Hmdb loader
Identification
HMDB Protein ID HMDBP07543
Secondary Accession Numbers
  • 13251
Name Calpain-14
Synonyms
  1. CANP 14
  2. Calcium-activated neutral proteinase 14
Gene Name CAPN14
Protein Type Unknown
Biological Properties
General Function Involved in calcium-dependent cysteine-type endopeptidase activity
Specific Function Calcium-regulated non-lysosomal thiol-protease
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
endopeptidase activity
cysteine-type endopeptidase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
calcium-dependent cysteine-type endopeptidase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
calcium ion binding
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:2
Locus 2p23.1-p21
SNPs CAPN14
Gene Sequence
>2055 bp
ATGTCTCTGTGGCCACCTTTCCGATGCAGATGGAAGCTGGCGCCAAGGTACTCTAGGAGG
GCGTCTCCACAGCAACCCCAACAGGACTTTGAGGCCCTGCTGGCAGAGTGCCTGAGGAAT
GGCTGCCTCTTTGAAGACACCAGCTTCCCGGCCACCCTGAGCTCCATCGGCAGTGGCTCC
CTGCTGCAGAAGCTGCCACCCCGCCTGCAGTGGAAGAGGCCCCCGGAGCTGCACAGCAAT
CCCCAGTTTTATTTTGCCAAGGCCAAAAGGCTGGATCTGTGCCAGGGGATAGTAGGAGAC
TGCTGGTTCTTGGCTGCTTTGCAAGCTCTGGCCTTGCACCAGGACATCCTGAGCCGGGTT
GTTCCCCTGAATCAGAGTTTCACTGAGAAGTATGCTGGCATCTTCCGGTTCTGGTTCTGG
CACTATGGGAACTGGGTTCCTGTGGTGATCGATGACCGTCTGCCTGTGAATGAGGCTGGC
CAGCTGGTCTTTGTCTCCTCCACCTATAAGAACTTGTTCTGGGGAGCACTTCTGGAAAAG
GCCTATGCCAAGCTCTCTGGTTCCTATGAAGACTTGCAGTCAGGACAGGTGTCTGAAGCC
CTTGTAGACTTCACTGGAGGGGTGACAATGACCATCAACCTGGCAGAAGCCCATGGCAAC
CTCTGGGACATCCTCATCGAAGCCACCTACAACAGAACCCTCATTGGCTGCCAGACCCAC
TCAGGGGAGAAGATTCTGGAGAATGGGCTGGTGGAAGGCCATGCCTATACTCTCACAGGA
ATCAGGAAGGTGACCTGCAAACATAGACCTGAATATCTCGTCAAGCTACGGAACCCCTGG
GGAAAGGTGGAATGGAAAGGAGACTGGAGTGACAGTTCAAGTAAATGGGAGCTGCTGAGC
CCCAAGGAGAAGATTCTGCTTCTGAGGAAAGACAATGACGGAGAATTCTGGATGACGCTG
CAGGACTTTAAAACACATTTCGTGCTCCTGGTTATCTGTAAACTGACCCCAGGCCTGTTG
AGCCAGGAGGCGGCCCAGAAGTGGACGTACACCATGCGGGAGGGGAGATGGGAGAAGCGG
AGCACAGCTGGTGGCCAGAGGCAGTTGCTGCAGGACACATTTTGGAAGAACCCGCAGTTC
CTGCTGTCTGTCTGGAGGCCCGAGGAGGGCAGGAGATCCCTGAGGCCCTGCAGCGTGCTG
GTGTCCCTGCTCCAGAAGCCCAGGCACAGGTGCCGCAAGCGGAAGCCTCTCCTCGCCATT
GGCTTCTACCTGTATAGGATGAACAAGTACCATGATGACCAGAGGAGACTGCCCCCTGAG
TTCTTCCAGAGAAACACTCCTCTGAGCCAGCCTGATAGGTTTCTCAAGGAGAAAGAAGTG
AGTCAGGAGCTGTGTCTGGAACCAGGGACGTACCTCATCGTGCCCTGCATATTGGAGGCC
CACCAGAAGTCAGAGTTCGTCCTCAGGGTCTTCTCCAGGAAGCACATCTTTTATGAAATT
GGCAGCAATTCTGGTGTCGTCTTCTCAAAGGAGATAGAAGACCAAAATGAAAGGCAGGAT
GAATTCTTCACCAAATTCTTTGAAAAGCATCCAGAGATTAATGCAGTTCAACTTCAGAAC
CTCCTGAACCAGATGACCTGGTCAAGTCTGGGGAGCAGACAGCCCTTCTTTAGCCTGGAA
GCCTGCCAGGGGATCCTGGCCTTACTGGACCTTAATGCATCAGGTACTATGAGCATCCAG
GAATTCAGGGACCTGTGGAAGCAGCTGAAGCTCTCTCAGAAGGTTTTCCACAAGCAAGAC
CGTGGGTCAGGATACCTGAACTGGGAGCAGCTGCACGCTGCCATGAGGGAGGCAGGAATC
ATGCTCAGTGATGACGTCTGTCAGCTGATGCTCATCCGCTACGGCGGCCCCCGCCTCCAG
ATGGACTTTGTCAGTTTCATCCACTTGATGCTGCGTGTAGAGAACATGGAGGATGTCTTC
CAAAACTTAACCCAAGATGGCAAAGGGATATACCTCCAGAAGCCAGAGTGGATGATGATG
GCACTGTACTCCTGA
Protein Properties
Number of Residues 684
Molecular Weight 79567.1
Theoretical pI 8.78
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Calpain-14
MSLWPPFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIGSGS
LLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRV
VPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEK
AYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH
SGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLS
PKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKR
STAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAI
GFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEA
HQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQN
LLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD
RGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVF
QNLTQDGKGIYLQKPEWMMMALYS
GenBank ID Protein 223468608
UniProtKB/Swiss-Prot ID A8MX76
UniProtKB/Swiss-Prot Entry Name CAN14_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001145122.1
GeneCard ID CAPN14
GenAtlas ID CAPN14
HGNC ID HGNC:16664
References
General References
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  3. Dear TN, Boehm T: Identification and characterization of two novel calpain large subunit genes. Gene. 2001 Aug 22;274(1-2):245-52. [PubMed:11675017 ]