Hmdb loader
Identification
HMDB Protein ID HMDBP08395
Secondary Accession Numbers
  • 14107
Name FYVE, RhoGEF and PH domain-containing protein 6
Synonyms
  1. Zinc finger FYVE domain-containing protein 24
Gene Name FGD6
Protein Type Unknown
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
transition metal ion binding
zinc ion binding
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location
  1. Cytoplasm
  2. Cytoplasm (Probable)
  3. cytoskeleton (Probable)
Gene Properties
Chromosome Location Chromosome:1
Locus 12q22
SNPs FGD6
Gene Sequence
>4293 bp
ATGACTTCTGCAGCCGAGATAAAGAAGCCACCAGTGGCCCCCAAGCCCAAGTTTGTTGTG
GCAAATAATAAGCCAGCCCCACCTCCTATTGCACCTAAACCCGACATTGTGATTTCTAGT
GTTCCACAGTCGACAAAGAAAATGAAACCAGCAATAGCCCCAAAACCAAAAGTCCTGAAG
ACCTCACCTGTTCGAGAGATTGGGCAGTCGCCATCAAGGAAAATCATGTTGAACCTGGAA
GGGCATAAACAGGAATTAGCTGAAAGCACTGACAACTTTAATTGTAAATATGAAGGCAAT
CAGAGCAATGATTATATTTCACCAATGTGTTCCTGCAGTTCTGAGTGTATCCATAAGCTG
GGCCATAGAGAGAATTTGTGTGTAAAGCAGCTTGTTTTAGAGCCCCTGGAAATGAATGAA
AATTTAGAAAACAGTAAAATTGATGAGACTTTGACTATAAAAACTAGGAGTAAATGTGAT
TTGTATGGTGAAAAAGCCAAGAACCAGGGTGGGGTTGTTTTAAAGGCAAGCGTTTTAGAA
GAGGAGCTCAAAGATGCCTTAATACACCAAATGCCACCTTTTATTTCTGCACAGAAGCAC
AGGCCCACAGACAGCCCAGAAATGAATGGTGGCTGTAATTCAAATGGACAATTCAGAATT
GAATTTGCGGATTTGTCACCTTCCCCATCCAGCTTTGAAAAAGTTCCTGATCATCACAGT
TGCCACTTACAGCTTCCTAGTGATGAATGTGAACATTTTGAAACTTGCCAGGATGACAGT
GAAAAAAGCAATAATTGCTTTCAGTCATCTGAACTAGAGGCTCTGGAAAATGGGAAAAGG
AGTACTTTAATATCTTCAGATGGAGTTAGTAAGAAATCAGAAGTCAAAGACCTTGGTCCC
TTAGAAATTCATTTAGTACCATATACCCCAAAATTTCCAACTCCCAAGCCCAGAAAGACA
CGAACTGCTCGTCTGTTACGCCAAAAGTGTGTAGATACTCCTAGTGAAAGCACTGAAGAA
CCGGGGAATTCAGACAGTAGCTCTTCCTGTCTTACTGAAAATAGTTTGAAAATCAATAAA
ATCAGTGTTCTGCATCAGAATGTTTTGTGTAAGCAGGAACAGGTGGATAAAATGAAGCTA
GGAAATAAAAGTGAATTGAATATGGAATCCAACAGTGATGCACAGGACTTAGTCAATTCA
CAGAAAGCCATGTGTAATGAAACAACTTCCTTTGAAAAAATGGCACCTTCTTTTGATAAA
GACTCTAATTTGAGTTCTGACAGCACAACTGTAGATGGTTCTAGTATGTCGCTTGCTGTG
GACGAAGGGACCGGTTTTATAAGATGTACTGTATCTATGAGCCTGCCTAAGCAGCTCAAA
TTAACTTGCAATGAACATTTGCAATCTGGGAGAAACCTGGGAGTTTCTGCCCCTCAAATG
CAAAAGGAATCTGTTATAAAAGAGGAAAATTCTCTACGAATTGTCCCCAAAAAACCTCAA
AGACATAGCTTGCCTGCTACAGGAGTGCTTAAAAAGGCTGCCTCCGAGGAGCTTTTGGAA
AAAAGTTCTTATCCTTCAAGTGAAGAAAAAAGTTCAGAGAAGAGTCTAGAAAGAAATCAC
CTTCAGCATTTGTGTGCCCAAAACCGTGGTGTGTCATCCTCCTTTGATATGCCTAAACGG
GCTTCAGAAAAGCCAGTGTGGAAGTTACCTCATCCTATTTTACCCTTTTCAGGGAACCCA
GAATTCTTAAAGTCTGTCACCGTATCGTCAAACAGTGAGCCTTCAACAGCCCTAACCAAG
CCCAGAGCAAAATCGTTATCTGCTATGGATGTGGAAAAGTGCACTAAGCCTTGCAAAGAC
TCTACAAAGAAAAACTCTTTTAAAAAGTTGCTCAGCATGAAACTGTCCATCTGTTTCATG
AAGAGTGACTTTCAAAAATTTTGGTCCAAGAGTAGCCAACTCGGAGACACCACCACAGGC
CACCTCTCCAGTGGGGAGCAGAAGGGGATTGAAAGTGATTGGCAAGGCTTGTTGGTAGGA
GAGGAGAAGAGAAGTAAACCCATCAAGGCATATTCCACAGAAAACTATAGCCTGGAATCT
CAAAAGAAGAGGAAGAAGTCTCGGGGCCAGACCAGTGCAGCTAATGGTCTGAGAGCTGAG
TCTTTGGATGACCAAATGCTCTCCCGGGAGTCATCATCTCAGGCACCTTACAAGTCTGTT
ACAAGCCTCTGTGCACCGGAGTATGAAAATATACGCCATTATGAGGAAATACCAGAGTAC
GAGAACTTGCCATTTATTATGGCTATACGGAAAACTCAAGAGTTGGAATGGCAGAATTCC
AGCAGCATGGAGGACGCTGATGCAAATGTGTATGAGGTAGAAGAGCCGTATGAAGCTCCA
GATGGCCAGCTGCAGCTTGGACCCAGACATCAGCATTCCAGTTCAGGAGCATCCCAGGAG
GAACAGAATGATCTTGGTCTTGGTGACCTTCCCTCTGATGAGGAGGAAATCATCAACAGT
TCTGATGAAGATGATGTCAGCTCTGAGTCAAGTAAAGGAGAGCCTGACCCACTGGAAGAT
AAACAGGATGAAGATAATGGAATGAAAAGTAAAGTTCATCATATTGCCAAGGAGATCATG
AGCTCAGAGAAAGTGTTTGTGGATGTGTTAAAACTTTTGCATATTGATTTCCGGGATGCA
GTAGCTCATGCTTCCAGGCAACTTGGGAAACCAGTGATTGAGGACCGGATTCTAAATCAG
ATCCTATACTACTTGCCTCAGCTGTATGAGCTCAACCGGGATCTCTTGAAGGAACTGGAG
GAAAGAATGTTGCACTGGACTGAACAACAAAGAATTGCTGATATCTTTGTAAAGAAGGGA
CCATATCTAAAAATGTATTCCACATACATCAAAGAATTTGATAAGAATATAGCCTTGCTG
GATGAACAGTGCAAGAAAAATCCAGGTTTTGCTGCTGTTGTTAGAGAATTTGAGATGAGC
CCTCGCTGTGCTAATCTGGCCCTCAAGCACTACCTGCTCAAGCCGGTTCAGAGGATCCCC
CAGTACAGGCTGTTGCTGACAGATTATTTGAAGAATCTCATAGAAGATGCTGGAGATTAC
AGAGACACTCAAGATGCCCTTGCTGTTGTTATAGAGGTAGCCAACCACGCCAATGACACC
ATGAAGCAAGGAGACAACTTTCAGAAACTTATGCAAATTCAGTACAGCTTAAATGGACAC
CATGAAATTGTGCAGCCTGGTCGGGTTTTTCTCAAAGAAGGAATTCTGATGAAGCTGTCT
CGGAAAGTGATGCAACCTCGAATGTTTTTCCTGTTTAATGATGCCCTGCTGTATACAACA
CCAGTGCAGTCTGGGATGTATAAACTGAACAACATGCTCTCACTGGCTGGAATGAAGGTC
AGAAAACCTACCCAAGAAGCCTATCAGAATGAATTAAAGATTGAAAGTGTAGAACGTTCC
TTCATTCTCTCAGCCAGTTCTGCCACAGAAAGGGATGAATGGCTAGAAGCGATTTCCAGG
GCAATAGAAGAGTATGCCAAGAAAAGAATCACCTTCTGTCCTAGTAGGAGTCTTGATGAG
GCAGACTCAGAAAATAAAGAAGAAGTTAGTCCTCTTGGATCGAAGGCTCCCATCTGGATT
CCTGATACCAGAGCCACAATGTGTATGATCTGCACAAGCGAATTCACTCTCACCTGGAGA
CGACACCACTGCCGGGCCTGTGGAAAGATTGTATGCCAAGCTTGTTCGTCTAATAAGTAT
GGCTTAGATTACCTGAAAAATCAACCAGCAAGAGTATGTGAACATTGTTTCCAAGAACTG
CAGAAATTAGATCACCAGCACTCCCCTAGGATTGGATCTCCTGGAAATCACAAATCTCCT
TCAAGTGCCTTATCATCAGTCTTACATAGCATTCCATCAGGGAGGAAACAGAAAAAAATC
CCAGCTGCTCTCAAAGAAGTATCAGCAAACACAGAGGATTCTTCTATGAGTGGCTACTTG
TACAGATCAAAGGGCAATAAAAAACCCTGGAAACACTTTTGGTTTGTCATAAAAAATAAA
GTACTATATACATATGCTGCAAGTGAGGACGTGGCCGCTTTGGAGAGTCAGCCTTTATTA
GGATTCACTGTTATTCAAGTTAAAGATGAGAATTCCGAGTCTAAAGTATTTCAGTTACTG
CACAAAAACATGTTATTTTATGTATTCAAAGCAGAGGATGCTCATTCGGCTCAGAAGTGG
ATAGAAGCATTTCAGGAAGGCACAATATTGTAG
Protein Properties
Number of Residues 1430
Molecular Weight 160814.9
Theoretical pI 7.03
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>FYVE, RhoGEF and PH domain-containing protein 6
MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLK
TSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKL
GHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLE
EELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHS
CHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGP
LEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINK
ISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDK
DSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQM
QKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNH
LQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTK
PRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTG
HLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAE
SLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNS
SSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINS
SDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDA
VAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKG
PYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIP
QYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGH
HEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKV
RKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDE
ADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKY
GLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKI
PAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLL
GFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL
GenBank ID Protein 154240686
UniProtKB/Swiss-Prot ID Q6ZV73
UniProtKB/Swiss-Prot Entry Name FGD6_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_018351.3
GeneCard ID FGD6
GenAtlas ID FGD6
HGNC ID HGNC:21740
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
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