Hmdb loader
Identification
HMDB Protein ID HMDBP07881
Secondary Accession Numbers
  • 13592
Name Protocadherin alpha-4
Synonyms
  1. PCDH-alpha-4
Gene Name PCDHA4
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31
SNPs PCDHA4
Gene Sequence
>2844 bp
ATGGAGTTTTCCTGGGGAAGCGGCCAGGAATCCCGGCGTCTGCTGCTCTTACTTCTTCTC
CTCGCAGCCTGGGAGGCAGGGAACGGTCAGCTCCACTACTCGGTCTCCGAGGAGGCCAAA
CACGGCACCTTCGTGGGCCGCATCGCGCAGGACCTGGGACTGGAGCTGGCGGAGCTGGTG
CCGCGCCTGTTCCGGGTGGCGTCCAAGGGCCGCGGAGGCCTTCTGGAGGTAAATCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATCGACCGGGAGGAGCTGTGCCGGCGGAGCGCG
GAGTGCAGCATCCACCTGGAGGTGATCGTAGACAGGCCGCTGCAGGTTTTCCATGTGGAC
GTGGAGGTGAGGGACATTAACGATAACCCGCCGGTGTTCCCAGCAACACAAAAGAACCTG
TCCATCGCGGAATCCAGGCCGCTTGACTCTCGGTTTCCACTAGAGGGCGCCTCGGATGCA
GATATCGGGGAGAACGCCCTGCTCACTTACAGACTGAGCCCAAATGAATACTTTTCTCTG
GAAAAACCACCTGATGACGAGCTGGTAAAAGGTCTTGGGCTTATATTACGGAAATCTTTA
GACAGAGAAGAAGCTCCGGAGATTTTTTTAGTGCTCACAGCCACTGATGGAGGCAAACCC
GAGTTGACTGGCACCGTTCAGTTACTCATCACAGTACTGGATGCCAATGACAATGCCCCA
GCTTTTGACAGAACCATTTATAAGGTGAGATTACTAGAAAATGTTCCTAATGGAACATTG
GTAATTAAACTTAACGCCTCAGATTTAGACGAAGGATTGAATGGGGACATTGTTTATTCA
TTCTCAAATGATATTTCGCCAAATGTGAAATCCAAGTTTCACATAGATCCAATTACTGGA
CAAATTATTGTAAAGGGATATATTGACTTTGAAGAAAGCAAATCCTATGAAATTATTGTA
GAGGGCATTGATAAGGGACAGCTCCCACTTTCTGGCCATTGTAGAGTTATTGTGGAAGTA
GAAGACAACAACGATAATGTCCCAGATTTGGAATTCAAGTCTTTATCACTTCCAATTAGA
GAGGACGCTCCACTGGGTACAGTCATCGCCCTGATCAGCGTGTCCGACAAAGACATGGGT
GTCAATGGGCTGGTCACCTGCTCCTTGACGTCCCACGTCCCCTTCAAGCTGGTGTCCACC
TTCAAGAATTACTACTCGTTGGTGCTGGACAGTGCCCTGGACCGCGAGAGCGTGTCAGCC
TATGAGCTGGTGGTGACCGCGCGAGACGGGGGCTCGCCTTCGCTGTGGGCCACGGCCAGT
GTTTCTGTGGAGGTGGCTGATGTGAACGACAACGCTCCGGCGTTCGCGCAGCCCGAGTAC
ACAGTGTTCGTGAAGGAGAACAACCCGCCGGGCTGCCACATCTTCACTGTGTCTGCGTGG
GACGCGGACGCGCAGGAGAACGCGCTGGTGTCCTACTCGCTGGTAGAGCGGCGGGTAGGG
GAGCGCGCGCTGTCGAGCTACGTTTCGGTGCATGCGGAGAGCGGCAAGGTGTACGCGCTG
CAGCCGCTGGACCACGAGGAGCTAGAGCTGCTGCAGTTTCAGGTGACCGCTCGCGATGCC
GGCGTGCCACCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAAAACGAC
AACGCGCCAGCACTGCTAGCGCCTCGGGCGGGTGGCACTGGTGGCGCAGTGAGCGAGCTG
GTGCCATGGTCGGTGGGTGTGGGCCACGTGGTGGCAAAGGTGCGCGCGGTGGATGCTGAC
TCGGGCTACAACGCGTGGCTTTCGTACGAGCTGCAGCCGGGGACTGGTGGCGCGCGCATC
CCGTTCCGCGTGGGGCTGTACACTGGCGAGATCAGCACAACGCGTGCCCTGGACGAAACG
GACGCTCCGCGCCACCGCCTACTGGTACTGGTGAAGGACCACGGCGAGCCCGCGCTGACG
GCCACGGCCACTGTGCTGGTGTCACTTGTGGAGAGTGGACAGGCGCCAAAGGCCTCCTCA
CGGGCGTTGGTGGGCGCTGTGGGTCCCGATGCTGCGCTGGTGGATGTCAACGTATACCTG
ATCATTGCCATCTGCGCGGTGTCCAGCCTTTTGGTGCTCACGCTGCTGCTGTACACCGCG
CTGCGGTGCTCTGCGCTGCCCACCGAGGGCGCGTGCGCTCCGGGCAAGCCCACGCTGGTG
TGCTCCAGTGCGGTGGGGAGCTGGTCATACTCGCAGCAGAGGAGGCCGAGGGTGTGCTCT
GGTGAGGGCCCACCCAAGACCGACCTCATGGCCTTCAGCCCCAGTTTACCTGACTCTAGG
GACAGAGAAGATCAGCTGCAGACAACTGAGGAATCCTTTGCAAAGCCACGACAGCCCAAC
CCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTGCACCTAGAG
GAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCAACAGTATCC
AGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTCAAC
AGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGTCCCGGTGAG
TTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGGCAGGAGCCT
ACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAGGAGACCAAG
AAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAAGGGAACAGC
ACGACTGACAACAGTGACCAGTGA
Protein Properties
Number of Residues 947
Molecular Weight 102292.3
Theoretical pI 4.71
Pfam Domain Function
Signals
  • 1-29
Transmembrane Regions
  • 698-718
Protein Sequence
>Protocadherin alpha-4
MEFSWGSGQESRRLLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV
PRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVD
VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL
EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP
AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG
QIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIR
EDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSA
YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW
DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDA
GVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDAD
SGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALT
ATATVLVSLVESGQAPKASSRALVGAVGPDAALVDVNVYLIIAICAVSSLLVLTLLLYTA
LRCSALPTEGACAPGKPTLVCSSAVGSWSYSQQRRPRVCSGEGPPKTDLMAFSPSLPDSR
DREDQLQTTEESFAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVS
SATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEP
TNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
GenBank ID Protein 9256588
UniProtKB/Swiss-Prot ID Q9UN74
UniProtKB/Swiss-Prot Entry Name PCDA4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_018907.2
GeneCard ID PCDHA4
GenAtlas ID PCDHA4
HGNC ID HGNC:8670
References
General References
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  2. Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. [PubMed:15372022 ]
  3. Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]