Human Metabolome Database: Showing Protein Glycine N-acyltransferase (HMDBP07349)

Identification Biological properties Gene properties Protein properties External links References XML Show 101 metabolites

Identification

HMDB Protein ID

HMDBP07349

Secondary Accession Numbers

12971

Name

Glycine N-acyltransferase

Synonyms

AAc
Acyl-CoA:glycine N-acyltransferase
Aralkyl acyl-CoA N-acyltransferase
Aralkyl acyl-CoA:amino acid N-acyltransferase
HRP-1(CLP)
Benzoyl-coenzyme A:glycine N-acyltransferase
Glycine N-benzoyltransferase

Gene Name

GLYAT

Protein Type

Enzyme

Biological Properties

General Function

Involved in glycine N-acyltransferase activity

Specific Function

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Pathways

Phenylalanine metabolism
Phenylalanine metabolism

Reactions

Acyl-CoA + Glycine → Coenzyme A + N-acylglycine	details
Benzoyl-CoA + Glycine → Coenzyme A + Hippuric acid	details
Phenylacetyl-CoA + Glycine → Phenylacetylglycine + Coenzyme A	details
4-Hydroxybenzoic acid → 4-Hydroxyhippuric acid	details
Benzoic acid → Hippuric acid	details
Protocatechuic acid → 2-{[(3,4-dihydroxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
3-Hydroxybenzoic acid → 3-Hydroxyhippuric acid	details
m-Trigallic acid → 2-[({3-[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]-4,5-dihydroxyphenyl}(hydroxy)methylidene)amino]acetic acid	details
3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoic acid → 2-({[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)phenyl](hydroxy)methylidene}amino)acetic acid	details
Gallic acid → 2-{[hydroxy(3,4,5-trihydroxyphenyl)methylidene]amino}acetic acid	details
3-[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]-2,4,5-trihydroxybenzoic acid → 2-[({3-[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]-2,4,5-trihydroxyphenyl}(hydroxy)methylidene)amino]acetic acid	details
3,4-dihydroxy-5-[2,4,5-trihydroxy-3-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]benzoic acid → 2-[({3,4-dihydroxy-5-[2,4,5-trihydroxy-3-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]phenyl}(hydroxy)methylidene)amino]acetic acid	details
3-[3,4-dihydroxy-5-(2,3,4,5-tetrahydroxybenzoyloxy)benzoyloxy]-4,5-dihydroxybenzoic acid → 2-[({3-[3,4-dihydroxy-5-(2,3,4,5-tetrahydroxybenzoyloxy)benzoyloxy]-4,5-dihydroxyphenyl}(hydroxy)methylidene)amino]acetic acid	details
2,4,5-trihydroxy-3-(3,4,5-trihydroxybenzoyloxy)benzoic acid → 2-({hydroxy[2,4,5-trihydroxy-3-(3,4,5-trihydroxybenzoyloxy)phenyl]methylidene}amino)acetic acid	details
3,4-dihydroxy-5-(2,3,4,5-tetrahydroxybenzoyloxy)benzoic acid → 2-({[3,4-dihydroxy-5-(2,3,4,5-tetrahydroxybenzoyloxy)phenyl](hydroxy)methylidene}amino)acetic acid	details
2,3,4-trihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoic acid → 2-({hydroxy[2,3,4-trihydroxy-5-(3,4,5-trihydroxybenzoyloxy)phenyl]methylidene}amino)acetic acid	details
2,3,4,5-tetrahydroxybenzoic acid → 2-{[hydroxy(2,3,4,5-tetrahydroxyphenyl)methylidene]amino}acetic acid	details
3,5-Dihydroxybenzoic acid → 2-{[(3,5-dihydroxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
1-oxo-1H-isochromene-3-carboxylic acid → 2-{[hydroxy(1-oxo-1H-isochromen-3-yl)methylidene]amino}acetic acid	details
7-hydroxy-1-oxo-1H-isochromene-3-carboxylic acid → 2-[(7-hydroxy-1-oxo-1H-isochromen-3-yl)formamido]acetic acid	details
6-hydroxy-1-oxo-1H-isochromene-3-carboxylic acid → 2-{[hydroxy(6-hydroxy-1-oxo-1H-isochromen-3-yl)methylidene]amino}acetic acid	details
5-hydroxy-1-oxo-1H-isochromene-3-carboxylic acid → 2-[(5-hydroxy-1-oxo-1H-isochromen-3-yl)formamido]acetic acid	details
6-hydroxy-7-methoxy-2H-1,3-benzodioxole-5-carboxylic acid → 2-{[hydroxy(6-hydroxy-7-methoxy-2H-1,3-benzodioxol-5-yl)methylidene]amino}acetic acid	details
7-hydroxy-6-methoxy-2H-1,3-benzodioxole-5-carboxylic acid → 2-{[hydroxy(7-hydroxy-6-methoxy-2H-1,3-benzodioxol-5-yl)methylidene]amino}acetic acid	details
4,4',5,5',6,6'-hexahydroxy-[1,1'-biphenyl]-2,2'-dicarboxylic acid → 6'-[(carboxymethyl)-C-hydroxycarbonimidoyl]-2',3',4,4',5,6-hexahydroxy-[1,1'-biphenyl]-2-carboxylic acid	details
3,4,8,9,10-pentahydroxy-6-oxo-6H-benzo[c]chromene-1-carboxylic acid → 2-{[hydroxy({3,4,8,9,10-pentahydroxy-6-oxo-6H-benzo[c]chromen-1-yl})methylidene]amino}acetic acid	details
3,4-Methylenedioxybenzoic acid → 2-{[(2H-1,3-benzodioxol-5-yl)(hydroxy)methylidene]amino}acetic acid	details
6-hydroxy-2H-1,3-benzodioxole-5-carboxylic acid → 2-{[hydroxy(6-hydroxy-2H-1,3-benzodioxol-5-yl)methylidene]amino}acetic acid	details
4-methoxy-1-benzofuran-5-carboxylic acid → 2-{[hydroxy(4-methoxy-1-benzofuran-5-yl)methylidene]amino}acetic acid	details
7-[4-(1,2-dihydroxyethyl)-5,11,12,13-tetrahydroxy-8-oxo-3,7-dioxatricyclo[7.4.0.0²,⁶]trideca-1(13),9,11-trien-10-yl]-3,4,8,9,10-pentahydroxy-6-oxo-6H-benzo[c]chromene-1-carboxylic acid → 2-[({7-[4-(1,2-dihydroxyethyl)-5,11,12,13-tetrahydroxy-8-oxo-3,7-dioxatricyclo[7.4.0.0²,⁶]trideca-1(13),9,11-trien-10-yl]-3,4,8,9,10-pentahydroxy-6-oxo-6H-benzo[c]chromen-1-yl}(hydroxy)methylidene)amino]acetic acid	details
2-[4-(1,2-dihydroxyethyl)-5,11,12,13-tetrahydroxy-8-oxo-3,7-dioxatricyclo[7.4.0.0²,⁶]trideca-1(13),9,11-trien-10-yl]-3,4,8,9,10-pentahydroxy-6-oxo-6H-benzo[c]chromene-1-carboxylic acid → 2-({2-[4-(1,2-dihydroxyethyl)-5,11,12,13-tetrahydroxy-8-oxo-3,7-dioxatricyclo[7.4.0.0²,⁶]trideca-1(13),9,11-trien-10-yl]-3,4,8,9,10-pentahydroxy-6-oxo-6H-benzo[c]chromen-1-yl}formamido)acetic acid	details
3,4,8,9,10-pentahydroxy-6-oxo-7-[5,6,12,13,14-pentahydroxy-4-(hydroxymethyl)-9-oxo-3,8-dioxatricyclo[8.4.0.0²,⁷]tetradeca-1(14),10,12-trien-11-yl]-6H-benzo[c]chromene-1-carboxylic acid → 2-{[hydroxy({3,4,8,9,10-pentahydroxy-6-oxo-7-[5,6,12,13,14-pentahydroxy-4-(hydroxymethyl)-9-oxo-3,8-dioxatricyclo[8.4.0.0²,⁷]tetradeca-1(14),10,12-trien-11-yl]-6H-benzo[c]chromen-1-yl})methylidene]amino}acetic acid	details
3,4,8,9,10-pentahydroxy-6-oxo-2-[5,6,12,13,14-pentahydroxy-4-(hydroxymethyl)-9-oxo-3,8-dioxatricyclo[8.4.0.0²,⁷]tetradeca-1(14),10,12-trien-11-yl]-6H-benzo[c]chromene-1-carboxylic acid → 2-({3,4,8,9,10-pentahydroxy-6-oxo-2-[5,6,12,13,14-pentahydroxy-4-(hydroxymethyl)-9-oxo-3,8-dioxatricyclo[8.4.0.0²,⁷]tetradeca-1(14),10,12-trien-11-yl]-6H-benzo[c]chromen-1-yl}formamido)acetic acid	details
3,4,8,9,10-pentahydroxy-6-oxo-2-[5,6,7-trihydroxy-1-oxo-3-(1,2,3,4-tetrahydroxybutyl)-1H-isochromen-8-yl]-6H-benzo[c]chromene-1-carboxylic acid → 2-{[hydroxy({3,4,8,9,10-pentahydroxy-6-oxo-2-[5,6,7-trihydroxy-1-oxo-3-(1,2,3,4-tetrahydroxybutyl)-1H-isochromen-8-yl]-6H-benzo[c]chromen-1-yl})methylidene]amino}acetic acid	details
2,4,6-Trihydroxybenzoic acid → 2-{[hydroxy(2,4,6-trihydroxyphenyl)methylidene]amino}acetic acid	details
2,3,4,6-tetrahydroxybenzoic acid → 2-{[hydroxy(2,3,4,6-tetrahydroxyphenyl)methylidene]amino}acetic acid	details
2,3,4-Trihydroxybenzoic acid → 2-{[hydroxy(2,3,4-trihydroxyphenyl)methylidene]amino}acetic acid	details
2,4,5-trihydroxybenzoic acid → 2-{[hydroxy(2,4,5-trihydroxyphenyl)methylidene]amino}acetic acid	details
p-Anisic acid → 2-[(4-methoxyphenyl)formamido]acetic acid	details
2-hydroxy-4-methoxybenzoic acid → 2-{[hydroxy(2-hydroxy-4-methoxyphenyl)methylidene]amino}acetic acid	details
Salicylic acid → Salicyluric acid	details
2-(2H-1,3-benzodioxol-5-yl)-6-hydroxy-1-benzofuran-5-carboxylic acid → 2-{[2-(2H-1,3-benzodioxol-5-yl)-6-hydroxy-1-benzofuran-5-yl]formamido}acetic acid	details
2-(6-hydroxy-2H-1,3-benzodioxol-5-yl)-1-benzofuran-5-carboxylic acid → 2-({hydroxy[2-(6-hydroxy-2H-1,3-benzodioxol-5-yl)-1-benzofuran-5-yl]methylidene}amino)acetic acid	details
2-(2H-1,3-benzodioxol-5-yl)-7-hydroxy-1-benzofuran-5-carboxylic acid → 2-({[2-(2H-1,3-benzodioxol-5-yl)-7-hydroxy-1-benzofuran-5-yl](hydroxy)methylidene}amino)acetic acid	details
2-(2H-1,3-benzodioxol-5-yl)-4-hydroxy-1-benzofuran-5-carboxylic acid → 2-({[2-(2H-1,3-benzodioxol-5-yl)-4-hydroxy-1-benzofuran-5-yl](hydroxy)methylidene}amino)acetic acid	details
Syringic acid → 2-{[hydroxy(4-hydroxy-3,5-dimethoxyphenyl)methylidene]amino}acetic acid	details
3-O-Methylgallic acid → 2-{[(3,4-dihydroxy-5-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
3,5-dimethoxybenzoic acid → 2-{[(3,5-dimethoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
3-hydroxy-5-methoxybenzoic acid → 2-{[hydroxy(3-hydroxy-5-methoxyphenyl)methylidene]amino}acetic acid	details
Vanillic acid → Vanilloylglycine	details
3-Methoxybenzoic acid → 2-{[hydroxy(3-methoxyphenyl)methylidene]amino}acetic acid	details
2-Pyrocatechuic acid → 2-{[(2,3-dihydroxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
Gentisic acid → Gentisuric acid	details
2-[7,8,9,12,13,14,17,18,19,25-decahydroxy-24-(hydroxymethyl)-4,22,27-trioxo-3,23,26-trioxahexacyclo[13.10.3.1²,⁶.0⁵,¹⁰.0¹¹,²⁸.0¹⁶,²¹]nonacosa-5(10),6,8,11,13,15(28),16,18,20-nonaen-29-yl]-3,4,5-trihydroxybenzoic acid → 2-[({2-[7,8,9,12,13,14,17,18,19,25-decahydroxy-24-(hydroxymethyl)-4,22,27-trioxo-3,23,26-trioxahexacyclo[13.10.3.1²,⁶.0⁵,¹⁰.0¹¹,²⁸.0¹⁶,²¹]nonacosa-5(10),6,8,11,13,15(28),16,18,20-nonaen-29-yl]-3,4,5-trihydroxyphenyl}(hydroxy)methylidene)amino]acetic acid	details
Indole-3-carboxylic acid → 2-{[hydroxy(1H-indol-3-yl)methylidene]amino}acetic acid	details
5-hydroxy-1H-indole-3-carboxylic acid → 2-{[hydroxy(5-hydroxy-1H-indol-3-yl)methylidene]amino}acetic acid	details
6-hydroxy-1H-indole-3-carboxylic acid → 2-{[hydroxy(6-hydroxy-1H-indol-3-yl)methylidene]amino}acetic acid	details
7-hydroxy-1H-indole-3-carboxylic acid → 2-{[hydroxy(7-hydroxy-1H-indol-3-yl)methylidene]amino}acetic acid	details
4-hydroxy-1H-indole-3-carboxylic acid → 2-{[hydroxy(4-hydroxy-1H-indol-3-yl)methylidene]amino}acetic acid	details
Coumarin-4-carboxylic acid → 2-{[hydroxy(2-oxo-2H-chromen-4-yl)methylidene]amino}acetic acid	details
6-hydroxy-2-oxo-2H-chromene-4-carboxylic acid → 2-{[hydroxy(6-hydroxy-2-oxo-2H-chromen-4-yl)methylidene]amino}acetic acid	details
7-hydroxy-2-oxo-2H-chromene-4-carboxylic acid → 2-{[hydroxy(7-hydroxy-2-oxo-2H-chromen-4-yl)methylidene]amino}acetic acid	details
8-hydroxy-2-oxo-2H-chromene-4-carboxylic acid → 2-{[hydroxy(8-hydroxy-2-oxo-2H-chromen-4-yl)methylidene]amino}acetic acid	details
5-hydroxy-2-oxo-2H-chromene-4-carboxylic acid → 2-{[hydroxy(5-hydroxy-2-oxo-2H-chromen-4-yl)methylidene]amino}acetic acid	details
Theaflavic acid → 2-({hydroxy[3,4,6-trihydroxy-5-oxo-1-(3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-2-yl)-5H-benzo[7]annulen-8-yl]methylidene}amino)acetic acid	details
Epitheaflavic acid 3'-gallate → 2-[({1-[5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyloxy)-3,4-dihydro-2H-1-benzopyran-2-yl]-3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulen-8-yl}(hydroxy)methylidene)amino]acetic acid	details
5-hydroxy-2-{[1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxybenzoic acid → 2-{[hydroxy(5-hydroxy-2-{[1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxyphenyl)methylidene]amino}acetic acid	details
4,5-dihydroxy-2-{[1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-ylidene]amino}benzoic acid → 2-{[(4,5-dihydroxy-2-{[1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-ylidene]amino}phenyl)(hydroxy)methylidene]amino}acetic acid	details
2-{[3-(3,4-dihydroxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxy-4-methoxybenzoic acid → 2-{[(2-{[3-(3,4-dihydroxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxy-4-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
2-{[3-(2,4-dihydroxy-3-methoxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxy-4-methoxybenzoic acid → 2-{[(2-{[3-(2,4-dihydroxy-3-methoxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxy-4-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
2,3-dihydroxy-6-{[1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxybenzoic acid → 2-{[(2,3-dihydroxy-6-{[1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
2-{[3-(2,4-dihydroxy-5-methoxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxy-4-methoxybenzoic acid → 2-{[(2-{[3-(2,4-dihydroxy-5-methoxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxy-4-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
2-{[3-(3,4-dihydroxy-5-methoxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxy-4-methoxybenzoic acid → 2-{[(2-{[3-(3,4-dihydroxy-5-methoxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxy-4-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
5-hydroxy-2-({hydroxy[3-(4-hydroxy-3-methoxyphenyl)oxiran-2-yl]methylidene}amino)-4-methoxybenzoic acid → 2-({hydroxy[5-hydroxy-2-({hydroxy[3-(4-hydroxy-3-methoxyphenyl)oxiran-2-yl]methylidene}amino)-4-methoxyphenyl]methylidene}amino)acetic acid	details
5-hydroxy-2-{[1-hydroxy-3-(3-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxybenzoic acid → 2-{[hydroxy(5-hydroxy-2-{[1-hydroxy-3-(3-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxyphenyl)methylidene]amino}acetic acid	details
4,5-dihydroxy-2-{[1-hydroxy-3-(3-methoxyphenyl)prop-2-en-1-ylidene]amino}benzoic acid → 2-{[(4,5-dihydroxy-2-{[1-hydroxy-3-(3-methoxyphenyl)prop-2-en-1-ylidene]amino}phenyl)(hydroxy)methylidene]amino}acetic acid	details
5-hydroxy-2-{[1-hydroxy-3-(3-hydroxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxybenzoic acid → 2-{[hydroxy(5-hydroxy-2-{[1-hydroxy-3-(3-hydroxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxyphenyl)methylidene]amino}acetic acid	details
2,3-dihydroxy-6-{[1-hydroxy-3-(3-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxybenzoic acid → 2-{[(2,3-dihydroxy-6-{[1-hydroxy-3-(3-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
5-hydroxy-2-{[1-hydroxy-3-(3-hydroxy-5-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxybenzoic acid → 2-{[hydroxy(5-hydroxy-2-{[1-hydroxy-3-(3-hydroxy-5-methoxyphenyl)prop-2-en-1-ylidene]amino}-4-methoxyphenyl)methylidene]amino}acetic acid	details
5-hydroxy-2-({hydroxy[3-(3-methoxyphenyl)oxiran-2-yl]methylidene}amino)-4-methoxybenzoic acid → 2-({hydroxy[5-hydroxy-2-({hydroxy[3-(3-methoxyphenyl)oxiran-2-yl]methylidene}amino)-4-methoxyphenyl]methylidene}amino)acetic acid	details
2,4-Dihydroxybenzoic acid → 2-{[(2,4-dihydroxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
7,14-dihydroxy-6-methoxy-4,12-dimethyl-5-(3-methylbut-2-enoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[7,14-dihydroxy-6-methoxy-4,12-dimethyl-5-(3-methylbut-2-enoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
7,14-dihydroxy-6-methoxy-4,12-dimethyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[7,14-dihydroxy-6-methoxy-4,12-dimethyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
7,13,14-trihydroxy-6-methoxy-4,12-dimethyl-5-(3-methylbut-2-enoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({hydroxy[7,13,14-trihydroxy-6-methoxy-4,12-dimethyl-5-(3-methylbut-2-enoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl]methylidene}amino)acetic acid	details
7,13,14-trihydroxy-6-methoxy-4,12-dimethyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({hydroxy[7,13,14-trihydroxy-6-methoxy-4,12-dimethyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl]methylidene}amino)acetic acid	details
7,14-dihydroxy-4-(hydroxymethyl)-6-methoxy-12-methyl-5-(3-methylbut-2-enoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[7,14-dihydroxy-4-(hydroxymethyl)-6-methoxy-12-methyl-5-(3-methylbut-2-enoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
7,14-dihydroxy-4-(hydroxymethyl)-6-methoxy-12-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[7,14-dihydroxy-4-(hydroxymethyl)-6-methoxy-12-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbut-2-enoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbut-2-enoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
5-(3,3-dimethyloxirane-2-carbonyl)-7,14-dihydroxy-6-methoxy-4,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[5-(3,3-dimethyloxirane-2-carbonyl)-7,14-dihydroxy-6-methoxy-4,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
13-chloro-5,14-dihydroxy-7,12-dimethyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[13-chloro-5,14-dihydroxy-7,12-dimethyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
13-chloro-5,14-dihydroxy-12-(hydroxymethyl)-7-methyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[13-chloro-5,14-dihydroxy-12-(hydroxymethyl)-7-methyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
13-chloro-5,14-dihydroxy-7-(hydroxymethyl)-12-methyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[13-chloro-5,14-dihydroxy-7-(hydroxymethyl)-12-methyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
13-chloro-5,14-dihydroxy-6-(4-hydroxy-3-methylbut-2-en-1-yl)-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[13-chloro-5,14-dihydroxy-6-(4-hydroxy-3-methylbut-2-en-1-yl)-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
13-chloro-5,14-dihydroxy-6-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-[({13-chloro-5,14-dihydroxy-6-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl}(hydroxy)methylidene)amino]acetic acid	details
13-chloro-6-[(3,3-dimethyloxiran-2-yl)methyl]-5,14-dihydroxy-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-[({13-chloro-6-[(3,3-dimethyloxiran-2-yl)methyl]-5,14-dihydroxy-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl}(hydroxy)methylidene)amino]acetic acid	details
5,14-dihydroxy-7,12-dimethyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[5,14-dihydroxy-7,12-dimethyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
5,13,14-trihydroxy-7,12-dimethyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({hydroxy[5,13,14-trihydroxy-7,12-dimethyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl]methylidene}amino)acetic acid	details
5,14-dihydroxy-12-(hydroxymethyl)-7-methyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[5,14-dihydroxy-12-(hydroxymethyl)-7-methyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
5,14-dihydroxy-7-(hydroxymethyl)-12-methyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[5,14-dihydroxy-7-(hydroxymethyl)-12-methyl-6-(3-methylbut-2-en-1-yl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
6-[(3,3-dimethyloxiran-2-yl)methyl]-5,14-dihydroxy-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-[({6-[(3,3-dimethyloxiran-2-yl)methyl]-5,14-dihydroxy-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl}(hydroxy)methylidene)amino]acetic acid	details
5,14-dihydroxy-6-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-[({5,14-dihydroxy-6-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl}(hydroxy)methylidene)amino]acetic acid	details
5,14-dihydroxy-6-(4-hydroxy-3-methylbut-2-en-1-yl)-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid → 2-({[5,14-dihydroxy-6-(4-hydroxy-3-methylbut-2-en-1-yl)-7,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-15-yl](hydroxy)methylidene}amino)acetic acid	details
4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoic acid → 2-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]formamido}acetic acid	details
4-hydroxy-3-(4-hydroxy-3-methylbut-2-en-1-yl)benzoic acid → 2-{[4-hydroxy-3-(4-hydroxy-3-methylbut-2-en-1-yl)phenyl]formamido}acetic acid	details
3-[(3,3-dimethyloxiran-2-yl)methyl]-4-hydroxybenzoic acid → 2-[({3-[(3,3-dimethyloxiran-2-yl)methyl]-4-hydroxyphenyl}(hydroxy)methylidene)amino]acetic acid	details
3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)benzoic acid → 2-({[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl](hydroxy)methylidene}amino)acetic acid	details
Isovanillic acid → 2-{[hydroxy(3-hydroxy-4-methoxyphenyl)methylidene]amino}acetic acid	details
2,5-dihydroxy-4-methoxybenzoic acid → 2-{[(2,5-dihydroxy-4-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
2,3-dihydroxy-4-methoxybenzoic acid → 2-{[(2,3-dihydroxy-4-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
2,3,4-trimethoxybenzoic acid → 2-{[hydroxy(2,3,4-trimethoxyphenyl)methylidene]amino}acetic acid	details
3-hydroxy-2,4-dimethoxybenzoic acid → 2-{[hydroxy(3-hydroxy-2,4-dimethoxyphenyl)methylidene]amino}acetic acid	details
2-hydroxy-3,4-dimethoxybenzoic acid → 2-{[hydroxy(2-hydroxy-3,4-dimethoxyphenyl)methylidene]amino}acetic acid	details
4-hydroxy-2,3-dimethoxybenzoic acid → 2-{[hydroxy(4-hydroxy-2,3-dimethoxyphenyl)methylidene]amino}acetic acid	details
6-hydroxy-2,3,4-trimethoxybenzoic acid → 2-{[hydroxy(6-hydroxy-2,3,4-trimethoxyphenyl)methylidene]amino}acetic acid	details
2-Methoxybenzoic acid → 2-{[hydroxy(2-methoxyphenyl)methylidene]amino}acetic acid	details
2,4-dihydroxy-3-methoxybenzoic acid → 2-{[(2,4-dihydroxy-3-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details
2,4-dihydroxy-5-methoxybenzoic acid → 2-{[(2,4-dihydroxy-5-methoxyphenyl)(hydroxy)methylidene]amino}acetic acid	details

GO Classification

Biological Process
acyl-CoA metabolic process
glycine metabolic process
monocarboxylic acid metabolic process
xenobiotic metabolic process
response to toxin
Cellular Component
mitochondrial matrix
Component
mitochondrion
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
glycine n-acyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
acyltransferase activity
n-acyltransferase activity
Molecular Function
glycine N-acyltransferase activity
glycine N-benzoyltransferase activity

Cellular Location

Mitochondrion

Gene Properties

Chromosome Location

Locus

11q12.1

SNPs

GLYAT

Gene Sequence

>891 bp
ATGATGTTACCATTGCAAGGTGCCCAGATGCTGCAGATGCTGGAGAAATCCTTGAGGAAG
AGCCTCCCAGCATCCTTAAAGGTTTATGGAACTGTCTTTCACATAAACCATGGAAATCCA
TTCAATCTGAAGGCTGTGGTGGACAAGTGGCCTGATTTTAATACAGTGGTTGTCTGCCCT
CAGGAGCAGGATATGACAGATGACCTTGATCACTATACCAATACTTACCAAATCTACTCC
AAAGATCCCCAAAACTGTCAGGAATTCCTTGGATCACCAGAACTCATCAACTGGAAACAG
CATTTACAGATTCAAAGTTCACAGCCTAGCCTGAATGAGGCTATACAAAATCTTGCAGCC
ATTAAGTCCTTCAAAGTCAAACAAACACAACGCATTCTCTATATGGCAGCTGAAACAGCC
AAGGAACTGACTCCTTTCCTGCTGAAATCAAAGATTTTATCTCCCAATGGTGGCAAACCC
AAGGCCATCAACCAAGAGATGTTTAAACTCTCATCCATGGATGTTACCCATGCTCACTTG
GTGAATAAATTCTGGCATTTTGGTGGTAATGAGAGGAGCCAGAGATTCATTGAGCGCTGC
ATTCAGACCTTTCCCACCTGCTGTCTCCTGGGGCCTGAGGGGACCCCTGTGTGCTGGGAT
CTAATGGACCAGACTGGAGAGATGAGAATGGCAGGCACCTTGCCGGAATACCGGCTCCAT
GGCCTTGTGACGTATGTCATCTATTCCCACGCCCAGAAATTGGGCAAACTTGGGTTTCCT
GTCTATTCTCATGTAGACTACAGCAATGAAGCTATGCAAAAAATGAGTTACACACTGCAA
CATGTTCCCATTCCCAGAAGCTGGAACCAGTGGAACTGTGTACCTCTGTGA

Protein Properties

Number of Residues

296

Molecular Weight

18506.33

Theoretical pI

8.703

Pfam Domain Function

Gly_acyl_tr_C (PF08444 )
Gly_acyl_tr_N (PF06021 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Glycine N-acyltransferase
MMLPLQGAQMLQMLEKSLRKSLPASLKVYGTVFHINHGNPFNLKAVVDKWPDFNTVVVCP
QEQDMTDDLDHYTNTYQIYSKDPQNCQEFLGSPELINWKQHLQIQSSQPSLNEAIQNLAA
IKSFKVKQTQRILYMAAETAKELTPFLLKSKILSPSGGKPKAINQEMFKLSSMDVTHAHL
VNKFWHFGGNERSQRFIERCIQTFPTCCLLGPEGTPVCWDLMDQTGEMRMAGTLPEYRLH
GLVTYVIYSHAQKLGKLGFPVYSHVDYSNEAMQKMSYTLQHVPIPRSWNQWNCVPL

External Links

GenBank ID Protein

111038137

UniProtKB/Swiss-Prot ID

Q6IB77

UniProtKB/Swiss-Prot Entry Name

GLYAT_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [PubMed:16554811 ]
van der Westhuizen FH, Pretorius PJ, Erasmus E: The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase. J Biochem Mol Toxicol. 2000;14(2):102-9. [PubMed:10630424 ]
Mawal YR, Qureshi IA: Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver. Biochem Biophys Res Commun. 1994 Dec 15;205(2):1373-9. [PubMed:7802672 ]