Hmdb loader
Identification
HMDB Protein ID HMDBP09199
Secondary Accession Numbers
  • 14973
Name RNA pseudouridylate synthase domain-containing protein 2
Synonyms Not Available
Gene Name RPUSD2
Protein Type Enzyme
Biological Properties
General Function Involved in RNA binding
Specific Function Not Available
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
nucleic acid binding
isomerase activity
pseudouridine synthase activity
intramolecular transferase activity
rna binding
Process
rna metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna modification
pseudouridine synthesis
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:1
Locus 15q13.3
SNPs RPUSD2
Gene Sequence
>1638 bp
ATGTGGCTGGACCGCCGCGGATGGCTCAGGGTTCTTGGACATTGGCGCTACGACCTTAGG
CGCCCTAGCTTTACCAGGACTTGGAGTGGCGATAAGGGCCCAATGGCAGAAACAGTGTCT
ACCCAGGTTGGGACAGAGGGCGGGCTGAGGGCTTCGCATCAGCAAAACGGTGACGCTGGT
GGCGACGCGAAGGTTGAGCTGTCCCCCGGGCCCCCGAAGCCGGCTGGCCGGGAAGTGGAG
CCGGCCCCAGTAGGCGGGGAGCATCCCTCGGCTGCAGCCCCAGGCCCGGGCAAGCATAAG
AAGCGGCGGGGCGCAACCAGGGAGCGTGTCGTGCCGCCCCCGAAGAAGCGGCGGACCGGG
GTGAGCTTCGGAGATGAGCACTTTGCAGAAACCAGTTATTACTTCGAGGGCGGCCTGCGT
AAGGTGCGGCCCTATTACTTTGACTTCCGGACCTACTGCAAAGGTCGCTGGGTGGGCCAC
AGCTTGCTGCACGTCTTCAGTACCGAGTTCCGAGCTCAGCCCCTGGCCTACTATGAGGCC
GCGGTCCGGGCGGGCCGCCTGCAACTCAACGAGAAGCCGGTGCAGGACCTCAACATCGTG
CTCAAGGACAATGATTTCTTGCGGAACACAGTGCACAGGCATGAGCCACCAGTCACAGCA
GAGCCCATTCGCCTGCTAGCTGAGAACGAAGATGTGGTGGTTGTAGACAAGCCTTCCTCC
ATTCCCGTTCACCCCTGTGGCCGCTTCCGACACAACACAGTCATCTTCATCCTAGGCAAG
GAGCACCAACTCAAGGAGCTACACCCCTTGCATCGGCTTGACCGCCTTACCTCAGGGGTG
CTTATGTTTGCCAAGACAGCTGCAGTCTCTGAGAGAATTCACGAGCAGGTTCGGGACCGG
CAGCTGGAGAAGGAGTACGTGTGCCGGGTGGAAGGGGAGTTCCCCACTGAGGAAGTGACC
TGTAAAGAACCCATCTTAGTGGTGTCTTACAAAGTAGGGGTGTGCCGTGTAGATCCCCGG
GGCAAGCCCTGTGAGACAGTGTTCCAGAGGCTAAGCTACAATGGCCAGTCCAGTGTGGTA
CGGTGCCGGCCACTCACAGGCCGCACACACCAGATTCGAGTCCACCTTCAGTTCTTGGGC
CATCCCATTCTCAACGACCCCATCTACAACTCAGTTGCCTGGGGTCCTTCTCGAGGCCGG
GGCGGCTACATTCCCAAGACAAACGAGGAGTTGCTACGGGACCTGGTAGCAGAGCACCAG
GCCAAACAGAGCCTGGATGTGCTAGATCTCTGTGAGGGTGACCTGTCCCCAGGACTCACA
GACTCTACGGCCCCCTCCTCAGAGTTGGGCAAGGACGACCTGGAAGAGTTGGCTGCAGCT
GCCCAGAAGATGGAGGAAGTAGCTGAGGCAGCCCCTCAGGAGTTGGACACAATAGCCTTG
GCATCAGAGAAGGCAGTTGAAACAGATGTCATGAATCAAGAGACAGACCCACTCTGTGCA
GAGTGCCGGCTGGTGCGACAGGATCCCTTGCCCCAAGACCTTGTGATGTTCCTACATGCC
CTACGCTATAAAGGGCCAGGCTTTGAGTACTTTTCACCAATGCCTGCCTGGGCACAGGAT
GACTGGCAAAAGGACTGA
Protein Properties
Number of Residues 545
Molecular Weight 61311.0
Theoretical pI 7.18
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>RNA pseudouridylate synthase domain-containing protein 2
MWLDRRGWLRVLGHWRYDLRRPSFTRTWSGDKGPMAETVSTQVGTEGGLRASHQQNGDAG
GDAKVELSPGPPKPAGREVEPAPVGGEHPSAAAPGPGKHKKRRGATRERVVPPPKKRRTG
VSFGDEHFAETSYYFEGGLRKVRPYYFDFRTYCKGRWVGHSLLHVFSTEFRAQPLAYYEA
AVRAGRLQLNEKPVQDLNIVLKDNDFLRNTVHRHEPPVTAEPIRLLAENEDVVVVDKPSS
IPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSERIHEQVRDR
QLEKEYVCRVEGEFPTEEVTCKEPILVVSYKVGVCRVDPRGKPCETVFQRLSYNGQSSVV
RCRPLTGRTHQIRVHLQFLGHPILNDPIYNSVAWGPSRGRGGYIPKTNEELLRDLVAEHQ
AKQSLDVLDLCEGDLSPGLTDSTAPSSELGKDDLEELAAAAQKMEEVAEAAPQELDTIAL
ASEKAVETDVMNQETDPLCAECRLVRQDPLPQDLVMFLHALRYKGPGFEYFSPMPAWAQD
DWQKD
GenBank ID Protein 16550833
UniProtKB/Swiss-Prot ID Q8IZ73
UniProtKB/Swiss-Prot Entry Name RUSD2_HUMAN
PDB IDs Not Available
GenBank Gene ID AK055971
GeneCard ID RPUSD2
GenAtlas ID RPUSD2
HGNC ID HGNC:24180
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]