Showing Protein Latrophilin-2 (HMDBP07784)
Identification | |||||||||||||||||||
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HMDB Protein ID | HMDBP07784 | ||||||||||||||||||
Secondary Accession Numbers |
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Name | Latrophilin-2 | ||||||||||||||||||
Synonyms |
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Gene Name | LPHN2 | ||||||||||||||||||
Protein Type | Unknown | ||||||||||||||||||
Biological Properties | |||||||||||||||||||
General Function | Involved in transmembrane receptor activity | ||||||||||||||||||
Specific Function | Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis | ||||||||||||||||||
Pathways | Not Available | ||||||||||||||||||
Reactions | Not Available | ||||||||||||||||||
GO Classification |
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Cellular Location |
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Gene Properties | |||||||||||||||||||
Chromosome Location | Chromosome:1 | ||||||||||||||||||
Locus | 1p31.1 | ||||||||||||||||||
SNPs | LPHN2 | ||||||||||||||||||
Gene Sequence |
>4212 bp ATGGTGTCTTCTGGTTGCAGAATGCGAAGTCTGTGGTTTATCATTGTAATCAGCTTCTTA CCAAATACAGAAGGTTTCAGCAGAGCAGCTTTACCATTTGGGCTGGTGAGGCGAGAATTA TCCTGTGAAGGTTATTCTATAGATCTGCGATGCCCGGGCAGTGATGTCATCATGATTGAG AGCGCTAACTATGGTCGGACGGATGACAAGATTTGTGATGCTGACCCATTTCAGATGGAG AATACAGACTGCTACCTCCCCGATGCCTTCAAAATTATGACTCAAAGGTGCAACAATCGA ACACAGTGTATAGTAGTTACTGGGTCAGATGTGTTTCCTGATCCATGTCCTGGAACATAC AAATACCTTGAAGTCCAATATGAATGTGTCCCTTACATTTTTGTGTGTCCTGGGACCTTG AAAGCAATTGTGGACTCACCATGTATATATGAAGCTGAACAAAAGGCGGGTGCTTGGTGC AAGGACCCTCTTCAGGCTGCAGATAAAATTTATTTCATGCCCTGGACTCCCTATCGTACC GATACTTTAATAGAATATGCTTCTTTAGAAGATTTCCAAAATAGTCGCCAAACAACAACA TATAAACTTCCAAATCGAGTAGATGGTACTGGATTTGTGGTGTATGATGGTGCTGTCTTC TTTAACAAAGAAAGAACGAGGAATATTGTGAAATTTGACTTGAGGACTAGAATTAAGAGT GGCGAGGCCATAATTAACTATGCCAACTACCATGATACCTCACCATACAGATGGGGAGGA AAGACTGATATCGACCTAGCAGTTGATGAAAATGGTTTATGGGTCATTTACGCCACTGAA CAGAACAATGGAATGATAGTTATTAGCCAGCTGAATCCATACACTCTTCGATTTGAAGCA ACGTGGGAGACTGTATACGACAAACGTGCCGCATCAAATGCTTTTATGATATGCGGAGTC CTCTATGTGGTTAGGTCAGTTTATCAAGACAATGAAAGTGAAACAGGCAAGAACTCAATT GATTACATTTATAATACCCGATTAAACCGAGGAGAATATGTAGATGTTCCCTTCCCCAAC CAGTATCAGTATATTGCTGCAGTGGATTACAATCCAAGAGATAACCAACTTTACGTGTGG AACAATAACTTCATTTTACGATATTCTCTGGAGTTTGGTCCACCTGATCCTGCCCAAGTG CCTACCACAGCTGTGACAATAACTTCTTCAGCTGAGCTGTTCAAAACCATAATATCAACC ACAAGCACTACTTCACAGAAAGGCCCCATGAGCACAACTGTAGCTGGATCACAGGAAGGA AGCAAAGGGACAAAACCACCTCCAGCAGTTTCTACAACCAAAATTCCACCTATAACAAAT ATTTTTCCCCTGCCAGAGAGATTCTGTGAAGCATTAGACTCCAAGGGGATAAAGTGGCCT CAGACACAAAGGGGAATGATGGTTGAACGACCATGCCCTAAGGGAACAAGAGGAACTGCC TCATATCTCTGCATGATTTCCACTGGAACATGGAACCCTAAGGGCCCCGATCTTAGCAAC TGTACCTCACACTGGGTGAATCAGCTGGCTCAGAAGATCAGAAGCGGAGAAAATGCTGCT AGTCTTGCCAATGAACTGGCTAAACATACCAAAGGGCCAGTGTTTGCTGGGGATGTAAGT TCTTCAGTGAGATTGATGGAGCAGTTGGTGGACATCCTTGATGCACAGCTGCAGGAACTG AAACCTAGTGAAAAAGATTCAGCTGGACGGAGTTATAACAAGGCAATTGTTGACACAGTG GACAACCTTCTGAGACCTGAAGCTTTGGAATCATGGAAACATATGAATTCTTCTGAACAA GCACATACTGCAACAATGTTACTCGATACATTGGAAGAAGGAGCTTTTGTCCTAGCTGAC AATCTTTTAGAACCAACAAGGGTCTCAATGCCCACAGAAAATATTGTCCTGGAAGTTGCC GTACTCAGTACAGAAGGACAGATCCAAGACTTTAAATTTCCTCTGGGCATCAAAGGAGCA GGCAGCTCAATCCAACTGTCCGCAAATACCGTCAAACAGAACAGCAGGAATGGGCTTGCA AAGTTGGTGTTCATCATTTACCGGAGCCTGGGACAGTTCCTTAGTACAGAAAATGCAACC ATTAAACTGGGTGCTGATTTTATTGGTCGTAATAGCACCATTGCAGTGAACTCTCACGTC ATTTCAGTTTCAATCAATAAAGAGTCCAGCCGAGTATACCTGACTGATCCTGTGCTTTTT ACCCTGCCACACATTGATCCTGACAATTATTTCAATGCAAACTGCTCCTTCTGGAACTAC TCAGAGAGAACTATGATGGGATATTGGTCTACCCAGGGCTGCAAGCTGGTTGACACTAAT AAAACTCGAACAACGTGTGCATGCAGCCACCTAACCAATTTTGCAATTCTCATGGCCCAC AGGGAAATTGCATATAAAGATGGCGTTCATGAATTACTTCTTACAGTCATCACCTGGGTG GGAATTGTCATTTCCCTTGTTTGCCTGGCTATCTGCATCTTCACCTTCTGCTTTTTCCGT GGCCTACAGAGTGACCGAAATACTATTCACAAGAACCTTTGTATCAACCTTTTCATTGCT GAATTTATTTTCCTAATAGGCATTGATAAGACAAAATATGCGATTGCATGCCCAATATTT GCAGGACTTCTACACTTTTTCTTTTTGGCAGCTTTTGCTTGGATGTGCCTAGAAGGTGTG CAGCTCTACCTAATGTTAGTTGAAGTTTTTGAAAGTGAATATTCAAGGAAAAAATATTAC TATGTTGCTGGTTACTTGTTTCCTGCCACAGTGGTTGGAGTTTCAGCTGCTATTGACTAT AAGAGCTATGGAACAGAAAAAGCTTGCTGGCTTCATGTTGATAACTACTTTATATGGAGC TTCATTGGACCTGTTACCTTCATTATTCTGCTAAATATTATCTTCTTGGTGATCACATTG TGCAAAATGGTGAAGCATTCAAACACTTTGAAACCAGATTCTAGCAGGTTGGAAAACATT AAGTCTTGGGTGCTTGGCGCTTTCGCTCTTCTGTGTCTTCTTGGCCTCACCTGGTCCTTT GGGTTGCTTTTTATTAATGAGGAGACTATTGTGATGGCATATCTCTTCACTATATTTAAT GCTTTCCAGGGAGTGTTCATTTTCATCTTTCACTGTGCTCTCCAAAAGAAAGTACGAAAA GAATATGGCAAGTGCTTCAGACACTCATACTGCTGTGGAGGCCTCCCAACTGAGAGTCCC CACAGTTCAGTGAAGGCATCAACCACCAGAACCAGTGCTCGCTATTCCTCTGGCACACAG AGTCGTATAAGAAGAATGTGGAATGATACTGTGAGAAAACAATCAGAATCTTCTTTTATC TCAGGTGACATCAATAGCACTTCAACACTTAATCAAGGACATTCACTGAACAATGCCAGG GATACAAGTGCCATGGATACTCTACCGCTAAATGGTAATTTTAACAACAGCTACTCGCTG CACAAGGGTGACTATAATGACAGCGTGCAAGTTGTGGACTGTGGACTAAGTCTGAATGAT ACTGCTTTTGAGAAAATGATCATTTCAGAATTAGTGCACAACAACTTACGGGGCAGCAGC AAGACTCACAACCTCGAGCTCACGCTACCAGTCAAACCTGTGATTGGAGGTAGCAGCAGT GAAGATGATGCTATTGTGGCAGATGCTTCATCTTTAATGCACAGCGACAACCCAGGGCTG GAGCTCCATCACAAAGAACTCGAGGCACCACTTATTCCTCAGCGGACTCACTCCCTTCTG TACCAACCCCAGAAGAAAGTGAAGTCCGAGGGAACTGACAGCTATGTCTCCCAACTGACA GCAGAGGCTGAAGATCACCTACAGTCCCCCAACAGAGACTCTCTTTATACAAGCATGCCC AATCTTAGAGACTCTCCCTATCCGGAGAGCAGCCCTGACATGGAAGAAGACCTCTCTCCC TCCAGGAGGAGTGAGAATGAGGACATTTACTATAAAAGCATGCCAAATCTTGGAGCTGGC CATCAGCTTCAGATGTGCTACCAGATCAGCAGGGGCAATAGTGATGGTTATATAATCCCC ATTAACAAAGAAGGGTGTATTCCAGAAGGAGATGTTAGAGAAGGACAAATGCAGCTGGTT ACAAGTCTTTAA |
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Protein Properties | |||||||||||||||||||
Number of Residues | 1459 | ||||||||||||||||||
Molecular Weight | 163347.4 | ||||||||||||||||||
Theoretical pI | 6.39 | ||||||||||||||||||
Pfam Domain Function | |||||||||||||||||||
Signals |
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Transmembrane Regions |
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Protein Sequence |
>Latrophilin-2 MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIE SANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTY KYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRT DTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKS GEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEA TWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPN QYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIIST TSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWP QTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAA SLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREK TCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTR VSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIY RSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDP DNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKD GVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIG IDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLF PATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHS NTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFI FIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMW NDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAP SAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFE KMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHH KELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRD SPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKE GCIPEGDVREGQMQLVTSL |
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External Links | |||||||||||||||||||
GenBank ID Protein | 6912464 | ||||||||||||||||||
UniProtKB/Swiss-Prot ID | O95490 | ||||||||||||||||||
UniProtKB/Swiss-Prot Entry Name | LPHN2_HUMAN | ||||||||||||||||||
PDB IDs | Not Available | ||||||||||||||||||
GenBank Gene ID | NM_012302 | ||||||||||||||||||
GeneCard ID | LPHN2 | ||||||||||||||||||
GenAtlas ID | LPHN2 | ||||||||||||||||||
HGNC ID | HGNC:18582 | ||||||||||||||||||
References | |||||||||||||||||||
General References |
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