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Showing Protein C-C motif chemokine 16 (HMDBP07571)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP07571
Secondary Accession Numbers
  • 13279
Name C-C motif chemokine 16
Synonyms
  1. Chemokine CC-4
  2. Chemokine LEC
  3. HCC-4
  4. IL-10-inducible chemokine
  5. LCC-1
  6. LMC
  7. Liver-expressed chemokine
  8. Lymphocyte and monocyte chemoattractant
  9. MTN-1
  10. Monotactin-1
  11. NCC-4
  12. Small-inducible cytokine A16
Gene Name CCL16
Protein Type Unknown
Biological Properties
General Function Involved in chemokine activity
Specific Function Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES
Pathways Not Available
Reactions Not Available
GO Classification
Component
extracellular region
Function
cytokine activity
chemokine activity
binding
protein binding
receptor binding
Process
immune system process
immune response
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:1
Locus 17q11.2
SNPs CCL16
Gene Sequence 
>363 bp
ATGAAGGTCTCCGAGGCTGCCCTGTCTCTCCTTGTCCTCATCCTTATCATTACTTCGGCT
TCTCGCAGCCAGCCAAAAGTTCCTGAGTGGGTGAACACCCCATCCACCTGCTGCCTGAAG
TATTATGAGAAAGTGTTGCCAAGGAGACTAGTGGTGGGATACAGAAAGGCCCTCAACTGT
CACCTGCCAGCAATCATCTTCGTCACCAAGAGGAACCGAGAAGTCTGCACCAACCCCAAT
GACGACTGGGTCCAAGAGTACATCAAGGATCCCAACCTACCTTTGCTGCCTACCAGGAAC
TTGTCCACGGTTAAAATTATTACAGCAAAGAATGGTCAACCCCAGCTCCTCAACTCCCAG
TGA
Protein Properties
Number of Residues 120
Molecular Weight 13599.9
Theoretical pI 10.03
Pfam Domain Function
Signals
  • 1-23
Transmembrane Regions
  • None
Protein Sequence 
>C-C motif chemokine 16
MKVSEAALSLLVLILIITSASRSQPKVPEWVNTPSTCCLKYYEKVLPRRLVVGYRKALNC
HLPAIIFVTKRNREVCTNPNDDWVQEYIKDPNLPLLPTRNLSTVKIITAKNGQPQLLNSQ
GenBank ID Protein 2723286
UniProtKB/Swiss-Prot ID O15467
UniProtKB/Swiss-Prot Entry Name CCL16_HUMAN
PDB IDs Not Available
GenBank Gene ID AB007454
GeneCard ID CCL16
GenAtlas ID CCL16
HGNC ID HGNC:10614
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Nomiyama H, Fukuda S, Iio M, Tanase S, Miura R, Yoshie O: Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. J Interferon Cytokine Res. 1999 Mar;19(3):227-34. [PubMed:10213461 ]
  3. Hedrick JA, Helms A, Vicari A, Zlotnik A: Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10. Blood. 1998 Jun 1;91(11):4242-7. [PubMed:9596672 ]
  4. Shoudai K, Hieshima K, Fukuda S, Iio M, Miura R, Imai T, Yoshie O, Nomiyama H: Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC. Biochim Biophys Acta. 1998 Mar 13;1396(3):273-7. [PubMed:9545580 ]
  5. Youn BS, Zhang S, Broxmeyer HE, Antol K, Fraser MJ Jr, Hangoc G, Kwon BS: Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochem Biophys Res Commun. 1998 Jun 18;247(2):217-22. [PubMed:9642106 ]
  6. Fukuda S, Hanano Y, Iio M, Miura R, Yoshie O, Nomiyama H: Genomic organization of the genes for human and mouse CC chemokine LEC. DNA Cell Biol. 1999 Apr;18(4):275-83. [PubMed:10235110 ]
  7. Yang JY, Spanaus KS, Widmer U: Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver. Cytokine. 2000 Feb;12(2):101-9. [PubMed:10671294 ]