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Showing Protein Double C2-like domain-containing protein alpha (HMDBP07653)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP07653
Secondary Accession Numbers
  • 13362
Name Double C2-like domain-containing protein alpha
Synonyms
  1. Doc2
  2. Doc2-alpha
Gene Name DOC2A
Protein Type Unknown
Biological Properties
General Function Involved in transporter activity
Specific Function Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells
Pathways Not Available
Reactions Not Available
GO Classification
Component
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
coated vesicle
clathrin-coated vesicle
synaptic vesicle
membrane
cell part
organelle
vesicle
Function
transporter activity
Process
establishment of localization
transport
Cellular Location
  1. Lysosome
  2. Cytoplasmic vesicle
  3. secretory vesicle
  4. Cell junction
  5. synapse
  6. Peripheral membrane protein (Probable)
  7. synaptosome
  8. synaptic vesicle membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 16p11.2
SNPs DOC2A
Gene Sequence 
>1203 bp
ATGAGGGGCCGCAGGGGCGATCGCATGACCATCAACATCCAGGAGCACATGGCCATCAAC
GTGTGCCCCGGGCCCATCCGGCCCATCCGCCAGATCTCTGACTACTTCCCCCGGGGACCA
GGACCTGAAGGGGGCGGCGGGGGCGGCGGGGAGGCCCCCGCCCATCTGGTCCCCCTGGCT
CTGGCCCCCCCTGCAGCCCTCCTTGGGGCCACCACGCCTGAGGATGGTGCGGAGGTGGAC
AGCTATGACTCGGATGATGCCACCGCCCTAGGCACGCTGGAGTTTGACCTTCTCTACGAC
CGGGCCTCCTGCACTCTGCACTGTAGCATCCTCAGGGCCAAGGGCCTCAAGCCCATGGAT
TTCAATGGCCTCGCCGACCCCTACGTCAAGCTGCACTTGCTGCCTGGAGCCTGTAAGGCC
AATAAGCTAAAAACGAAGACTCAGAGGAACACACTGAATCCCGTGTGGAATGAGGACCTG
ACTTACAGCGGGATCACAGATGACGACATCACGCACAAGGTGCTCAGGATCGCCGTCTGT
GATGAGGACAAGCTGAGTCACAATGAGTTTATTGGGGAGATCCGCGTGCCCCTCCGCCGC
CTCAAGCCTTCGCAGAAGAAGCATTTTAACATCTGCCTCGAGCGCCAGGTCCCGCTGGCG
TCCCCCTCTTCCATGTCAGCGGCGCTGAGGGGCATCTCCTGTTATCTGAAGGAGTTGGAG
CAGGCGGAGCAGGGGCAGGGGCTGCTGGAGGAGCGTGGCCGCATCCTGCTGAGTCTCAGC
TACAGCTCGCGGCGCCGGGGACTGCTGGTAGGCATCTTGCGCTGCGCCCATCTGGCTGCC
ATGGACGTCAACGGTTACTCGGACCCCTACGTCAAGACGTACCTGAGGCCCGATGTGGAC
AAGAAATCCAAGCATAAGACGTGTGTGAAGAAGAAGACTCTCAACCCAGAATTTAACGAG
GAGTTTTTCTACGAGATAGAGCTCTCCACTCTGGCCACCAAGACCCTGGAAGTCACCGTC
TGGGACTATGACATTGGCAAATCCAATGACTTCATTGGTGGCGTGTCCCTGGGGCCAGGT
GCCCGAGGCGAGGCTCGGAAGCACTGGAGTGACTGCCTGCAGCAGCCGGACGCAGCCCTG
GAGCGCTGGCACACCCTGACCAGTGAGCTGCCCCCTGCGGCCGGGGCTCTGTCCTCAGCC
TGA
Protein Properties
Number of Residues 400
Molecular Weight 43958.6
Theoretical pI 7.27
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Double C2-like domain-containing protein alpha
MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGGGGEAPAHLVPLA
LAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMD
FNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVC
DEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELE
QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD
KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG
ARGEARKHWSDCLQQPDAALERWHTLTSELPPAAGALSSA
GenBank ID Protein 71052058
UniProtKB/Swiss-Prot ID Q14183
UniProtKB/Swiss-Prot Entry Name DOC2A_HUMAN
PDB IDs Not Available
GenBank Gene ID BC041769
GeneCard ID DOC2A
GenAtlas ID DOC2A
HGNC ID HGNC:2985
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y: Doc2: a novel brain protein having two repeated C2-like domains. Biochem Biophys Res Commun. 1995 Jan 17;206(2):439-48. [PubMed:7826360 ]
  3. Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y: Molecular cloning of an isoform of Doc2 having two C2-like domains. Biochem Biophys Res Commun. 1995 Dec 26;217(3):1053-61. [PubMed:8554557 ]
  4. Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y: Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11418-22. [PubMed:9736751 ]
  5. Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y: Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. J Biol Chem. 1998 Nov 13;273(46):30065-8. [PubMed:9804756 ]
  6. Higashio H, Nishimura N, Ishizaki H, Miyoshi J, Orita S, Sakane A, Sasaki T: Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. J Immunol. 2008 Apr 1;180(7):4774-84. [PubMed:18354201 ]