Hmdb loader
Identification
HMDB Protein ID HMDBP03314
Secondary Accession Numbers
  • 8895
Name Enoyl-CoA delta isomerase 1, mitochondrial
Synonyms
  1. D3,D2-enoyl-CoA isomerase
  2. Delta(3),Delta(2)-enoyl-CoA isomerase
  3. Dodecenoyl-CoA isomerase
  4. 3,2-trans-enoyl-CoA isomerase
Gene Name ECI1
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.
Pathways
  • fatty acid beta-oxidation
  • fatty acid metabolism
Reactions
(3Z)-dodec-3-enoyl-CoA → (2E)-Dodecenoyl-CoA details
cis,cis-3,6-Dodecadienoyl-CoA → trans,cis-Lauro-2,6-dienoyl-CoA details
GO Classification
Biological Process
fatty acid beta-oxidation
Cellular Component
mitochondrial matrix
mitochondrial inner membrane
Function
catalytic activity
Molecular Function
dodecenoyl-CoA delta-isomerase activity
Process
metabolic process
Cellular Location
  1. Mitochondrion matrix
Gene Properties
Chromosome Location 16
Locus 16p13.3
SNPs DCI
Gene Sequence
>909 bp
ATGGCGCTGGTGGCTTCTGTGCGAGTCCCGGCGCGCGTTCTGCTCCGCGCGGGGGCCCGG
CTCCCGGGCGCGGCCCTCGGGCGGACGGAGCGGGCGGCCGGCGGCGGAGACGGCGCGCGG
CCGTTCGGGAGCCAGCGGGTGCTGGTGGAGCCGGACGCGGCCGCAGGGGTCGCTGTGATG
AAATTCAAGAACCCCCCAGTGAACAGCCTGAGCCTGGAGTTTCTGACGGAGCTGGTCATC
AGCCTGGAGAAGCTGGAGAATGACAAGAGCTTCCGCGGTGTCATTCTGACCTCGGACCGC
CCGGGTGTCTTCTCGGCCGGCCTGGACCTGACGGAGATGTGTGGGAGGAGCCCCGCCCAC
TACGCTGGGTACTGGAAGGCCGTTCAGGAGCTGTGGCTGCGGTTGTACCAGTCCAACCTG
GTGCTGGTCTCCGCCATCAACGGAGCCTGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACC
TGTGACTACCGCATCCTGGCGGACAACCCCAGGTACTGCATAGGACTCAATGAGACCCAG
CTGGGCATCATCGCCCCTTTCTGGTTGAAAGACACCCTGGAGAACACCATCGGGCACCGG
GCGGCGGAGCGTGCCCTGCAGCTGGGGCTGCTCTTCCCGCCGGCGGAGGCCCTGCAGGTG
GGCATAGTGGACCAGGTGGTCCCGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCGATA
GCCCAGTGGATGGCCATTCCAGACCATGCTCGACAGCTGACCAAGGCCATGATGCGAAAG
GCCACGGCCAGCCGCCTGGTCACGCAGCGCGATGCGGACGTGCAGAACTTCGTCAGCTTC
ATCTCCAAAGACTCCATCCAGAAGTCCCTGCAGATGTACTTAGAGAGGCTCAAAGAAGAA
AAAGGCTAA
Protein Properties
Number of Residues 302
Molecular Weight 30895.4
Theoretical pI 8.899
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>3,2-trans-enoyl-CoA isomerase, mitochondrial
MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARRFGSQRVLVEPDAGAGVAVM
KFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAH
YAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRYCIGLNETQ
LGIIAPFWLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAI
AQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEE
KG
GenBank ID Protein 472987
UniProtKB/Swiss-Prot ID P42126
UniProtKB/Swiss-Prot Entry Name D3D2_HUMAN
PDB IDs
GenBank Gene ID Z25820
GeneCard ID DCI
GenAtlas ID DCI
HGNC ID HGNC:2703
References
General References
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  3. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  4. Janssen U, Fink T, Lichter P, Stoffel W: Human mitochondrial 3,2-trans-enoyl-CoA isomerase (DCI): gene structure and localization to chromosome 16p13.3. Genomics. 1994 Sep 1;23(1):223-8. [PubMed:7829074 ]
  5. Kilponen JM, Hayrinen HM, Rehn M, Hiltunen JK: cDNA cloning and amino acid sequence of human mitochondrial delta 3 delta 2-enoyl-CoA isomerase: comparison of the human enzyme with its rat counterpart, mitochondrial short-chain isomerase. Biochem J. 1994 May 15;300 ( Pt 1):1-5. [PubMed:8198519 ]
  6. Takahashi Y, Hirata Y, Burstein Y, Listowsky I: Delta 3, delta 2-enoyl-CoA isomerase is the protein that copurifies with human glutathione S-transferases from S-hexylglutathione affinity matrices. Biochem J. 1994 Dec 15;304 ( Pt 3):849-52. [PubMed:7818490 ]
  7. Partanen ST, Novikov DK, Popov AN, Mursula AM, Hiltunen JK, Wierenga RK: The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group. J Mol Biol. 2004 Sep 24;342(4):1197-208. [PubMed:15351645 ]