Hmdb loader
Identification
HMDB Protein ID HMDBP08808
Secondary Accession Numbers
  • 14533
Name Ribonuclease H1
Synonyms
  1. RNase H1
  2. Ribonuclease H type II
Gene Name RNASEH1
Protein Type Unknown
Biological Properties
General Function Involved in nucleic acid binding
Specific Function Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
endoribonuclease activity, producing 5'-phosphomonoesters
hydrolase activity
ribonuclease h activity
magnesium ion binding
nucleic acid binding
nuclease activity
endonuclease activity
endoribonuclease activity
Cellular Location
  1. Cytoplasm (Potential)
Gene Properties
Chromosome Location Chromosome:2
Locus 2p25
SNPs RNASEH1
Gene Sequence
>861 bp
ATGAGCTGGCTTCTGTTCCTGGCCCACAGAGTCGCCTTGGCCGCCTTGCCCTGCCGCCGC
GGCTCTCGCGGGTTCGGGATGTTCTATGCCGTGAGGAGGGGCCGCAAGACCGGGGTCTTT
CTGACCTGGAATGAGTGCAGAGCACAGGTGGACCGGTTTCCTGCTGCCAGATTTAAGAAG
TTTGCCACAGAGGATGAGGCCTGGGCCTTTGTCAGGAAATCTGCAAGCCCGGAAGTTTCA
GAAGGGCATGAAAATCAACATGGACAAGAATCGGAGGCGAAAGCCAGCAAGCGACTCCGT
GAGCCACTGGATGGAGATGGACATGAAAGCGCAGAGCCGTATGCAAAGCACATGAAGCCG
AGCGTGGAGCCGGCGCCTCCAGTTAGCAGAGACACGTTTTCCTACATGGGAGACTTCGTC
GTCGTCTACACTGATGGCTGCTGCTCCAGTAATGGGCGTAGAAGGCCGCGAGCAGGAATC
GGCGTTTACTGGGGGCCAGGCCATCCTTTAAATGTAGGCATTAGACTTCCTGGGCGGCAG
ACAAACCAAAGAGCGGAAATTCATGCAGCCTGCAAAGCCATTGAACAAGCAAAGACTCAA
AACATCAATAAACTGGTTCTGTATACAGACAGTATGTTTACGATAAATGGTATAACTAAC
TGGGTTCAAGGTTGGAAGAAAAATGGGTGGAAGACAAGTGCAGGGAAAGAGGTGATCAAC
AAAGAGGACTTTGTGGCACTGGAGAGGCTTACCCAGGGGATGGACATTCAGTGGATGCAT
GTTCCTGGTCATTCGGGATTTATAGGCAATGAAGAAGCTGACAGATTAGCCAGAGAAGGA
GCTAAACAATCGGAAGACTGA
Protein Properties
Number of Residues 286
Molecular Weight 32064.0
Theoretical pI 9.6
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ribonuclease H1
MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKK
FATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKP
SVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQ
TNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVIN
KEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED
GenBank ID Protein 62420309
UniProtKB/Swiss-Prot ID O60930
UniProtKB/Swiss-Prot Entry Name RNH1_HUMAN
PDB IDs Not Available
GenBank Gene ID AC108488
GeneCard ID RNASEH1
GenAtlas ID RNASEH1
HGNC ID HGNC:18466
References
General References
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