCTGACATAC
ACACCGCCCCTTGCCAACTACATGCTGTCCCGGGAGCACTCTCAAACGTGTCATCGTCAC
AAGGGCTGCATGCTCTGTACTATGCAAGCTCACATCACACGGGCCCTCCACAATCCTGGC
CACGTCATCCAGCCCTCACAGGCATTGGCTGCTGGCTTCCATAGAGGCAAGCAGGAAGAT
GCCCATGAATTTCTCATGTTCACTGTGGATGCCATGAAAAAGGCATGCCTTCCCGGGCAC
AAGCAGGTAGATCATCACTCTAAGGACACCACCCTCATCCACCAAATATTTGGAGGCTAC
TGGAGATCTCAAATCAAGTGTCTCCACTGCCACGGCATTTCAGACACTTTTGACCCTTAC
CTGGACATCGCCCTGGATATCCAGGCAGCTCAGAGTGTCCAGCAAGCTTTGGAACAGTTG
GTGAAGCCCGAAGAACTCAATGGAGAGAATGCCTATCATTGTGGTGTTTGTCTCCAGAGG
GCGTCGGCCTCCAAGACGTTAACTTTACACACCTCTGCCAAGGTCCTCATCCTTGTATTG
AAGAGATTCTCCGATGTCACAGGCAACAAGATTGCCAAGAATGTGCAATATCCTGAGTGC
CTTGACATGCAGCCATACATGTCTCAGCAGAACACAGGACCTCTTGTCTATGTCCTCTAT
GCTGTGCTGGTCCACGCTGGGTGGAGTTGTCACAACGGACATTACTTCTCTTATGTCAAA
GCTCAAGAAGGCCAGTGGTATAAAATGGATGATGCCGAGGTCACCGCCTCTAGCATCACT
TCTGTCCTGAGTCAACAGGCCTACGTCCTCTTTTACATCCAGAAGAGTGAATGGGAAAGA
CACAGTGAGAGTGTGTCAAGAGGCAGGGAACCAAGAGCCCTTGGCGCAGAAGACACAGAC
AGGCGAGCAACGCAAGGAGAGCTCAAGAGAGACCACCCCTGCCTCCAGGCCCCCGAGTTG
GACGAGCACTTGGTGGAAAGAGCCACTCAGGAAAGCACCTTAGACCACTGGAAATTCCTT
CAAGAGCAAAACAAAACGAAGCCTGAGTTCAACGTCAGAAAAGTCGAAGGTACCCTGCCT
CCCGACGTACTTGTGATTCATCAATCAAAATACAAGTGTGGGATGAAGAACCATCATCCT
GAACAGCAAAGCTCCCTGCTAAACCTCTCTTCGACGACACCGACACATCAGGAGTCCATG
AACACTGGCACACTCGCTTCCCTGCGAGGGAGGGCCAGGAGATCCAAAGGGAAGAACAAA
CACAGCAAGAGGGCTCTGCTTGTGTGCCAGTGA
Protein Properties
Number of Residues 530
Molecular Weight 59710.3
Theoretical pI 8.14
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Ubiquitin carboxyl-terminal hydrolase 17
MEDDSLYLRGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVAR
QLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH
KGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGH
KQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQL
VKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGNKIAKNVQYPEC
LDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSIT
SVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPEL
DEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHP
EQQSSLLNLSSSTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ
GenBank ID Protein 33333160
UniProtKB/Swiss-Prot ID Q0WX57
UniProtKB/Swiss-Prot Entry Name UBP17_HUMAN
PDB IDs Not Available
GenBank Gene ID AF544011
GeneCard ID USP17A
GenAtlas ID USP17A
HGNC ID HGNC:12615
References
General References
  1. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
  2. Saitoh Y, Miyamoto N, Okada T, Gondo Y, Showguchi-Miyata J, Hadano S, Ikeda JE: The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. Genomics. 2000 Aug 1;67(3):291-300. [PubMed:10936051 ]
  3. Shin JM, Yoo KJ, Kim MS, Kim D, Baek KH: Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. BMC Genomics. 2006 Nov 16;7:292. [PubMed:17109758 ]
  4. Okada T, Gondo Y, Goto J, Kanazawa I, Hadano S, Ikeda JE: Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene. Hum Genet. 2002 Apr;110(4):302-13. Epub 2002 Mar 16. [PubMed:11941478 ]
  5. Burrows JF, McGrattan MJ, Johnston JA: The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. Genomics. 2005 Apr;85(4):524-9. [PubMed:15780755 ]