Hmdb loader
Identification
HMDB Protein ID HMDBP07472
Secondary Accession Numbers
  • 13180
Name Bone morphogenetic protein 8A
Synonyms
  1. BMP-8A
Gene Name BMP8A
Protein Type Unknown
Biological Properties
General Function Involved in growth factor activity
Specific Function Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis
Pathways Not Available
Reactions Not Available
GO Classification
Component
extracellular region
Function
binding
protein binding
receptor binding
growth factor activity
Process
growth
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:1
Locus 1p34.3
SNPs BMP8A
Gene Sequence
>1209 bp
ATGGCCGCGCGCCCCGGACCGCTCTGGCTTCTGGGCCTGACGTTGTGCGCGCTGGGCGGG
GGCGGCCCCGGCCTGCGACCCCCGCCCGGCTGTCCCCAGCGACGTCTGGGCGCGCGCGAG
CGCCGGGACGTGCAGCGCGAGATCCTGGCGGTGCTCGGGCTACCCGGGCGGCCCCGGCCC
CGCGCGCCACCCGCCGCCTCCCGGCTGCCCGCGTCCGCGCCGCTCTTCATGCTGGACCTG
TACCACGCCATGGCTGGCGACGACGACGAGGACGGCGCGCCCGCGGAGCAGCGCCTGGGC
CGCGCCGACCTGGTCATGAGCTTCGTCAACATGGTGGAGCGAGACCGTGCCCTGGGCCAC
CAGGAGCCCCATTGGAAGGAGTTCCGCTTTGACCTGACCCAGATCCCGGCTGGGGAGGCG
GTCACAGCTGCGGAGTTCCGGATTTACAAGGTGCCCAGCATCCACCTGCTCAACAGGACC
CTCCACGTCAGCATGTTCCAGGTGGTCCAGGAGCAGTCCAACAGGGAGTCTGACTTGTTC
TTTTTGGATCTTCAGACGCTCCGAGCTGGAGACGAGGGCTGGCTGGTGCTGGATGTCACA
GCAGCCAGTGACTGCTGGTTGCTGAAGCGTCACAAGGACCTGGGACTCCGCCTCTATGTG
GAGACTGAGGACGGGCACAGCGTGGATCCTGGCCTGGCCGGCCTGCTGGGTCAACGGGCC
CCACGCTCCCAACAGCCTTTCGTGGTCACTTTCTTCAGGGCCAGTCCGAGTCCCATCCGC
ACCCCTCGGGCAGTGAGGCCACTGAGGAGGAGGCAACCGAAGAAAAGCAACGAGCTGCCG
CAGGCCAACCGACTCCCAGGGATCTTTGATGACGTCCGCGGCTCCCACGGCCGGCAGGTC
TGCCGTCGGCACGAGCTCTACGTCAGCTTCCAGGACCTTGGCTGGCTGGACTGGGTCATC
GCCCCCCAAGGCTACTCAGCCTATTACTGTGAGGGGGAGTGCTCCTTCCCGCTGGACTCC
TGCATGAACGCCACCAACCACGCCATCCTGCAGTCCCTGGTGCACCTGATGAAGCCAAAC
GCAGTCCCCAAGGCGTGCTGTGCACCCACCAAGCTGAGCGCCACCTCTGTGCTCTACTAT
GACAGCAGCAACAACGTCATCCTGCGCAAGCACCGCAACATGGTGGTCAAGGCCTGCGGC
TGCCACTGA
Protein Properties
Number of Residues 402
Molecular Weight 44798.0
Theoretical pI 8.88
Pfam Domain Function
Signals
  • 1-19
Transmembrane Regions
  • None
Protein Sequence
>Bone morphogenetic protein 8A
MAARPGPLWLLGLTLCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRP
RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAEQRLGRADLVMSFVNMVERDRALGH
QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLF
FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA
PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQV
CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPN
AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
GenBank ID Protein 55959645
UniProtKB/Swiss-Prot ID Q7Z5Y6
UniProtKB/Swiss-Prot Entry Name BMP8A_HUMAN
PDB IDs Not Available
GenBank Gene ID AL365277
GeneCard ID BMP8A
GenAtlas ID BMP8A
HGNC ID HGNC:21650
References
General References
  1. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [PubMed:16710414 ]