Hmdb loader
Identification
HMDB Protein ID HMDBP07967
Secondary Accession Numbers
  • 13678
Name Lithostathine-1-beta
Synonyms
  1. PSP-2
  2. Pancreatic stone protein 2
  3. REG-1-beta
  4. Regenerating islet-derived protein 1-beta
  5. Regenerating protein I beta
Gene Name REG1B
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:2
Locus 2p12
SNPs REG1B
Gene Sequence
>501 bp
ATGGCTCAGACCAACTCGTTCTTCATGCTGATCTCCTCCCTGATGTTCCTGTCTCTGAGC
CAAGGCCAGGAGTCCCAGACAGAGCTGCCTAATCCCCGAATCAGCTGCCCAGAAGGCACC
AATGCCTATCGCTCCTACTGCTACTACTTTAATGAAGACCCTGAGACCTGGGTTGATGCA
GATCTCTATTGCCAGAACATGAATTCAGGCAACCTGGTGTCTGTGCTCACCCAGGCGGAG
GGTGCCTTCGTGGCCTCACTGATTAAGGAGAGTAGCACTGATGACAGCAATGTCTGGATT
GGCCTCCATGACCCAAAAAAGAACCGCCGCTGGCACTGGAGTAGTGGGTCCCTGGTCTCC
TACAAGTCCTGGGACACTGGATCCCCGAGCAGTGCTAATGCTGGCTACTGTGCAAGCCTG
ACTTCATGCTCAGGATTCAAGAAATGGAAGGATGAATCTTGTGAGAAGAAGTTCTCCTTT
GTTTGCAAGTTCAAAAACTAG
Protein Properties
Number of Residues 166
Molecular Weight 18664.6
Theoretical pI 5.75
Pfam Domain Function
Signals
  • 1-22
Transmembrane Regions
  • None
Protein Sequence
>Lithostathine-1-beta
MAQTNSFFMLISSLMFLSLSQGQESQTELPNPRISCPEGTNAYRSYCYYFNEDPETWVDA
DLYCQNMNSGNLVSVLTQAEGAFVASLIKESSTDDSNVWIGLHDPKKNRRWHWSSGSLVS
YKSWDTGSPSSANAGYCASLTSCSGFKKWKDESCEKKFSFVCKFKN
GenBank ID Protein 20381230
UniProtKB/Swiss-Prot ID P48304
UniProtKB/Swiss-Prot Entry Name REG1B_HUMAN
PDB IDs Not Available
GenBank Gene ID BC027895
GeneCard ID REG1B
GenAtlas ID REG1B
HGNC ID HGNC:9952
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Bartoli C, Gharib B, Giorgi D, Sansonetti A, Dagorn JC, Berge-Lefranc JL: A gene homologous to the reg gene is expressed in the human pancreas. FEBS Lett. 1993 Aug 2;327(3):289-93. [PubMed:8348956 ]
  3. Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H, Okamoto H: Isolation, structural determination and expression of a novel reg gene, human regI beta. Biochim Biophys Acta. 1994 Mar 1;1217(2):199-202. [PubMed:8110835 ]
  4. De Reggi M, Capon C, Gharib B, Wieruszeski JM, Michel R, Fournet B: The glycan moiety of human pancreatic lithostathine. Structure characterization and possible pathophysiological implications. Eur J Biochem. 1995 Jun 1;230(2):503-10. [PubMed:7607222 ]