Showing Protein Dedicator of cytokinesis protein 6 (HMDBP08357)
Identification | |||||||||||||||
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HMDB Protein ID | HMDBP08357 | ||||||||||||||
Secondary Accession Numbers |
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Name | Dedicator of cytokinesis protein 6 | ||||||||||||||
Synonyms | Not Available | ||||||||||||||
Gene Name | DOCK6 | ||||||||||||||
Protein Type | Unknown | ||||||||||||||
Biological Properties | |||||||||||||||
General Function | Involved in guanyl-nucleotide exchange factor activity | ||||||||||||||
Specific Function | Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP | ||||||||||||||
Pathways | Not Available | ||||||||||||||
Reactions | Not Available | ||||||||||||||
GO Classification |
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Cellular Location | Not Available | ||||||||||||||
Gene Properties | |||||||||||||||
Chromosome Location | Chromosome:1 | ||||||||||||||
Locus | 19p13.2 | ||||||||||||||
SNPs | DOCK6 | ||||||||||||||
Gene Sequence |
>6144 bp ATGGCTGCCTCCGAGCGCCGCGCCTTCGCGCACAAGATCAACAGGACGGTGGCCGCAGAG GTGCGGAAGCAGGTGTCCCGGGAACGCAGTGGCTCCCCCCACTCCAGCAGGCGCTGCAGC AGCTCCCTGGGGGTCCCACTGACTGAAGTTGTCGAGCCCCTGGACTTTGAGGATGTACTT CTGAGCCGGCCACCAGATGCTGAGCCCGGGCCCCTCAGGGACCTGGTAGAATTCCCAGCT GATGACTTGGAGCTGCTGCTGCAGCCCCGGGAATGCCGGACCACGGAGCCCGGGATCCCC AAGGATGAAAAACTGGATGCCCAGGTGAGGGCCGCGGTGGAGATGTATATTGAGGACTGG GTCATTGTCCACAGAAGGTATCAGTACCTGAGTGCAGCATACAGCCCCGTCACCACAGAC ACACAGCGGGAGCGACAGAAGGGCCTCCCCCGCCAGGTCTTTGAGCAGGATGCTTCTGGA GACGAGAGGTCCGGCCCTGAGGACTCGAATGACTCCCGGCGTGGCTCGGGCTCCCCGGAA GACACCCCTCGAAGCAGTGGTGCCTCTAGCATCTTCGACCTGAGGAACCTGGCAGCTGAC TCATTGCTGCCCTCTCTGCTAGAGCGGGCGGCCCCAGAAGATGTGGACCGGCGCAATGAA ACCCTTCGACGGCAGCACCGGCCCCCGGCCCTGCTCACCCTCTACCCGGCACCTGACGAG GATGAAGCCGTGGAACGCTGTAGCCGCCCAGAGCCACCCCGCGAGCACTTTGGACAAAGG ATCTTGGTCAAGTGTCTGTCGCTCAAGTTCGAGATTGAAATTGAGCCCATCTTTGGGATC TTGGCTCTGTATGATGTGCGGGAGAAAAAGAAGATCTCGGAGAACTTCTACTTCGACCTG AACTCGGACTCCATGAAGGGGCTGCTTCGGGCTCATGGCACCCACCCTGCCATCTCCACC CTGGCCCGCTCTGCCATCTTCTCTGTGACCTACCCCTCACCTGACATCTTCCTGGTCATC AAGTTGGAGAAGGTGCTTCAGCAAGGGGACATCAGTGAGTGCTGTGAGCCTTACATGGTG TTGAAAGAAGTGGACACAGCCAAGAACAAAGAGAAGCTAGAGAAGCTGCGCCTGGCGGCC GAGCAGTTCTGCACCCGCCTGGGCCGCTACCGCATGCCCTTCGCCTGGACGGCCGTGCAC TTGGCCAACATCGTGAGCAGCGCTGGGCAGCTGGACCGGGACTCTGACTCGGAGGGCGAG CGCCGGCCAGCCTGGACAGACCGCCGCCGTCGGGGGCCCCAGGACCGGGCGAGTAGTGGG GACGACGCCTGCAGCTTCTCTGGCTTCCGTCCAGCCACGCTAACTGTCACAAACTTCTTT AAGCAGGAGGCTGAGCGACTCAGTGACGAGGACCTCTTCAAGTTCCTGGCTGACATGAGG CGCCCGTCGTCCCTGCTGCGGCGACTACGTCCTGTGACTGCCCAGCTCAAGATCGACATT TCTCCGGCTCCTGAAAATCCCCACTTCTGCCTCTCCCCTGAGCTGCTTCATATCAAGCCC TACCCGGACCCCAGGGGCCGGCCCACCAAGGAGATTCTGGAGTTCCCCGCCCGCGAAGTC TATGCCCCCCATACCAGCTACAGGAACCTGCTGTACGTGTACCCGCACAGCCTCAACTTC AGCAGCCGCCAGGGCTCCGTGCGCAACCTTGCTGTGCGAGTGCAGTACATGACAGGCGAG GACCCCAGCCAGGCTCTGCCGGTCATCTTTGGCAAGTCCAGCTGCAGTGAATTTACCCGC GAGGCCTTCACACCGGTGGTCTACCATAACAAGTCCCCCGAGTTCTACGAGGAGTTCAAG CTGCATCTTCCAGCCTGCGTGACAGAGAACCATCACCTGCTGTTCACCTTCTACCATGTC AGCTGCCAGCCCCGGCCGGGCACTGCCCTGGAGACACCCGTGGGCTTTACTTGGATCCCA CTGCTGCAGCACGGGCGCCTGAGGACCGGCCCCTTCTGTCTCCCAGTGTCTGTGGACCAG CCGCCGCCCAGCTATTCCGTGCTCACACCCGATGTGGCGCTTCCGGGCATGCGCTGGGTG GACGGTCACAAGGGCGTGTTCAGTGTGGAGCTCACAGCCGTGTCCTCTGTGCACCCCCAG GACCCCTACCTGGACAAATTCTTCACCCTGGTGCACGTCCTGGAGGAGGGAGCCTTCCCA TTCCGGCTCAAGGACACTGTGCTGAGCGAGGGCAACGTGGAGCAGGAGCTGCGGGCCAGT CTTGCAGCACTGCGCCTGGCCAGCCCCGAACCCCTTGTGGCCTTCTCCCACCACGTGCTG GACAAGCTCGTGCGTCTGGTCATCAGGCCCCCGATCATCAGTGGCCAGATTGTGAACCTG GGCCGTGGAGCCTTTGAAGCAATGGCCCATGTAGTCAGCCTTGTTCACCGGAGCCTGGAG GCAGCCCAGGATGCCCGCGGTCACTGCCCACAGCTGGCTGCCTACGTCCACTACGCCTTT CGCCTTCCTGGCACTGAGCCCAGCCTCCCGGATGGGGCCCCTCCAGTGACAGTGCAGGCT GCCACACTGGCCCGTGGCTCTGGTCGCCCCGCAAGCCTCTACCTGGCGCGTTCCAAGAGC ATCAGCAGCAGCAACCCTGACCTCGCCGTGGCCCCTGGCTCTGTGGATGACGAGGTTTCC CGCATCCTGGCCAGCAAGCTGCTTCACGAGGAGCTGGCTCTGCAGTGGGTGGTCAGCAGC AGTGCCGTACGCGAGGCCATCCTCCAGCACGCCTGGTTCTTCTTCCAGCTCATGGTGAAG AGTATGGCGCTGCACCTGCTGCTTGGCCAGCGACTAGACACACCCCGCAAGCTGCGCTTC CCCGGACGCTTCCTGGACGACATCACTGCCTTGGTGGGCTCTGTGGGCCTGGAGGTCATC ACCCGTGTCCACAAGGATGTGGAGCTGGCCGAGCACCTCAACGCCAGCCTGGCTTTCTTC CTCAGTGACCTTCTGTCCCTGGTGGACCGGGGCTTTGTCTTCAGCCTGGTCCGGGCCCAC TACAAGCAGGTGGCCACGCGGCTCCAGTCGTCCCCTAATCCAGCAGCCCTGCTGACCCTG CGCATGGAATTCACCCGCATCCTGTGCAGCCACGAGCACTACGTGACCCTCAACCTCCCC TGCTGCCCCCTGTCACCTCCAGCCTCGCCCTCCCCCTCTGTGTCCTCCACCACCTCCCAG AGCTCCACCTTCTCCAGCCAAGCCCCGGACCCCAAGGTGACCAGCATGTTCGAACTGAGT GGACCATTCCGGCAGCAGCACTTCCTAGCTGGGCTCCTGCTGACGGAGCTGGCACTGGCC CTCGAACCTGAGGCTGAAGGGGCATTCCTGTTGCACAAGAAGGCCATCAGTGCTGTGCAC AGCCTGCTATGTGGCCATGACACTGACCCCCGCTACGCCGAGGCCACTGTGAAGGCTCGT GTGGCCGAGCTGTACCTGCCACTGCTATCGATTGCACGGGATACCTTGCCACGGCTGCAT GACTTTGCTGAGGGCCCAGGTCAGCGGTCAAGACTGGCCTCAATGCTTGACTCAGACACA GAAGGCGAAGGGGACATTGCGGGTACCATCAACCCCTCTGTGGCCATGGCCATTGCTGGT GGCCCCCTAGCCCCTGGCTCCCGGGCCAGCATCTCCCAGGGGCCACCAACGGCTTCTCGC GCAGGCTGTGCCCTCTCTGCTGAGTCAAGCCGGACCTTGCTGGCGTGTGTGCTGTGGGTG CTGAAAAACACCGAGCCGGCGCTCCTGCAGCGCTGGGCCACTGACCTGACACTCCCCCAG CTGGGACGTCTGTTGGATTTGCTGTACCTTTGCCTAGCTGCCTTTGAGTACAAGGGGAAA AAGGCCTTTGAACGCATCAACAGCCTCACATTCAAAAAATCTCTGGATATGAAGGCGCGG CTAGAGGAAGCCATTCTGGGTACCATCGGAGCTCGACAAGAAATGGTTCGGCGAAGTCGT GAGAGGAGCCCGTTTGGGAATCCGGAGAATGTGCGCTGGCGGAAGAGCGTCACACACTGG AAGCAAACCTCAGACCGCGTGGACAAGACCAAGGATGAAATGGAACACGAGGCCTTGGTG GAAGGGAACCTGGCAACCGAGGCAAGCCTAGTGGTTCTGGACACACTGGAGATCATCGTG CAGACGGTGATGCTTTCAGAAGCCCGGGAGAGCGTCTTGGGGGCAGTGCTGAAGGTTGTG CTGTACAGCCTGGGCAGTGCCCAGAGTGCCCTCTTCTTGCAGCATGGCCTGGCCACCCAG AGGGCCCTTGTGTCCAAGTTCCCGGAGCTGCTGTTCGAGGAGGACACGGAGCTGTGTGCC GACCTGTGCCTGAGGCTCCTACGACACTGTGGCAGCCGCATCAGCACCATCCGCACGCAC GCCAGCGCCTCGCTGTACCTGCTCATGCGACAGAACTTCGAGATCGGCCACAACTTTGCC CGTGTGAAGATGCAGGTCACCATGTCTCTCTCGTCCCTGGTGGGGACGACGCAGAACTTC AGTGAAGAGCACCTGCGACGTTCACTCAAAACCATCCTCACCTATGCTGAGGAGGACATG GGGCTGCGGGACAGCACCTTCGCAGAGCAGGTCCAGGACCTGATGTTCAACCTGCACATG ATCCTGACGGACACGGTGAAGATGAAGGAACACCAGGAGGACCCTGAGATGCTCATCGAC CTCATGTACAGAATTGCCCGGGGCTACCAGGGCTCACCGGACCTTCGGCTGACCTGGTTG CAGAACATGGCCGGGAAGCACGCGGAGCTGGGCAACCACGCCGAGGCCGCCCAGTGCATG GTGCACGCGGCCGCCCTCGTGGCTGAGTACCTCGCCCTGCTCGAGGACCACCGCCACCTG CCCGTGGGCTGCGTTTCCTTCCAGAACATCTCATCCAACGTGCTAGAGGAGTCCGCCATC TCCGACGACATCCTGTCGCCCGACGAGGAGGGCTTCTGCTCCGGGAAGCACTTCACTGAG CTGGGGCTGGTAGGGTTGCTGGAACAGGCAGCCGGCTACTTCACCATGGGCGGGCTCTAC GAGGCGGTGAATGAGGTCTACAAGAACCTCATCCCCATCCTGGAAGCCCACCGTGACTAC AAGAAGCTGGCCGCGGTGCACGGCAAACTGCAGGAGGCCTTCACCAAGATCATGCACCAG AGTTCCGGCTGGGAGCGCGTGTTCGGGACGTATTTCCGCGTGGGCTTCTACGGCGCCCAC TTCGGTGACCTGGATGAGCAGGAGTTTGTGTACAAGGAGCCATCGATCACGAAGCTGGCA GAGATCTCACACCGGCTGGAGGAGTTCTACACGGAGAGATTTGGCGACGACGTCGTTGAG ATTATCAAAGACTCTAACCCTGTGGACAAGTCCAAGCTTGACTCACAAAAGGCCTACATC CAGATCACGTATGTGGAACCGTACTTTGATACCTACGAGCTCAAGGACCGGGTGACCTAC TTTGACCGCAACTATGGGCTTCGCACATTCCTGTTCTGCACGCCGTTCACGCCGGATGGG CGCGCACACGGGGAGCTGCCCGAGCAACACAAGCGTAAGACGCTGCTCAGCACCGACCAC GCCTTCCCCTACATCAAGACTCGCATCCGTGTGTGCCACCGGGAGGAGACGGTGCTGACG CCAGTGGAGGTGGCCATCGAGGACATGCAGAAGAAGACACGGGAGCTGGCCTTTGCCACC GAGCAGGACCCACCAGATGCTAAGATGCTACAGATGGTGCTTCAGGGCTCTGTAGGGCCC ACCGTGAACCAGGGTCCCCTGGAGGTGGCCCAGGTGTTTTTAGCAGAGATCCCGGAAGAC CCCAAGCTCTTCCGGCATCACAACAAATTGCGGCTCTGCTTCAAGGACTTCTGCAAGAAA TGTGAGGATGCGCTGCGGAAAAATAAGGCCCTGATTGGGCCGGACCAGAAGGAGTACCAC CGTGAGCTGGAGCGCAACTACTGCCGCCTGCGGGAGGCTCTGCAGCCCCTGCTTACCCAG CGCCTGCCCCAGCTGATGGCACCCACCCCACCCGGCCTCAGGAACTCCTTGAACAGAGCA AGTTTCCGAAAGGCAGACCTCTGA |
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Protein Properties | |||||||||||||||
Number of Residues | 2047 | ||||||||||||||
Molecular Weight | 229555.6 | ||||||||||||||
Theoretical pI | 6.72 | ||||||||||||||
Pfam Domain Function | |||||||||||||||
Signals |
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Transmembrane Regions |
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Protein Sequence |
>Dedicator of cytokinesis protein 6 MAASERRAFAHKINRTVAAEVRKQVSRERSGSPHSSRRCSSSLGVPLTEVVEPLDFEDVL LSRPPDAEPGPLRDLVEFPADDLELLLQPRECRTTEPGIPKDEKLDAQVRAAVEMYIEDW VIVHRRYQYLSAAYSPVTTDTQRERQKGLPRQVFEQDASGDERSGPEDSNDSRRGSGSPE DTPRSSGASSIFDLRNLAADSLLPSLLERAAPEDVDRRNETLRRQHRPPALLTLYPAPDE DEAVERCSRPEPPREHFGQRILVKCLSLKFEIEIEPIFGILALYDVREKKKISENFYFDL NSDSMKGLLRAHGTHPAISTLARSAIFSVTYPSPDIFLVIKLEKVLQQGDISECCEPYMV LKEVDTAKNKEKLEKLRLAAEQFCTRLGRYRMPFAWTAVHLANIVSSAGQLDRDSDSEGE RRPAWTDRRRRGPQDRASSGDDACSFSGFRPATLTVTNFFKQEAERLSDEDLFKFLADMR RPSSLLRRLRPVTAQLKIDISPAPENPHFCLSPELLHIKPYPDPRGRPTKEILEFPAREV YAPHTSYRNLLYVYPHSLNFSSRQGSVRNLAVRVQYMTGEDPSQALPVIFGKSSCSEFTR EAFTPVVYHNKSPEFYEEFKLHLPACVTENHHLLFTFYHVSCQPRPGTALETPVGFTWIP LLQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDGHKGVFSVELTAVSSVHPQ DPYLDKFFTLVHVLEEGAFPFRLKDTVLSEGNVEQELRASLAALRLASPEPLVAFSHHVL DKLVRLVIRPPIISGQIVNLGRGAFEAMAHVVSLVHRSLEAAQDARGHCPQLAAYVHYAF RLPGTEPSLPDGAPPVTVQAATLARGSGRPASLYLARSKSISSSNPDLAVAPGSVDDEVS RILASKLLHEELALQWVVSSSAVREAILQHAWFFFQLMVKSMALHLLLGQRLDTPRKLRF PGRFLDDITALVGSVGLEVITRVHKDVELAEHLNASLAFFLSDLLSLVDRGFVFSLVRAH YKQVATRLQSSPNPAALLTLRMEFTRILCSHEHYVTLNLPCCPLSPPASPSPSVSSTTSQ SSTFSSQAPDPKVTSMFELSGPFRQQHFLAGLLLTELALALEPEAEGAFLLHKKAISAVH SLLCGHDTDPRYAEATVKARVAELYLPLLSIARDTLPRLHDFAEGPGQRSRLASMLDSDT EGEGDIAGTINPSVAMAIAGGPLAPGSRASISQGPPTASRAGCALSAESSRTLLACVLWV LKNTEPALLQRWATDLTLPQLGRLLDLLYLCLAAFEYKGKKAFERINSLTFKKSLDMKAR LEEAILGTIGARQEMVRRSRERSPFGNPENVRWRKSVTHWKQTSDRVDKTKDEMEHEALV EGNLATEASLVVLDTLEIIVQTVMLSEARESVLGAVLKVVLYSLGSAQSALFLQHGLATQ RALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRTHASASLYLLMRQNFEIGHNFA RVKMQVTMSLSSLVGTTQNFSEEHLRRSLKTILTYAEEDMGLRDSTFAEQVQDLMFNLHM ILTDTVKMKEHQEDPEMLIDLMYRIARGYQGSPDLRLTWLQNMAGKHAELGNHAEAAQCM VHAAALVAEYLALLEDHRHLPVGCVSFQNISSNVLEESAISDDILSPDEEGFCSGKHFTE LGLVGLLEQAAGYFTMGGLYEAVNEVYKNLIPILEAHRDYKKLAAVHGKLQEAFTKIMHQ SSGWERVFGTYFRVGFYGAHFGDLDEQEFVYKEPSITKLAEISHRLEEFYTERFGDDVVE IIKDSNPVDKSKLDSQKAYIQITYVEPYFDTYELKDRVTYFDRNYGLRTFLFCTPFTPDG RAHGELPEQHKRKTLLSTDHAFPYIKTRIRVCHREETVLTPVEVAIEDMQKKTRELAFAT EQDPPDAKMLQMVLQGSVGPTVNQGPLEVAQVFLAEIPEDPKLFRHHNKLRLCFKDFCKK CEDALRKNKALIGPDQKEYHRELERNYCRLREALQPLLTQRLPQLMAPTPPGLRNSLNRA SFRKADL |
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External Links | |||||||||||||||
GenBank ID Protein | 157426887 | ||||||||||||||
UniProtKB/Swiss-Prot ID | Q96HP0 | ||||||||||||||
UniProtKB/Swiss-Prot Entry Name | DOCK6_HUMAN | ||||||||||||||
PDB IDs | Not Available | ||||||||||||||
GenBank Gene ID | NM_020812.2 | ||||||||||||||
GeneCard ID | DOCK6 | ||||||||||||||
GenAtlas ID | DOCK6 | ||||||||||||||
HGNC ID | HGNC:19189 | ||||||||||||||
References | |||||||||||||||
General References |
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