Showing Protein GTPase RhebL1 (HMDBP08536)

• 14248

1. Ras homolog enriched in brain like-1 c
2. Ras homolog enriched in brain-like protein 1
3. Rheb-like protein 1
4. Rheb2
5. RhebL1c

1. Cell membrane
2. Lipid-anchor
3. Cytoplasm
4. Cytoplasmic side

>552 bp
ATGCCGCTAGTCCGCTACAGGAAGGTGGTCATCCTCGGATACCGCTGTGTAGGGAAGACA
TCTTTGGCACATCAATTTGTGGAAGGCGAGTTCTCGGAAGGCTACGATCCTACAGTGGAG
AATACTTACAGCAAGATAGTGACTCTTGGCAAAGATGAGTTTCACCTACATCTGGTGGAC
ACAGCAGGGCAGGATGAGTACAGCATTCTGCCCTATTCATTCATCATTGGGGTCCATGGT
TATGTGCTTGTGTATTCTGTCACCTCTCTGCATAGCTTCCAAGTCATTGAGAGTCTGTAC
CAAAAGCTACATGAAGGCCATGGGAAAACCCGGGTGCCAGTGGTTCTAGTGGGGAACAAG
GCAGATCTCTCTCCAGAGAGAGAGGTACAGGCAGTTGAAGGAAAGAAGCTGGCAGAGTCC
TGGGGTGCGACATTTATGGAGTCATCTGCTCGAGAGAATCAGCTGACTCAAGGCATCTTC
ACCAAAGTCATCCAGGAGATTGCCCGTGTGGAGAATTCCTATGGGCAAGAGCGTCGCTGC
CATCTCATGTGA

• Ras (PF00071 )

• None

• None

>GTPase RhebL1
MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD
TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK
ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRC
HLM

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3. Yuan J, Shan Y, Chen X, Tang W, Luo K, Ni J, Wan B, Yu L: Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. Mol Biol Rep. 2005 Dec;32(4):205-14. [PubMed:16328882 ]
4. Tabancay AP Jr, Gau CL, Machado IM, Uhlmann EJ, Gutmann DH, Guo L, Tamanoi F: Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J Biol Chem. 2003 Oct 10;278(41):39921-30. Epub 2003 Jul 17. [PubMed:12869548 ]
5. Tee AR, Blenis J, Proud CG: Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett. 2005 Aug 29;579(21):4763-8. [PubMed:16098514 ]
6. Basso AD, Mirza A, Liu G, Long BJ, Bishop WR, Kirschmeier P: The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity. J Biol Chem. 2005 Sep 2;280(35):31101-8. Epub 2005 Jul 8. [PubMed:16006564 ]
7. Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP: Activation of the mTOR signaling pathway in renal clear cell carcinoma. J Urol. 2007 Jan;177(1):346-52. [PubMed:17162089 ]