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Showing Protein Signal transduction protein CBL-C (HMDBP07560)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 5 metabolites
Identification
HMDB Protein ID HMDBP07560
Secondary Accession Numbers
  • 13268
Name Signal transduction protein CBL-C
Synonyms
  1. RING finger protein 57
  2. SH3-binding protein CBL-3
  3. SH3-binding protein CBL-C
Gene Name CBLC
Protein Type Unknown
Biological Properties
General Function Involved in signal transducer activity
Specific Function Regulator of EGFR mediated signal transduction
Pathways Not Available
Reactions Not Available
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
protein binding
molecular transducer activity
signal transducer activity
calcium ion binding
Process
signaling
signaling pathway
cell surface receptor linked signaling pathway
Cellular Location
  1. Nucleus (Potential)
Gene Properties
Chromosome Location Chromosome:1
Locus 19q13.2
SNPs CBLC
Gene Sequence 
>1425 bp
ATGGCTCTGGCGGTGGCCCCGTGGGGGCGACAGTGGGAAGAGGCCCGCGCCCTGGGCCGG
GCAGTCAGGATGCTGCAGCGCCTAGAAGAGCAATGCGTCGACCCCCGGCTGTCCGTGAGT
CCCCCTTCGCTGCGGGACCTGCTGCCCCGCACAGCGCAGCTGCTTCGAGAGGTGGCCCAT
TCTCGGCGGGCGGCCGGCGGAGGCGGCCCCGGGGGTCCCGGCGGCTCTGGGGACTTTCTA
CTCATCTACCTGGCCAATCTGGAGGCCAAGAGCAGGCAGGTGGCCGCGCTGCTGCCTCCC
CGGGGCCGAAGGAGTGCCAACGACGAGCTCTTCCGGGCGGGCTCCAGACTCAGGCGACAG
CTGGCCAAGCTGGCCATCATCTTCAGCCACATGCACGCAGAGCTGCACGCACTCTTCCCC
GGGGGAAAGTACTGTGGACACATGTACCAGCTCACCAAGGCCCCCGCCCACACCTTCTGG
AGGGAAAGTTGCGGAGCCCGGTGTGTGCTGCCCTGGGCTGAGTTTGAGTCCCTCCTGGGC
ACCTGCCACCCTGTGGAACCAGGCTGCACAGCCCTGGCCTTGCGCACCACCATTGACCTC
ACCTGCAGCGGGCACGTGTCCATCTTCGAGTTCGACGTCTTCACCAGGCTCTTTCAGCCA
TGGCCAACACTCCTCAAGAACTGGCAGCTCCTGGCAGTCACCCACCCAGGCTACATGGCC
TTCCTCACCTATGATGAGGTCCAAGAGCGTCTGCAGGCCTGCAGAGACAAGCCAGGCAGT
TACATCTTCCGGCCCAGCTGTACTCGCCTGGGGCAGTGGGCCATCGGCTATGTGAGCTCA
GATGGCAGCATCCTGCAGACCATCCCTGCCAACAAACCCCTGTCCCAGGTGCTCCTGGAG
GGACAGAAGGACGGCTTCTACCTCTACCCAGATGGAAAGACCCACAACCCAGACCTGACT
GAGCTCGGCCAGGCAGAACCCCAGCAGCGCATCCACGTGTCAGAGGAGCAGCTGCAGCTC
TACTGGGCCATGGACTCCACATTTGAGCTCTGCAAGATCTGTGCTGAGAGCAACAAGGAT
GTGAAGATTGAGCCGTGCGGGCACCTGCTCTGCAGCTGCTGCCTGGCTGCCTGGCAGCAC
TCGGACAGCCAGACCTGCCCCTTCTGCCGCTGCGAGATCAAGGGCTGGGAGGCCGTGAGT
ATCTACCAGTTCTACGGTCAGGCTACTGCTGAGGACTCAGGGAACAGCAGTGACCAGGAA
GGCAGGGAGTTGGAGCTGGGGCAGGTGCCCCTTTCGGCTCCTCCATTGCCCCCACGGCCA
GATCTGCCCCCCAGGAAGCCCAGAAATGCCCAGCCGAAAGTGAGACTCCTAAAGGGGAAC
TCCCCTCCAGCTGCGCTGGGACCCCAGGACCCTGCCCCGGCCTGA
Protein Properties
Number of Residues 474
Molecular Weight 52455.5
Theoretical pI 7.73
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Signal transduction protein CBL-C
MALAVAPWGRQWEEARALGRAVRMLQRLEEQCVDPRLSVSPPSLRDLLPRTAQLLREVAH
SRRAAGGGGPGGPGGSGDFLLIYLANLEAKSRQVAALLPPRGRRSANDELFRAGSRLRRQ
LAKLAIIFSHMHAELHALFPGGKYCGHMYQLTKAPAHTFWRESCGARCVLPWAEFESLLG
TCHPVEPGCTALALRTTIDLTCSGHVSIFEFDVFTRLFQPWPTLLKNWQLLAVNHPGYMA
FLTYDEVQERLQACRDKPGSYIFRPSCTRLGQWAIGYVSSDGSILQTIPANKPLSQVLLE
GQKDGFYLYPDGKTHNPDLTELGQAEPQQRIHVSEEQLQLYWAMDSTFELCKICAESNKD
VKIEPCGHLLCSCCLAAWQHSDSQTCPFCRCEIKGWEAVSIYQFHGQATAEDSGNSSDQE
GRELELGQVPLSAPPLPPRPDLPPRKPRNAQPKVRLLKGNSPPAALGPQDPAPA
GenBank ID Protein 6291532
UniProtKB/Swiss-Prot ID Q9ULV8
UniProtKB/Swiss-Prot Entry Name CBLC_HUMAN
PDB IDs Not Available
GenBank Gene ID AB028645
GeneCard ID CBLC
GenAtlas ID CBLC
HGNC ID HGNC:15961
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP: Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9. [PubMed:15302935 ]
  3. Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T: Molecular cloning and characterization of a novel cbl-family gene, cbl-c. Gene. 1999 Oct 18;239(1):145-54. [PubMed:10571044 ]
  4. Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S: cbl-3: a new mammalian cbl family protein. Oncogene. 1999 Jun 3;18(22):3365-75. [PubMed:10362357 ]