| Identification |
|---|
| HMDB Protein ID
| HMDBP09380 |
| Secondary Accession Numbers
| |
| Name
| Testicular acid phosphatase |
| Synonyms
|
Not Available
|
| Gene Name
| ACPT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid phosphatase activity |
| Specific Function
| Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.
|
| Pathways
|
|
| Reactions
|
| A phosphate monoester + Water → an alcohol + Phosphate |
details
|
| Flavin mononucleotide + Water → Riboflavin + Phosphate |
details
|
|
| GO Classification
|
| Cellular Component |
| integral to membrane |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| acid phosphatase activity |
| Molecular Function |
| acid phosphatase activity |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein (Potential)
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13.4 |
| SNPs
| ACPT |
| Gene Sequence
|
>1281 bp
ATGGCCGGCCTGGGGTTTTGGGGCCACCCTGCTGGACCTCTCCTGCTGCTGCTGCTGCTG
GTGCTGCCACCCCGGGCCCTGCCAGAAGGACCCCTGGTGTTCGTGGCTCTGGTATTCCGC
CATGGCGACCGGGCCCCGCTGGCCTCCTACCCCATGGACCCACACAAGGAGGTGGCCTCC
ACCCTGTGGCCACGAGGCCTGGGCCAGCTGACCACGGAGGGGGTCCGCCAGCAGCTGGAG
CTGGGCCGCTTCCTGAGGAGCCGCTACGAGGCCTTCCTGAGTCCGGAGTACCGGCGGGAG
GAGGTGTACATCCGCAGCACGGACTTTGACCGCACGCTGGAGAGTGCCCAGGCCAACCTT
GCCGGGCTGTTTCCCGAGGCTGCTCCAGGGAGCCCCGAGGCCCGCTGGAGGCCGATCCCG
GTGCACACGGTGCCCGTGGCTGAGGATAAGCTGCTGAGGTTCCCCATGCGCAGCTGTCCC
CGATACCACGAGCTGCTGCGGGAGGCCACCGAGGCCGCCGAGTACCAGGAGGCCCTGGAG
GGCTGGACGGGCTTCCTGAGTCGCCTGGAGAACTTCACGGGACTGTCGCTGGTTGGAGAG
CCACTGCGCAGGGCATGGAAGGTTCTGGACACCCTCATGTGCCAGCAAGCCCACGGTCTT
CCACTACCAGCCTGGGCCTCCCCAGATGTCCTGCGGACTCTTGCCCAGATCTCGGCTTTG
GATATTGGAGCCCACGTGGGCCCACCCCGGGCAGCAGAGAAGGCCCAGCTGACAGGGGGG
ATCCTGCTGAATGCTATCCTTGCAAACTTCTCCCGGGTCCAGCGCCTGGGGCTGCCCCTC
AAGATGGTCATGTACTCAGCTCATGACAGCACCCTGCTGGCCCTCCAGGGGGCCCTGGGC
CTCTATGATGGACACACCCCGCCATATGCTGCCTGCCTCGGCTTTGAGTTCCGGAAGCAC
CTGGGGAATCCCGCCAAAGATGGAGGGAATGTCACCGTCTCCCTCTTCTACCGCAATGAC
TCCGCCCACCTGCCCCTGCCTCTCAGCCTCCCCGGGTGCCCGGCCCCCTGTCCACTAGGC
CGCTTCTACCAGCTGACTGCCCCGGCCCGGCCTCCCGCCCATGGGGTCTCCTGCCATGGC
CCCTATGAGGCTGCCATCCCCCCAGCTCCAGTGGTGCCCCTGCTGGCCGGAGCTGTAGCT
GTGCTGGTGGCACTCAGCTTGGGGCTGGGCCTGCTGGCCTGGAGACCAGGGTGCCTGCGG
GCCTTGGGGGGCCCCGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 426 |
| Molecular Weight
| 46089.015 |
| Theoretical pI
| 8.202 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Testicular acid phosphatase
MAGLGFWGHPAGPLLLLLLLVLPPRALPEGPLVFVALVFRHGDRAPLASYPMDPHKEVAS
TLWPRGLGQLTTEGVRQQLELGRFLRSRYEAFLSPEYRREEVYIRSTDFDRTLESAQANL
AGLFPEAAPGSPEARWRPIPVHTVPVAEDKLLRFPMRSCPRYHELLREATEAAEYQEALE
GWTGFLSRLENFTGLSLVGEPLRRAWKVLDTLMCQQAHGLPLPAWASPDVLRTLAQISAL
DIGAHVGPPRAAEKAQLTGGILLNAILANFSRVQRLGLPLKMVMYSAHDSTLLALQGALG
LYDGHTPPYAACLGFEFRKHLGNPAKDGGNVTVSLFYRNDSAHLPLPLSLPGCPAPCPLG
RFYQLTAPARPPAHGVSCHGPYEAAIPPAPVVPLLAGAVAVLVALSLGLGLLAWRPGCLR
ALGGPV
|
| External Links |
|---|
| GenBank ID Protein
| 12958660 |
| UniProtKB/Swiss-Prot ID
| Q9BZG2 |
| UniProtKB/Swiss-Prot Entry Name
| PPAT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF321918 |
| GeneCard ID
| ACPT |
| GenAtlas ID
| ACPT |
| HGNC ID
| HGNC:14376 |
| References |
|---|
| General References
| - Yousef GM, Diamandis M, Jung K, Diamandis EP: Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis. Genomics. 2001 Jun 15;74(3):385-95. [PubMed:11414767 ]
- Fleisig H, El-Din El-Husseini A, Vincent SR: Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. Neuroscience. 2004;127(1):91-100. [PubMed:15219672 ]
|
