Hmdb loader
Identification
HMDB Protein ID HMDBP08097
Secondary Accession Numbers
  • 13808
Name Urotensin-2 receptor
Synonyms
  1. G-protein coupled receptor 14
  2. UR-2-R
  3. UR-II-R
  4. Urotensin II receptor
Gene Name UTS2R
Protein Type Unknown
Biological Properties
General Function Involved in G-protein coupled receptor protein signaling pathway
Specific Function High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
receptor activity
urotensin ii receptor activity
molecular transducer activity
signal transducer activity
peptide receptor activity
peptide receptor activity, g-protein coupled
Process
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 17q25.3
SNPs UTS2R
Gene Sequence
>1170 bp
ATGGCGCTGACCCCCGAGTCCCCGAGCAGCTTCCCTGGGCTGGCCGCCACCGGCAGCTCT
GTGCCGGAGCCGCCTGGCGGCCCCAACGCAACCCTCAACAGCTCCTGGGCCAGCCCGACC
GAGCCCAGCTCCCTGGAGGACCTGGTGGCCACGGGCACCATTGGGACTCTGCTGTCGGCC
ATGGGCGTGGTGGGCGTGGTGGGCAACGCCTACACGCTGGTGGTCACCTGCCGCTCCCTG
CGTGCGGTGGCCTCCATGTACGTCTACGTGGTCAACCTGGCGCTGGCCGACCTGCTGTAC
CTGCTCAGCATCCCCTTCATCGTGGCCACCTACGTCACCAAGGAGTGGCACTTCGGGGAC
GTGGGCTGCCGCGTGCTCTTCGGCCTGGACTTCCTGACCATGCACGCCAGCATCTTCACG
CTGACCGTCATGAGCAGCGAGCGCTACGCTGCGGTGCTGCGGCCGCTGGACACCGTGCAG
CGCCCCAAGGGCTACCGCAAGCTGCTGGCGCTGGGCACCTGGCTGCTGGCGCTGCTGCTG
ACGCTGCCCGTGATGCTGGCCATGCGGCTGGTGCGCCGGGGTCCCAAGAGCCTGTGCCTG
CCCGCCTGGGGCCCGCGCGCCCACCGCGCCTACCTGACGCTGCTCTTCGCCACCAGCATC
GCGGGGCCCGGGCTGCTCATCGGGCTGCTCTACGCGCGCCTGGCCCGCGCCTACCGCCGC
TCGCAGCGCGCCTCCTTCAAGCGGGCCCGGCGGCCGGGGGCGCGCGCGCTGCGCCTGGTG
CTGGGCATCGTGCTGCTCTTCTGGGCCTGCTTCCTGCCCTTCTGGCTGTGGCAGCTGCTC
GCCCAGTACCACCAGGCCCCGCTGGCGCCGCGGACGGCGCGCATCGTCAACTACCTGACC
ACCTGCCTCACCTACGGCAACAGCTGCGCCAACCCCTTCCTCTACACGCTGCTCACCAGG
AACTACCGCGACCACCTGCGCGGCCGCGTGCGGGGCCCGGGCAGCGGGGGAGGCCGGGGG
CCCGTTCCCTCCCTGCAGCCCCGCGCCCGCTTCCAGCGCTGTTCGGGCCGCTCCCTGTCT
TCCTGCAGCCCACAGCCCACTGACAGCCTCGTGCTGGCCCCAGCGGCCCCGGCCCGACCT
GCGCCCGAGGGTCCCAGGGCCCCGGCGTGA
Protein Properties
Number of Residues 389
Molecular Weight 42129.9
Theoretical pI 11.06
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 55-77
  • 88-113
  • 125-146
  • 168-186
  • 210-232
  • 259-284
  • 298-318
Protein Sequence
>Urotensin-2 receptor
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
GenBank ID Protein 5902616
UniProtKB/Swiss-Prot ID Q9UKP6
UniProtKB/Swiss-Prot Entry Name UR2R_HUMAN
PDB IDs Not Available
GenBank Gene ID AF140631
GeneCard ID UTS2R
GenAtlas ID UTS2R
HGNC ID HGNC:4468
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  3. Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Disa J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Ohlstein EH, Bergsma DJ, Douglas SA: Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6. [PubMed:10499587 ]
  4. Sugo T, Murakami Y, Shimomura Y, Harada M, Abe M, Ishibashi Y, Kitada C, Miyajima N, Suzuki N, Mori M, Fujino M: Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. Biochem Biophys Res Commun. 2003 Oct 24;310(3):860-8. [PubMed:14550283 ]