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Showing Protein Superoxide dismutase [Cu-Zn] (HMDBP02053)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 9 metabolites
Identification
HMDB Protein ID HMDBP02053
Secondary Accession Numbers
  • 7532
Name Superoxide dismutase [Cu-Zn]
Synonyms
  1. Superoxide dismutase 1
  2. hSod1
Gene Name SOD1
Protein Type Unknown
Biological Properties
General Function Involved in metal ion binding
Specific Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Pathways
  • Amyotrophic lateral sclerosis
  • Degradation of Superoxides
  • Huntington disease
  • Peroxisome
  • Prion disease
Reactions
Superoxide + Hydrogen Ion → Oxygen + Hydrogen peroxide details
GO Classification
Biological Process
sensory perception of sound
locomotory behavior
spermatogenesis
apoptotic DNA fragmentation
embryo implantation
heart contraction
muscle cell homeostasis
positive regulation of apoptotic process
platelet activation
platelet degranulation
anterograde axon cargo transport
negative regulation of neuron apoptotic process
myeloid cell homeostasis
negative regulation of cholesterol biosynthetic process
response to heat
neurofilament cytoskeleton organization
peripheral nervous system myelin maintenance
regulation of organ growth
regulation of T cell differentiation in thymus
retina homeostasis
retrograde axon cargo transport
thymus development
regulation of mitochondrial membrane potential
double-strand break repair
positive regulation of cytokine production
response to drug
response to ethanol
hydrogen peroxide biosynthetic process
cellular iron ion homeostasis
glutathione metabolic process
response to amphetamine
regulation of multicellular organism growth
cell aging
auditory receptor cell stereocilium organization
relaxation of vascular smooth muscle
superoxide anion generation
regulation of blood pressure
response to nutrient levels
removal of superoxide radicals
placenta development
response to hydrogen peroxide
response to axon injury
response to copper ion
activation of MAPK activity
ovarian follicle development
Cellular Component
cytosol
mitochondrial matrix
nucleus
neuronal cell body
extracellular space
peroxisome
extracellular matrix
dendrite cytoplasm
cytoplasmic vesicle
protein complex
Function
ion binding
cation binding
metal ion binding
binding
Molecular Function
superoxide dismutase activity
zinc ion binding
protein homodimerization activity
copper ion binding
protein phosphatase 2B binding
Process
metabolic process
cellular metabolic process
oxidation reduction
oxygen and reactive oxygen species metabolic process
superoxide metabolic process
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location 21
Locus 21q22.11
SNPs SOD1
Gene Sequence 
>465 bp
ATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAAT
TTCGAGCAGAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACT
GAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGCTGTACCAGT
GCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGG
CATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATT
GAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTC
CATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAAC
GCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAA
Protein Properties
Number of Residues 154
Molecular Weight 15935.685
Theoretical pI 6.122
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Superoxide dismutase [Cu-Zn]
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
GenBank ID Protein 36542
UniProtKB/Swiss-Prot ID P00441
UniProtKB/Swiss-Prot Entry Name SODC_HUMAN
PDB IDs
GenBank Gene ID X02317
GeneCard ID SOD1
GenAtlas ID SOD1
HGNC ID HGNC:11179
References
General References
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