Hmdb loader
Identification
HMDB Protein ID HMDBP07526
Secondary Accession Numbers
  • 13234
Name Cadherin-related family member 4
Synonyms
  1. Cadherin-like protein 29
Gene Name CDHR4
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Membrane
  2. Single-pass type I membrane protein (Potential)
Gene Properties
Chromosome Location Chromosome:3
Locus 3p21.31
SNPs CDHR4
Gene Sequence
>2367 bp
ATGGTGCTGCTCAGGCTCCTCGTGTTCCTCTTTGCTCCGGTGGTCTCTGACCTCTGCAGC
CTGCCCTGCTTTATAAATGTCTCTGAGAGCCAGGGCCCTGGCACAGTCCTTCAGTTTTTA
TCCTTCAACTGCTCCTCCTACACGCCCACACCCACCCTGGAGTTGCTCAATGTCCAGCCA
CCCACCACCTTCTTCAACCCACCCAGCTTGGCCAGGTGGCAAGGGACCTATGTGGGCAAG
TTGACCTTGAGCAGCTCTGCTCAGTTGGATGCCCTGATGGTGAACCACTACAAGGTGCAG
CTGAAGTTCACATGTGGCAACCATGTGATGGAGGGCTCACTCTCTGTGGATGTGCAGCGG
GACCTTAGCCATATCCAGTGTGCTGGTCAATTTGCCAGCCCAGCTGGGGAAATGATTCAG
GTGCCAGAGACAGTCACACCTGGGGCTCGGCTGTACACTCTGCTCCTCCCAGGCCTAGAA
CTCCACGGAGCGCAGATGAGCATTATCAGTGCCCAGGACCTGCCACACTTCCCTGGACCT
TTCTCCATCAATGAGCAAGGTTGGCTGCAGGCACCATCCCAGGGCCTCCTAGGCCAGGCT
CAAAAGGTCTTCCAGCTGCAAATCTCAGTGTCCTTTGGACAAAGGCAAAGCTGCCAAGGG
ATGGTGATAGTGAAGGTTTTGCCTGTTCCCTCCAGCCAGGTCTCCTTCCTCGAGCAGGCT
CAGAATATCACCATCCCTGAGAATCTGGCCCCCGGTAGTGAGGTGGTTCAGGTCCAGGCC
CGGGGTGTCGACCTGCGCTATGAAATCCTGTCTCCGGTGCCCAGCCCACTCTTCTCCATT
GGTCGTGCAGACGGTGTGGTCCGGACCACCACGCCCCTAGAGTTAGCTCGCACCTCAGGC
ACCGCGGTCTCCAGGCTGCAGGTGAAGGCCTTTGAGCAGGGCCAGCTGTGGGCCAGTGCC
AAGCTCAATCTCACCATGAATGTGCAGCTGGTCAACCTCTGGCCTCCACGCTGCCTCCCA
GCGCTTCTGGTGTCCCAAATCCCGGAGACTGCACCCGTGGGCACCGTGCTGAATACTCTC
ACTTGCGAAGATCCGGACTCTGTTGGTGCCACCCTGGACTACAAGCTGTGGTTCCGCAGC
TCTTCCAACCCTGCCAGCCTCTGCCTTTATGACAGAGTCCTTGAGGTGAATGCCACACTG
GACTGTGACACTCCTGGAGCCTGCTTCCAGCATGCAGCCTCCATCCTGGTGCTCGATGGT
GGCCAGCCCCAGATGACCACTGAGGTGCCGGTACTGGTGATGGTGACACCCATCAACGAG
TTCTCCCCAGCCTGTGCCCCTCGCACGTTCCGGGTTCAGGAGGATGCGGCGCCCCACACT
CTACTGGGCTCCGTGGTGGGCACGGATATGGATTACCCTCACGACAACATTGAGTACTAC
ACCTCTGGTGGTCCTACCACCTTTGCTGTGGACCGTCTCAGCGGGGAAGTTCACCTCCTG
GGACCTTTGGACTATGAGCAGCAGAGGCTGTACAGGCTCACTGTCCTTGTGATTGACCAT
GGCCAAGACCAGAACCCCAACCATCACCTCTCAGGCTCCTGTACCATTACCATCGAGGTT
GAGGATGTGAATGACCATGCCCCCGAGTGTGAGCCCCCATTTCAGGAACTCACCATCTAT
GCTCCTCTGGGCCGTAGCGTGGAGGTGACCAAGATGTCATGCCAGATCCCTCAGGAGCCA
CAGCGCCTGATCTACTCCTATAGCATCGTGGGAGGGAATAGCCAGAACCGATTCATCCTG
CAAGGGGCCATCCTGGTGCACAGTGACCTTGTGTTGGGGCCGTTCTGGCCAGAGCAGCCC
CGTACCTATGAGCTACTGATCTGTGTGGCCGATGCAGGCCCCTCCACCCCCCACCTCAGC
ACCACAGCCACCATTATTGTGCATCTAGTTCCCCGGAGGGCCAGCACAGTGGCCACCAGC
ACCCACAGAACCACAGTGCCCTCAACGATGACACCCATGCTCGTGACAGACACAGAGGCT
TTCTGGCAGCCACAGCCCTGGTTTGTGGTGGTGTTGACAGCAACTGGTGCTCTTCTCCTC
TTGGCCCTAGGCTGGCTTCTTGGCAGGCTCCTCCAGGGGTTGGCCCAGCTGCTGCAAGCA
CCCAGCAAACCAGCCCAGGCTTTGCTGCTAAACAGCATCCAGGGAACTGAGGGATCCATC
GAGGGTTTCCTGGAGGCACCGAAGATGGAGATGTCCCAGGCACCCAGCAGTGTCATGAGT
CTGCATTTTGATGGCAGAGCACAGGACTCCCGTACCGGAAGAGACTACCTGTTTAACACA
CACACAGGAGCCCGGCGCTGGCTCTGA
Protein Properties
Number of Residues 788
Molecular Weight 85826.6
Theoretical pI 5.13
Pfam Domain Function
Signals
  • 1-16
Transmembrane Regions
  • 687-707
Protein Sequence
>Cadherin-related family member 4
MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTLELLNVQP
PTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQR
DLSHIQCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGP
FSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQA
QNITIPENLAPGSEVVQVQARGVDLRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSG
TAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTL
TCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDG
GQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYY
TSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEV
EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFIL
QGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATS
THRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQLLQA
PSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRDYLFNT
HTGARRWL
GenBank ID Protein 203097724
UniProtKB/Swiss-Prot ID A6H8M9
UniProtKB/Swiss-Prot Entry Name CDHR4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001007540.2
GeneCard ID CDHR4
GenAtlas ID CDHR4
HGNC ID HGNC:34527
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]