Hmdb loader
Identification
HMDB Protein ID HMDBP07790
Secondary Accession Numbers
  • 13499
Name Multiple C2 and transmembrane domain-containing protein 1
Synonyms Not Available
Gene Name MCTP1
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Not Available
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Gene Properties
Chromosome Location Chromosome:5
Locus 5q15
SNPs MCTP1
Gene Sequence
>3000 bp
ATGGAGCCCCGGGCTGCCGCGGCGGGCGAGCCAGAGCCGCCGGCGGCGTCCTCCTCCTTC
CAGGCCCGGCTCTGGAAGAACCTGCAGCTGGGGGTGGGCAGGAGCAAGGGCGGCGGGGGC
GGGCGCGCTGGGGGTCCAGAGCGCCGCACTGCGGACACCCCGTCGCCCTCCCCGCCACCC
CCGGTGGGCACAGGGAATGCACCGGCCAGGGGGAGTGGTGCAGGCAGCAGGTGGAGCGGC
TTCAAGAAGCGGAAGCAAGTGCTGGACCGAGTCTTCTCCTCCTCGCAGCCCAACCTGTGC
TGCTCGTCGCCGGAGCCCCTGGAGCCCGGCGGCGCCGGCAGAGCCGAGCAGGGGTCCACG
CTACGCCGCCGGATCCGCGAGCATTTGCTCCCCGCCGTAAAGGGGCCCGCGGCGGCCTCG
GGAGCAGCGGGAGGGACGCCTCCTGGCGGACGCTCCCCCGACTCAGCTCCTTCCTCTTCC
TCCGCCTCATCCTCCCTGTCCTCCTCGCCCCAGCCTCCCCCGAGGGGGGACCGCGCCCGA
GATGAGGGTGCACGGCGTCAGGGCCCCGGGGCGCACTTGTGCCACCAGAAGAGCTCCTCT
CTGCCGGGCACCGCCTGCCTGGAGCAGCTGCTGGAGCCGCCGCCTCCTCCCGCAGAGCCG
GCGCGGAGTCCCGCGGAGTCTCGGGCCCCGGAGACGGGCGAGGAGCACGGCAGCAGCCAG
AAAATAATAAACACTGCTGGAACCAGTAATGCAGAAGTCCCCTTGGCTGATCCCGGAATG
TACCAGCTGGACATTACATTAAGAAGGGGTCAAAGTTTAGCTGCTCGAGATCGAGGAGGG
ACGAGTGATCCATATGTGAAGTTTAAAATCGGAGGAAAAGAAGTTTTTAGAAGTAAGATA
ATACACAAGAACCTCAACCCTGTGTGGGAAGAAAAAGCTTGTATTCTGGTTGATCATCTT
AGGGAGCCATTGTATATAAAGGTATTTGACTATGATTTTGGACTACAGGATGACTTTATG
GGCTCAGCCTTTCTGGATCTGACACAATTGGAGTTAAACAGGCCCACAGATGTGACCCTT
ACTCTGAAAGATCCTCATTATCCTGACCATGATCTTGGAATCATTTTGCTCTCAGTCATC
CTTACCCCTAAAGAAGGAGAGTCCAGGGATGTGACAATGCTAATGAGGAAGAGTTGGAAA
AGATCAAGTAAGGAACTTTCAGAAAATGAAGTGGTTGGATCTTATTTCTCTGTGAAGTCT
CTCTTTTGGAGGACGTGCGGCAGGCCAGCTCTTCCTGTCCTGGGCTTCTGCAGAGCAGAG
CTTCAGAATCCTTATTGCAAAAATGTACAATTTCAGACCCAAAGTTTACGCCTATCAGAC
CTACACAGAAAATCGCATCTTTGGAGAGGAATAGTCAGCATCACCTTGATTGAAGGGAGA
GACCTCAAGGCCATGGATTCCAACGGGTTGAGCGATCCCTACGTGAAGTTCCGGCTTGGG
CATCAGAAGTACAAGAGCAAGATTATGCCAAAAACGTTGAATCCTCAGTGGAGGGAACAA
TTTGATTTTCACCTTTATGAAGAAAGAGGAGGAGTCATTGATATCACTGCATGGGACAAA
GATGCTGGGAAAAGGGATGATTTCATTGGCAGGTGCCAGGTCGACCTGTCAGCCCTCAGT
AGGGAACAGACGCACAAGCTGGAGTTGCAGCTGGAAGAGGGTGAGGGACACCTGGTGCTG
CTGGTCACTCTGACAGCATCAGCCACAGTCAGCATCTCTGACCTGTCTGTCAACTCCCTG
GAGGACCAGAAGGAACGAGAGGAGATATTAAAGAGATATAGCCCATTGAGGATATTTCAC
AACCTGAAAGATGTGGGATTTCTCCAGGTGAAAGTCATCAGAGCGGAAGGGTTAATGGCT
GCCGACGTCACTGGAAAAAGTGACCCATTTTGTGTGGTAGAACTGAACAACGATAGACTG
CTAACACATACTGTCTACAAAAATCTCAATCCTGAGTGGAATAAAGTCTTCACGTTCAAC
ATTAAAGATATCCATTCAGTTCTTGAAGTGACAGTTTATGATGAAGATCGGGATCGAAGT
GCTGACTTTCTGGGCAAAGTTGCTATACCATTGCTGTCTATTCAAAATGGTGAACAGAAA
GCCTACGTCTTGAAAAACAAGCAGCTGACAGGGCCAACAAAGGGGGTCATCTATCTTGAA
ATAGATGTGATTTTTAATGCTGTGAAAGCCAGCTTACGAACATTAATACCCAAAGAACAG
AAGTACATTGAAGAGGAAAACAGACTCTCTAAACAGCTGCTACTAAGAAACTTTATCAGA
ATGAAACGTTGTGTCATGGTGCTGGTAAATGCTGCATACTACGTTAATAGTTGCTTTGAT
TGGGATTCACCCCCAAGGAGTCTCGCTGCTTTTGTGCTCTTTCTCTTTGTTGTCTGGAAC
TTTGAGCTCTACATGATACCACTGGTTTTGTTGTTACTATTGACATGGAACTACTTCTTG
ATAATATCAGGGAAAGATAACAGGCAACGTGATACAGTAGTGGAGGACATGCTAGAGGAC
GAGGAAGAAGAAGATGACAAAGATGACAAGGACAGTGAAAAAAAGGGATTTATAAATAAA
ATCTATGCCATCCAGGAGGTATGTGTCAGTGTCCAGAACATCCTAGATGAAGTGGCTTCC
TTTGGCGAAAGGATAAAGAATACTTTCAACTGGACTGTCCCATTCTTAAGCTGGCTGGCC
ATTGTAGCCCTCTGTGTGTTCACAGCCATCCTGTACTGCATTCCGCTGAGATACATTGTC
CTTGTCTGGGGCATCAATAAATTTACAAAAAAGCTTCGGAGTCCATATGCAATTGATAAC
AATGAACTACTTGACTTCCTTTCCAGAGTCCCTTCAGATGTACAAGTGGTGCAATACCAA
GAACTGAAACCAGATCCTTCTCATAGCCCATATAAAAGAAAGAAAAACAATCTTGGCTAG
Protein Properties
Number of Residues 999
Molecular Weight 111623.2
Theoretical pI 8.26
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 811-831
  • 914-934
Protein Sequence
>Multiple C2 and transmembrane domain-containing protein 1
MEPRAAAAGEPEPPAASSSFQARLWKNLQLGVGRSKGGGGGRAGGPERRTADTPSPSPPP
PVGTGNAPARGSGAGSRWSGFKKRKQVLDRVFSSSQPNLCCSSPEPLEPGGAGRAEQGST
LRRRIREHLLPAVKGPAAASGAAGGTPPGGRSPDSAPSSSSASSSLSSSPQPPPRGDRAR
DEGARRQGPGAHLCHQKSSSLPGTACLEQLLEPPPPPAEPARSPAESRAPETGEEHGSSQ
KIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKI
IHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTL
TLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKS
LFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGR
DLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDK
DAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSL
EDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRL
LTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK
AYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIR
MKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFL
IISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEVAS
FGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAIDN
NELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG
GenBank ID Protein 205361109
UniProtKB/Swiss-Prot ID Q6DN14
UniProtKB/Swiss-Prot Entry Name MCTP1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_024717.4
GeneCard ID MCTP1
GenAtlas ID MCTP1
HGNC ID HGNC:26183
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. [PubMed:15372022 ]
  4. Shin OH, Han W, Wang Y, Sudhof TC: Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties. J Biol Chem. 2005 Jan 14;280(2):1641-51. Epub 2004 Nov 4. [PubMed:15528213 ]