Hmdb loader
Identification
HMDB Protein ID HMDBP07552
Secondary Accession Numbers
  • 13260
Name Macrophage-capping protein
Synonyms
  1. Actin regulatory protein CAP-G
Gene Name CAPG
Protein Type Unknown
Biological Properties
General Function Involved in actin binding
Specific Function Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
protein binding
cytoskeletal protein binding
actin binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Melanosome
Gene Properties
Chromosome Location Chromosome:2
Locus 2p11.2
SNPs CAPG
Gene Sequence
>1047 bp
ATGTACACAGCCATTCCCCAGAGTGGCTCTCCATTCCCAGGCTCAGTGCAGGATCCAGGC
CTGCATGTGTGGCGGGTGGAGAAGCTGAAGCCGGTGCCTGTGGCGCAAGAGAACCAGGGC
GTCTTCTTCTCGGGGGACTCCTACCTAGTGCTGCACAATGGCCCAGAAGAGGTTTCCCAT
CTGCACCTGTGGATAGGCCAGCAGTCATCCCGGGATGAGCAGGGGGCCTGTGCCGTGCTG
GCTGTGCACCTCAACACGCTGCTGGGAGAGCGGCCTGTGCAGCACCGCGAGGTGCAGGGC
AATGAGTCTGACCTCTTCATGAGCTACTTCCCACGGGGCCTCAAGTACCAGGAAGGTGGT
GTGGAGTCAGCATTTCACAAGACCTCCACAGGAGCCCCAGCTGCCATCAAGAAACTCTAC
CAGGTGAAGGGGAAGAAGAACATCCGTGCCACCGAGCGGGCACTGAACTGGGACAGCTTC
AACACTGGGGACTGCTTCATCCTGGACCTGGGCCAGAACATCTTCGCCTGGTGTGGTGGA
AAGTCCAACATCCTGGAACGCAACAAGGCGAGGGACCTGGCCCTGGCCATCCGGGACAGT
GAGCGACAGGGCAAGGCCCAGGTGGAGATTGTCACTGATGGGGAGGAGCCTGCTGAGATG
ATCCAGGTCCTGGGCCCCAAGCCTGCTCTGAAGGAGGGCAACCCTGAGGAAGACCTCACA
GCTGACAAGGCAAATGCCCAGGCCGCAGCTCTGTATAAGGTCTCTGATGCCACTGGACAG
ATGAACCTGACCAAGGTGGCTGACTCCAGCCCATTTGCCCTTGAACTGCTGATATCTGAT
GACTGCTTTGTGCTGGACAACGGGCTCTGTGGCAAGATCTATATCTGGAAGGGGCGAAAA
GCGAATGAGAAGGAGCGGCAGGCAGCCCTGCAGGTGGCCGAGGGCTTCATCTCGCGCATG
CAGTACGCCCCGAACACTCAGGTGGAGATTCTGCCTCAGGGCCATGAGAGTCCCATCTTC
AAGCAATTTTTCAAGGACTGGAAATGA
Protein Properties
Number of Residues 348
Molecular Weight 38517.3
Theoretical pI 6.18
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Macrophage-capping protein
MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSH
LHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGG
VESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGG
KSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLT
ADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRK
ANEKERQAALQVAEGFISRMQYAPNTQVEILPQGRESPIFKQFFKDWK
GenBank ID Protein 62988741
UniProtKB/Swiss-Prot ID P40121
UniProtKB/Swiss-Prot Entry Name CAPG_HUMAN
PDB IDs
GenBank Gene ID AC062037
GeneCard ID CAPG
GenAtlas ID CAPG
HGNC ID HGNC:1474
References
General References
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  7. Southwick FS: Gain-of-function mutations conferring actin-severing activity to human macrophage cap G. J Biol Chem. 1995 Jan 6;270(1):45-8. [PubMed:7814409 ]