Hmdb loader
Identification
HMDB Protein ID HMDBP07482
Secondary Accession Numbers
  • 13190
Name Coiled-coil and C2 domain-containing protein 1A
Synonyms
  1. FRE under dual repression-binding protein 1
  2. Five repressor element under dual repression-binding protein 1
  3. Freud-1
  4. Putative NF-kappa-B-activating protein 023N
Gene Name CC2D1A
Protein Type Unknown
Biological Properties
General Function Lipid transport and metabolism
Specific Function Transcription factor that binds specifically to the FRE (five repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.12
SNPs CC2D1A
Gene Sequence
>2856 bp
ATGCACAAGAGGAAAGGACCCCCGGGACCCCCGGGCAGAGGCGCCGCGGCCGCCCGCCAG
CTGGGCCTGCTGGTTGACCTCTCCCCAGATGGCCTGATGATCCCTGAGGACGGGGCTAAC
GATGAAGAACTGGAGGCTGAGTTCTTGGCTTTGGTCGGGGGCCAGCCCCCAGCCCTGGAG
AAGCTCAAAGGCAAAGGTCCCTTGCCGATGGAGGCCATTGAGAAGATGGCCAGCCTGTGC
ATGAGAGACCCGGATGAGGATGAGGAGGAGGGGACGGATGAGGACGACTTGGAGGCTGAT
GATGACCTGCTGGCGGAGCTAAATGAGGTCCTTGGAGAGGAGCAGAAGGCTTCAGAGACC
CCACCTCCTGTGGCCCAGCCGAAGCCTGAGGCCCCTCATCCGGGGCTGGAGACCACCTTG
CAGGAGAGGCTGGCGCTCTATCAGACAGCAATTGAAAGCGCCAGACAAGCTGGAGACAGC
GCCAAGATGCGGCGCTACGATCGGGGGCTTAAAACACTGGAAAACCTGCTCGCCTCCATC
CGTAAGGGCAATGCCATTGACGAAGCGGACATCCCGCCGCCAGTGGCCATAGGAAAAGGC
CCGGCGTCCACGCCTACCTACAGCCCTGCACCCACCCAGCCGGCCCCTAGAATCGCGTCA
GCCCCAGAGCCCAGGGTCACCCTGGAGGGACCTTCTGCCACCGCCCCAGCCTCATCTCCA
GGCTTGGCTAAGCCCCAGATGCCCCCAGGTCCCTGCAGCCCTGGCCCTCTGGCCCAGTTG
CAGAGCCGCCAGCGCGACTACAAGCTGGCTGCCCTCCACGCCAAGCAGCAGGGAGATACC
ACTGCTGCCGCTAGACACTTCCGCGTGGCTAAGAGCTTTGATGCTGTCTTGGAGGCCCTG
AGCCGGGGTGAGCCCGTGGACCTCTCCTGCCTGCCCCCTCCACCCGACCAGCTGCCCCCA
GACCCACCGTCACCACCGTCGCAGCCTCCGACCCCCGCTACGGCGCCCTCCACAACAGAG
GTGCCCCCACCCCCGAGGACCCTGCTGGAGGCGCTGGAGCAGCGGATGGAGCGGTACCAG
GTGGCCGCAGCCCAGGCCAAGAGCAAGGGGGACCAGCGGAAAGCTCGAATGCACGAGCGC
ATCGTCAAGCAATACCAAGATGCCATCCGAGCCCACAAGGCTGGCCGAGCCGTGGATGTC
GCTGAATTGCCCGTGCCCCCAGGCTTCCCCCCAATCCAGGGCCTGGAGGCCACCAAGCCC
ACCCAGCAGAGTCTGGTGGGTGTCCTGGAGACTGCCATGAAGCTGGCCAACCAGGATGAA
GGCCCAGAGGATGAAGAGGATGAGGTGCCTAAGAAGCAGAACAGCCCTGTGGCCCCCACA
GCCCAGCCCAAAGCCCCACCCTCAAGAACTCCCCAGTCGGGATCAGCCCCAACAGCCAAA
GCGCCCCCCAAAGCCACATCCACCAGAGCCCAGCAGCAGCTGGCCTTCCTAGAGGGCCGC
AAGAAGCAGCTCCTGCAGGCCGCACTGCGAGCCAAGCAGAAAAACGACGTGGAGGGTGCC
AAGATGCACCTGCGCCAAGCCAAGGGACTGGAGCCTATGCTGGAGGCCTCGCGCAATGGG
CTGCCTGTGGACATCACCAAGGTGCCGCCTGCCCCTGTCAACAAGGACGACTTTGCCCTG
GTCCAGCGGCCTGGCCCGGGTCTGTCTCAGGAGGCCGCCCGGCGCTATGGTGAACTCACC
AAGCTCATACGGCAGCAGCACGAGATGTGCCTGAACCACTCAAACCAATTCACCCAGCTG
GGCAACATCACTGAAACCACCAAGTTTGAAAAGTTGGCGGAGGACTGTAAGCGGAGCATG
GACATTCTGAAGCAAGCCTTCGTCCGGGGTCTCCCCACGCCCACCGCCCGCTTTGAGCAA
AGGACCTTCAGCGTCATCAAGATCTTCCCTGACCTCAGCAGCAACGACATGCTCCTCTTC
ATCGTGAAGGGCATCAACTTGCCCACACCCCCAGGACTGTCCCCTGGCGATCTGGATGTC
TTTGTTCGGTTTGACTTCCCCTATCCCAACGTGGAAGAAGCTCAGAAAGACAAGACCAGT
GTGATCAAGAACACAGACTCCCCTGAGTTCAAGGAGCAGTTCAAACTCTGCATCAACCGC
AGCCACCGTGGCTTCCGAAGGGCCATCCAGACCAAGGGCATCAAGTTCGAAGTGGTTCAC
AAGGGGGGGCTGTTCAAGACTGACCGGGTGCTGGGGACAGCCCAGCTGAAGCTGGATGCA
CTGGAGATAGCATGTGAGGTCCGGGAGATCCTTGAGGTCCTGGATGGTCGCCGGCCCACA
GGGGGGCGACTGGAGGTAATGGTCCGGATTCGGGAGCCACTGACAGCCCAGCAGTTGGAG
ACGACGACAGAGAGGTGGCTAGTCATTGACCCTGTGCCGGCAGCTGTGCCCACACAGGTT
GCTGGGCCCGAAGGGAAGGCCCCTCCTGTGCCTGCCCCTGCAAGGGAGCCAGGGAACAGA
TCAGCCCGGCCCCTGCATAGCCTCAGTGTGCTGGCGTTTGACCAAGAGCGTCTGGAGCGG
AAGATCCTGGCCCTCAGGCAGGCGCGGCGGCCGGTGCCCCCAGAAGTGGCCCAGCAGTAC
CAGGACATCATGCAACGCAGCCAGTGGCAGAGGGCACAGCTGGAGCAGGGGGGTGTGGGC
ATCCGACGGGAATACACAGCCCAGCTGGAGCGGCAGCTGCAGTTCTACACGGAGGCTGCC
CGGCGCCTGGGCAACGATGGCAGCAGGGATGCTGCAAAGGAGGCGCTCTATAGGCGGAAT
CTGGTAGGGAGTGAGCTGCAGCGGCTCCGCAGGTGA
Protein Properties
Number of Residues 951
Molecular Weight 104061.5
Theoretical pI 8.26
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Coiled-coil and C2 domain-containing protein 1A
MHKRKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPALE
KLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASET
PPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASI
RKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSP
GLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEAL
SRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQ
VAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKP
TQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK
APPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNG
LPVDITKVPPAPVNKDDFALVQRPGPGLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQL
GNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRTFSVIKIFPDLSSNDMLLF
IVKGINLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINR
SHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALEIACEVREILEVLDGRRPT
GGRLEVMVRIREPLTAQQLETTTERWLVIDPVPAAVPTQVAGPKGKAPPVPAPARESGNR
SARPLHSLSVLAFDQERLERKILALRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGVG
IRREYAAQLERQLQFYTEAARRLGNDGSRDAAKEALYRRNLVESELQRLRR
GenBank ID Protein 31455459
UniProtKB/Swiss-Prot ID Q6P1N0
UniProtKB/Swiss-Prot Entry Name C2D1A_HUMAN
PDB IDs Not Available
GenBank Gene ID AB097002
GeneCard ID CC2D1A
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol. 2005 Jan;23(1):94-101. Epub 2004 Dec 12. [PubMed:15592455 ]
  4. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  5. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  6. Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP: A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10. [PubMed:16964243 ]
  7. Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51. doi: 10.1021/pr0705441. Epub 2008 Jan 26. [PubMed:18220336 ]
  8. Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene. 2003 May 22;22(21):3307-18. [PubMed:12761501 ]
  9. Basel-Vanagaite L, Attia R, Yahav M, Ferland RJ, Anteki L, Walsh CA, Olender T, Straussberg R, Magal N, Taub E, Drasinover V, Alkelai A, Bercovich D, Rechavi G, Simon AJ, Shohat M: The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation. J Med Genet. 2006 Mar;43(3):203-10. Epub 2005 Jul 20. [PubMed:16033914 ]