| Identification |
|---|
| HMDB Protein ID
| HMDBP08961 |
| Secondary Accession Numbers
| |
| Name
| Pyruvate kinase |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in magnesium ion binding |
| Specific Function
| ATP + pyruvate = ADP + phosphoenolpyruvate |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| magnesium ion binding |
| alkali metal ion binding |
| potassium ion binding |
| pyruvate kinase activity |
| Process |
| metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| monosaccharide metabolic process |
| hexose metabolic process |
| glucose metabolic process |
| glucose catabolic process |
| glycolysis |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
>1764 bp
CATTCCATGGTCCCGCAGCCCCAGGCCCACACTGAAAGCATGTCGATCCAGGAGAACATA
TCATCCCTGCAGCTTCGGTCATGGGTCTCTAAGTCCCAAAGAGACTTAGCAAAGTCCATC
CTGATTGGGGCTCCAGGAGGGCCAGCGGGGTATCTGCGGCGGGCCAGTGTGGCCCAACTG
ACCCAGGAGCTGGGCACTGCCTTCTTCCAGCAGCAGCAGCTGCCAGCTGCTATGGCAGAC
ACCTTCCTGGAACACCTCTGCCTACTGGACATTGACTCCGAGCCCGTGGCTGCTCGCAGT
ACCAGCATCATTGCCACCATCGGGCCAGCATCTCGCTCCGTGGAGCGCCTCAAGGAGATG
ATCAAGGCCGGGATGAACATTGCGCGACTCAACTTCTCCCACGGCTCCCACGAGTACCAT
GCTGAGTCCATCGCCAACGTCCGGGAGGCGGTGGAGAGCTTTGCAGGTTCCCCACTCAGC
TACCGGCCCGTGGCCATCGCCCTGGACACCAAGGGACCGGAGATCCGCACTGGGATCCTG
CAGGGGGGTCCAGAGTCGGAAGTGGAGCTGGTGAAGGGCTCCCAGGTGCTGGTGACTGTG
GACCCCGCGTTCCGGACGCGGGGGAACGCGAACACCGTGTGGGTGGACTACCCCAATATT
GTCCGGGTCGTGCCGGTGGGGGGCCGCATCTACATTGACGACGGGCTCATCTCCCTAGTG
GTCCAGAAAATCGGCCCAGAGGGACTGGTGACCCAAGTGGAGAACGGCGGCGTCCTGGGC
AGCCGGAAGGGCGTGAACTTGCCAGGGGCCCAGGTGGACTTGCCCGGGCTGTCCGAGCAG
GACGTCCGAGACCTGCGCTTCGGGGTGGAGCATGGGGTGGACATCGTCTTTGCCTCCTTT
GTGCGGAAAGCCAGCGACGTGGCTGCCGTCAGGGCTGCTCTGGGTCCGGAAGGACACGGC
ATCAAGATCATCAGCAAAATTGAGAACCACGAAGGCGTGAAGAGGTTTGATGAAATCCTG
GAGGTGAGCGACGGCATCATGGTGGCACGGGGGGACCTAGGCATCGAGATCCCAGCAGAG
AAGGTTTTCCTGGCTCAGAAGATGATGATTGGGCGCTGCAACTTGGCGGGCAAGCCTGTT
GTCTGTGCCACACAGATGCTGGAGAGCATGATTACCAAGCCCCGGCCAACGAGGGCAGAG
ACAAGCGATGTCGCCAATGCTGTGCTGGATGGGGCTGACTGCATCATGCTGTCAGGGGAG
ACTGCCAAGGGCAACTTCCCTGTGGAAGCGGTGAAGATGCAGCATGCGATTGCCCGGGAG
GCAGAGGCCGCAGTGTACCACCGGCAGCTGTTTGAGGAGCTACGTCGGGCAGCGCCACTA
AGCCGTGATCCCACTGAGGTCACCGCCATTGGTGCTGTGGAGGCTGCCTTCAAGTGCTGT
GCTGCTGCCATCATTGTGCTGACCACAACTGGCCGCTCAGCCCAGCTTCTGTCTCGGTAC
CGACCTCGGGCAGCAGTCATTGCTGTCACCCGCTCTGCCCAGGCTGCCCGCCAGGTCCAC
TTATGCCGAGGAGTCTTCCCCTTGCTTTACCGTGAACCTCCAGAAGCCATCTGGGCAGAT
GATGTAGATCGCCGGGTGCAATTTGGCATTGAAAGTGGAAAGCTCCGTGGCTTCCTCCGT
GTTGGAGACCTGGTGATTGTGGTGACAGGCTGGCGACCTGGCTCCGGCTACACCAACATC
ATGCGGGTGCTAAGCATATCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 587 |
| Molecular Weight
| 63260.1 |
| Theoretical pI
| 7.6 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Pyruvate kinase
HSMVPQPQAHTESMSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQL
TQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEM
IKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGIL
QGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLV
VQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASF
VRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAE
KVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGE
TAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCC
AAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWAD
DVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
|
| External Links |
|---|
| GenBank ID Protein
| 1230589 |
| UniProtKB/Swiss-Prot ID
| Q16715 |
| UniProtKB/Swiss-Prot Entry Name
| Q16715_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U47654 |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:9020 |
| References |
|---|
| General References
| - Lenzner C, Nurnberg P, Jacobasch G, Thiele BJ: Complete genomic sequence of the human PK-L/R-gene includes four intragenic polymorphisms defining different haplotype backgrounds of normal and mutant PK-genes. DNA Seq. 1997;8(1-2):45-53. [PubMed:9522120 ]
|
